In 2020, roughly 7.4 million inhabitants aged three or older spoke an indigenous language in Mexico. In the case of Afro-descendants or Afro-Mexicans, a total of 2.6 million people defined themselves as such.

Indigenous families in Mexico Mexico is one of the countries with the largest share of indigenous language speakers in Latin America. The number of indigenous households stood at 2.9 million in 2020. This figure includes all family units where at least one member or their ancestors declared speaking an indigenous language. Native ethnicities in Mexico generally endure higher and more severe poverty levels. Indigenous people are also in a more vulnerable socio-economic situation. For instance, more than 30 percent of the indigenous population in Mexico lagged in education, almost double the share of non-indigenous population.

Mexico's Afro-descendants Thanks to its millennia-long indigenous ancestry, Mexico is a multiethnic country that amasses one of the richest cultural heritages in the world. During colonial times, millions of slaves from the African continent were brought to Mexican territory. Their contribution to today's Mexican identity is sometimes overlooked. In 2020, around one million households in the country had at least one member who self-perceived as an Afro-descendant, or had ancestors with this ethnicity. Guerrero and Oaxaca are nowadays the states with the largest share of Afro-Mexicans.

The statistic depicts the ten largest cities in Mexico in 2020. In 2020, Mexico City had around 8.84 million residents which made it the largest city in Mexico.

Population of Mexico

Mexico is a federal republic located in North America, sharing borders with the United States to the north, and to the southeast with Guatemala and Belize. With a total area of over 1.9 million square kilometers, it is the fourteenth largest nation in the world and the fifth largest in the Americas.

In 2014, Mexico’s total population amounted to approximately 120 million people. A little under two thirds of Mexico’s total population is of Mestizo ethnicity. The total population has steadily grown over the past decade, despite being the source to the largest migration flow between countries in the world; in 2010, around 11.6 million immigrants from Mexico lived in the United States. The migration flow between the United States and Mexico has however, decreased over the past ten years: Between 1995 and 2000, over 2.9 million migrants emigrated from Mexico to the United States. This was more than the double of migrants who emigrated from Mexico to the United States between 2005 and 2010. Each year, Mexico's population grows by about 1.24 percent compared to the previous year. Mexico City, the country’s capital and largest city, is home to approximately 8.6 million people.

All p-values were adjusted with the method of false discovery rates, those data presented in bold depicted significant values. ARA, Aragon; CAT, Cataluña; CHU, Chuetas; CLM, Castilla la Mancha; COR, Corsica; CVA, Comunitat Valenciana; CVMg, Central Valley of Mexico from Gomez et al.; CYL, Castilla y Leon; CANT, Cantabria; EXT, Extremadura; FRA, France; GTO, Guanajuato; ITA, Italy; JEWS-ASH, Ashkenazi Jews; JEWS-COHEN, Cohen Jews; JEWS-LEVI, Levite Jews; MAD, Madrid; MAJ, Majorca; MUR, Murcia; MAGH, Maghreb; NEA, Near East; NL, Nuevo Leon; NAFR, North Africa; MAJ, Majorca; PVA, Basque Country; RIO, La Rioja; SEPH-IBP; Sephardim Jews from the Iberian Peninsula; YEM, Yemen. (XLSX)

The statistic depicts the unemployment rate in Mexico from 1999 to 2023. In 2023, Mexico's unemployment rate was around 2.77 percent. Mexico's population Mexico is the third largest country in North America. Mexico’s economy has developed and improved over the years, partially due to a better relationship with the United States. Mexico’s total population was estimated to amount to around 120 million people in 2014, with the majority, i.e. more than 60 percent, having a Mestizo background. Despite a remarkably high migration flow between Mexico and the United States, with more than 11.5 million Mexican migrants living in the United States, Mexico’s population is still growing at a constant rate. In addition, life expectancy in Mexico is increasing, pointing towards an improvement of living conditions. However, the high total population numbers affect the population density. In 2012, there were more than 62 inhabitants per square kilometer registered, ten more than a decade ago. This trend is most likely to increase but not worriyngly so, since Mexico is still far from being one of the countries with the highest population density . Among the Mexican metropolises, Mexico City has the highest number of residents by far.

ID, identification of samples; NR, data not reported. (XLSX)

ID, identification of samples; NR, data not reported. (XLSX)

Helicobacter pylori strains carry a range of mutations in genes that confer antimicrobial resistance and restrict the available options to treat the infection. Latin America is a region that conserve a large number of indigenous communities relatively isolated that practice a traditional medicine without consumption of drugs. We hypothesized that rates of antibiotic resistance are lower in these communities. Recent progress in whole-genome sequencing has allowed the study of drug susceptibility by searching for the known mutations associated with antibiotic resistance. The aim of this work was to study trends of antibiotic resistance over a 20-year period in Mexican H. pylori strains and to compare susceptibility between strains from Mexican mestizos and from indigenous population; we also aimed to learn the prevalence of mutational patterns in genes gyrA, gyrB, rdxA, frxA, rpsU, omp11, dppA, and 23S rRNA and its association with phenotypic tests. Resistance to clarithromycin, metronidazole, amoxicillin and levofloxacin was determined in167 H. pylori isolates by E-test, and the occurrence of mutational patterns in specific genes was determined by whole genome sequencing (WGS). The trend of resistance over 20 years in mestizo isolates showed significant resistant increase for clarithromycin and levofloxacin to frequencies that banned its clinical use. Resistance in H. pylori isolates of native communities was lower for all antibiotics tested. Phenotypic resistance showed good to moderate correlation with genotypic tests. Genetic methods for characterizing antibiotic resistance require further validation in each population.