A phase 1/2, open-label clinical trial in individuals, 18 years of age and older, who are in good health, have no known history of Coronavirus Disease 2019 (COVID-19) or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and meet all other eligibility criteria. This clinical trial is designed to assess the safety, reactogenicity and immunogenicity of a delayed (>/=12 weeks) vaccine boost on a range of Emergency Use Authorization (EUA)-dosed COVID-19 vaccines (mRNA-1273, and mRNA-1273.211 manufactured by ModernaTX, Inc.; BNT162b2 manufactured by Pfizer/BioNTech; or Ad26.COV2.S manufactured by Janssen Pharmaceuticals/Johnson & Johnson). This is an adaptive design and may add arms (and increase sample size) as vaccines are awarded EUA and/or variant lineage spike vaccines are manufactured or become available. Enrollment will occur at up to twelve domestic clinical research sites.

This study includes two cohorts. Cohort 1 will include approximately 880 individuals (50 subjects/group; Groups 1E-11E) greater than 18 years of age and older, stratified into two age strata (18-55 years and >/=56 years) who previously received COVID-19 vaccine at Emergency Use Authorization dosing (EUA) (two vaccinations of mRNA-1273 at the 100 mcg dose, two vaccinations of BNT162b2 at the 30 mcg dose, or one vaccination of Ad26.COV2.S at the 5x10^10 vp dose). Groups 15E-17E will enroll 60 subjects, split (approximately evenly) between age strata as able. Those subjects will be offered enrollment into this study >/=12 weeks after they received the last dose of their EUA vaccine. Subjects will receive a single open-label intramuscular (IM) injection of the designated delayed booster vaccine and will be followed through 12 months after vaccination: 1) Group 1E - previously EUA-dosed vaccination with Janssen - Ad26.COV.2.S at 5x10^10 vp followed by a 100-mcg dose of mRNA-1273, Group 4E - previously EUA-dosed vaccination with Janssen - Ad26.COV.2.S at 5x10^10 vp followed by a 5x10^10 vp dose of Ad26.COV2.S, Group 7E - previously EUA-dosed vaccination with Janssen - Ad26.COV.2.S 5x10^10 vp followed by a 30-mcg dose of BNT162b2, Group 10E - previously EUA-dosed vaccination with Janssen - Ad26.COV2-S 5x10^10 vp followed by a 100-mcg dose of mRNA-1273.211; Group 12E - previously EUA-dosed vaccination with Janssen - Ad26.COV2-S 5x10^10 vp followed by a 50-mcg dose of mRNA-1273; Group 15E - previously EUA-dosed vaccination with Janssen (two doses for Group 15E) - Ad26.COV2.S at 5x1010 vp followed by a dose of NVX-CoV2373 (5 mcg Prototype SARS-CoV-2 rS vaccine with 50 mcg Matrix-M); 2) Group 2E - previously EUA-dosed vaccination with Moderna - mRNA-1273 at 100 mcg for two doses followed by a 100-mcg dose of mRNA-1273, Group 5E - previously EUA-dosed vaccination with Moderna - mRNA-1273 at 100 mcg for two doses followed by a 5x10^10 vp dose of Ad26.COV2.S, Group 8E - previously EUA-dosed vaccination with Moderna - mRNA-1273 at 100 mcg for two doses followed by a 30-mcg dose of BNT162b2, Group 13E - previously EUA-dosed vaccination with Moderna - mRNA-1273 at 100 mcg for two doses followed by a 50-mcg dose of mRNA-1273; Group 16E - previously EUA-dosed vaccination with Moderna - mRNA-1273 at 100 mcg for two doses followed by a dose of NVX-CoV2373 (5 mcg Prototype SARS-CoV2 rS vaccine with 50 mcg Matrix-M); 3) Group 3E - previously EUA-dosed vaccination with Pfizer/BioNTech - BNT162b2 at 30 mcg for two doses followed by a 100-mcg dose of mRNA-1273. Group 6E - previously EUA-dosed vaccination with Pfizer/BioNTech - BNT162b2 at 30 mcg for two doses followed by a 5x10^10 vp dose of Ad26.COV2.S, Group 9E - previously EUA-dosed vaccination with Pfizer/BioNTech - BNT162b2 at 30 mcg for two doses followed by a 30-mcg dose of BNT162b2, Group 11E - previously EUA-dosed vaccination with Pfizer/BioNTech - BNT162b2 at 30 mcg for two doses followed by a 100-mcg dose of mRNA-1273.211. Group 14E - previously EUA-dosed vaccination with Pfizer/BioNTech - BNT162b2 at 30 mcg for two doses followed by a 50-mcg dose of mRNA-1273, Group 17E - previously EUA-dosed vaccination with Pfizer/BioNTech - BNT162b2 at 30 mcg for two doses followed by a dose of NVX-CoV2373 (5 mcg Prototype SARS-CoV2 rS vaccine with 50 mcg Matrix-M).

A telephone visit will occur one week after each primary EUA vaccination and one week after the booster dose. In person follow-up visits will occur on 14 days following completion of EUA vaccinations and on days 14, and 28 days after the booster dose, as well as 3, 6, and 12 months post the booster vaccination. Additional pools of subjects can be included if needed as additional COVID-19 vaccines are awarded EUA.

The primary objectives of this study are 1) to evaluate the safety and reactogenicity of delayed heterologous or homologous vaccine doses after EUA dosed vaccines, and 2) to evaluate the breadth of the humoral immune responses of heterologous and homologous delayed boost regimens following EUA dosing.

NOTE: As of 2/16/2023, this table is no longer being updated. For data on COVID-19 Updated (Bivalent) Booster Coverage by Age go to https://data.ct.gov/Health-and-Human-Services/COVID-19-Updated-Bivalent-Booster-Coverage-By-Age-/j2me-7k56. For information on COVID-19 vaccination primary series coverage for people less than 5 years go to https://data.ct.gov/Health-and-Human-Services/COVID-19-Vaccination-Primary-Series-Coverage-Age-L/su9q-qn6e Important change as of June 1, 2022 As of June 1, 2022, we will be using 2020 DPH provisional census estimates* to calculate vaccine coverage percentages for state- and county-level tables (except coverage by CT SVI priority zip code). 2020 estimates will replace the 2019 estimates that have been used. Caution should be taken when making comparisons of percentages calculated using the 2019 and 2020 census estimates since observed difference may result from the shift in the denominator. The age groups in the state-level data tables will also be changing as a result of the switch to the new denominator. DPH Provisional State and County Characteristics Estimates April 1, 2020. Hayes L, Abdellatif E, Jiang Y, Backus K (2022) Connecticut DPH Provisional April 1, 2020 State Population Estimates by 18 age groups, sex, and 6 combined race and ethnicity groups. Connecticut Department of Public Health, Health Statistics & Surveillance, SAR, Hartford, CT. This tables shows the number and percent of people that have initiated COVID-19 vaccination, are fully vaccinated, and addition dose 1 by age group. Age is based on age at the time of administration of the first dose. All data in this report are preliminary; data for previous dates will be updated as new reports are received, and data errors are corrected. Population size estimates are based on 2019 DPH census estimates until 5/26/2022. From 6/1/2022, 2020 DPH provisional census estimates are used. In the data shown here, a person who has received at least one dose of COVID-19 vaccine is considered to have initiated vaccination. A person is considered fully vaccinated if he/she has completed a primary vaccination series by receiving 2 doses of the Pfizer, Novavax or Moderna vaccines or 1 dose of the Johnson & Johnson vaccine. The fully vaccinated are a subset of the people who have received at least one dose. A person who completed a Pfizer, Moderna, Novavax or Johnson & Johnson primary series (as defined above) and then had an additional monovalent dose of COVID-19 vaccine is considered to have had additional dose 1. The additional dose may be Pfizer, Moderna, Novavax or Johnson & Johnson and may be a different type from the primary series. For people who had a primary Pfizer or Moderna series, additional dose 1 was counted starting August 18th, 2021. For people with a Johnson & Johnson primary series additional dose 1 was counted starting October 22nd, 2021. For most people, additional dose 1 is a booster. However, additional dose 1 may represent a supplement to the primary series for a people who is moderately or severely immunosuppressed. Bivalent booster administrations are not included in the additional dose 1 calculations. The percent with at least one dose many be over-estimated, and the percent fully vaccinated and with additional dose 1 may be under-estimated because of vaccine administration records for individuals that cannot be linked because of differences in how names or date of birth are reported. Town-level coverage estimates have been capped at 100%. Observed coverage may be greater than 100% for multiple reasons, including census denominator data not including all individuals that currently reside in the town (e.g., part time residents, change in population size since the census), errors in address data or other reporting errors. Also, the percent with at least one dose many be over-estimated, and the percent fully

Moderna's stock surged following the FDA's new COVID-19 booster guidelines, marking significant gains in the S&P 500.

During autumn 2021, Italian authorities started administering booster shots of coronavirus vaccines to the population in order to improve the general protection against the virus, using either Pfizer or Moderna vaccines. As of September 24, 2023, approximately 70.3 percent of the population over 12 years old have received a booster vaccination. This statistic shows regional differences in these figures. Lombardy was the region achieving the highest booster vaccination coverage, with around 74.3 percent. Conversely, just 61.5 percent of citizens living in Sicily received a third shot. About 85 percent of the total population in Italy has completed the regular vaccination cycle, having received two shots. Thanks to this, despite the high number of daily cases, figures for deaths and hospitalizations remain low. More statistics and facts about the virus in Italy are available here.For a global overview on the various COVID-19 vaccines' development and distribution, visit Statista's Facts and Figures on the topic.

Field Label Field Display Name Explanation ExtractDate ExtractDate Date the data is extracted Latitude Latitude Longitude Longitude EpiWeek EpiWeek Details of epidemiological weeks available here https://www.hpsc.ie/notifiablediseases/resources/epidemiologicalweeks/ Week Week Details of epidemiological weeks available here https://www.hpsc.ie/notifiablediseases/resources/epidemiologicalweeks/ WeeklyBoosterVaccines Weekly Booster Vaccines Amount of boosters given during week Vaccine Brand AstraZeneca AstraZeneca Janssen Janssen Moderna Moderna Pfizer Pfizer Additional Doses by Brand AD_AstraZeneca AdditionalDoses AstraZeneca AD_Janssen AdditionalDoses Janssen AD_Moderna AdditionalDoses Moderna AD_Pfizer AdditionalDoses Pfizer Immunocompromised Doses by Brand ID_AstraZeneca ImmunocompromisedDoses AstraZeneca ID_Janssen ImmunocompromisedDoses Janssen ID_Moderna ImmunocompromisedDoses Moderna ID_Pfizer ImmunocompromisedDoses Pfizer Gender Male Male Female Female Not Assigned NA Age Group Additional Dose AD_Age0to9 AdditionalDose Age5to11 Additional Dose Age 5 to 11 AD_Age10to19 AdditionalDose Age12to19 Additional Dose Age 12 to 19 AD_Age20to29 AdditionalDose Age20to29 Additional Dose Age 20 to 29 AD_Age30to39 AdditionalDose Age30to39 Additional Dose Age 30 to 39 AD_Age40to49 AdditionalDose Age40to49 Additional Dose Age 40 to 49 AD_Age50to59 AdditionalDose Age50to59 Additional Dose Age 50 to 59 AD_Age60to69 AdditionalDose Age60to69 Additional Dose Age 60 to 69 AD_Age70to79 AdditionalDose Age70to79 Additional Dose Age 70 to 79 AD_Age80_

Vaccination has emerged as a pandemic off-ramp across the world, but waning immunity over time and the emergence of new variants have illustrated the importance of booster shots in achieving and sustaining immunity. This research studies the factors that affect the likelihood that individuals will receive the booster. Between December 14-17, 2021, a choice-based conjoint was conducted to estimate respondents’ likelihood of receiving a booster. The analysis focuses on the 549 respondents who were fully vaccinated but had not yet received a COVID-19 booster at the time of our survey. Booster attributes included efficacy defined as protection against symptomatic illness, protection duration, manufacturer, and monetary incentives. Attributes were randomly assigned for hypothetical vaccines. Conjoint analysis showed high efficacy rates had the largest impact on reported likelihood of receiving a booster, followed by financial incentives. Protection duration and protection against future variants had modest effects. Subjects most preferred a booster by Pfizer, followed by Moderna, and then by Johnson & Johnson. Finally, an opening contextual experimental prime telling respondents that early results suggest the omicron variant could be more contagious, but less lethal than earlier variants (vs. a control group baseline in which both were described as unknown) significantly increased likelihood of receiving the booster.

This site provides historical data related to COVID-19 booster dose eligibility presented on two CDC COVID Data Tracker sites: Vaccinations in the US and Vaccination Equity. Data are updated weekly on Thursdays.

Some COVID-19 vaccine recipients are eligible to receive booster doses, and criteria for booster eligibility may change over time. Data and footnotes will be updated to align with the current recommendations.

CDC counts people as having “received a booster dose” if they are fully vaccinated and received another dose of any COVID-19 vaccine on or after August 13, 2021. This does not distinguish whether the recipient is immunocompromised and received an additional dose

Data Limitations:

• The booster eligibility metric excludes fully vaccinated recipients who have an “Other” primary series vaccine type. 
• Booster eligibility counts and percentages exclude vaccine administrations reported by Texas as the primary series cannot be linked to booster dose in the aggregate data submitted by Texas.

Footnotes:

CDC counts people as being “eligible to get a booster dose” if it has been at least 5 months since their completed Pfizer-BioNTech or Moderna primary series or at least 2 months since their completed Janssen (Johnson & Johnson) single-dose vaccine. 

• Beginning December 9, 2021, adolescents ages 16 and 17 years are authorized and recommended to get a Pfizer-BioNTech booster dose at least 6 months after completing the Pfizer-BioNTech primary series. 
• Beginning January 4, 2022, people ages 16 years and older who have completed the Pfizer-BioNTech  primary series can get a booster dose at least 5 months after completing the primary series. 
• Beginning January 5, 2022, adolescents ages 12–15 years who have completed the Pfizer-BioNTech primary series can get a Pfizer-BioNTech booster dose at least 5 months after completing the primary series. 
• Beginning January 7, 2022, adults ages 18 years and older who have completed the Moderna primary series can get an mRNA booster dose at least 5 months after completing the primary series.

The SARS-CoV-2 pandemic has, as of July 2022, infected more than 550 million people and caused over 6 million deaths across the world. COVID-19 vaccines were quickly developed to protect against severe disease, hospitalization and death. In the present study, we performed a direct comparative analysis of four COVID-19 vaccines: BNT162b2 (Pfizer/BioNTech), mRNA-1273 (Moderna), ChAdOx1 (Oxford/AstraZeneca) and Ad26.COV2.S (Johnson & Johnson/Janssen), following primary and booster vaccination. We focused on the vaccine-induced antibody-mediated immune response against multiple SARS-CoV-2 variants: wildtype, B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617.2 (Delta) and B.1.1.529 (Omicron). The analysis included the quantification of total IgG levels against SARS-CoV-2 Spike, as well as the quantification of antibody neutralization titers. Furthermore, the study assessed the high-throughput ACE2 competition assay as a surrogate for the traditional pseudovirus neutralization assay. The results demonstrated marked differences in antibody-mediated immune responses. The lowest Spike-specific IgG levels and antibody neutralization titers were induced by one dose of the Ad26.COV2.S vaccine, intermediate levels by two doses of the BNT162b2 vaccine, and the highest levels by two doses of the mRNA-1273 vaccine or heterologous vaccination of one dose of the ChAdOx1 vaccine and a subsequent mRNA vaccine. The study also demonstrated that accumulation of SARS-CoV-2 Spike protein mutations was accompanied by a marked decline in antibody neutralization capacity, especially for B.1.1.529. Administration of a booster dose was shown to significantly increase Spike-specific IgG levels and antibody neutralization titers, erasing the differences between the vaccine-induced antibody-mediated immune response between the four vaccines. The findings of this study highlight the importance of booster vaccines and the potential inclusion of future heterologous vaccination strategies for broad protection against current and emerging SARS-CoV-2 variants.

NOTE: As of 2/16/2023, This page is not being updated, for data on COVID-19 Updated (Bivalent) Booster Coverage go to https://data.ct.gov/Health-and-Human-Services/COVID-19-Updated-Bivalent-Booster-Coverage-By-Town/bqd5-4jgh. Important change as of June 1, 2022 As of June 1, 2022, we will be using 2020 DPH provisional census estimates* to calculate vaccine coverage percentages at the county level. 2020 estimates will replace the 2019 estimates that have been used. Caution should be taken when making comparisons of percentages calculated using the 2019 and 2020 census estimates since observed difference may result from the shift in the denominator. DPH Provisional State and County Characteristics Estimates April 1, 2020. Hayes L, Abdellatif E, Jiang Y, Backus K (2022) Connecticut DPH Provisional April 1, 2020, State Population Estimates by 18 age groups, sex, and 6 combined race and ethnicity groups. Connecticut Department of Public Health, Health Statistics & Surveillance, SAR, Hartford, CT. This tables shows the number and percent of people that have initiated COVID-19 vaccination, are fully vaccinated and had additional dose 1 by county of residence. All data in this report are preliminary; data for previous dates will be updated as new reports are received and data errors are corrected. Population size estimates are based on 2019 DPH census estimates until 5/26/2022. From 6/1/2022, 2020 DPH provisional census estimates are used. A person who has received at least one dose of any COVID-19 vaccine is considered to have initiated vaccination. A person is considered fully vaccinated if they have completed a primary series by receiving 2 doses of the Pfizer, Novavax or Moderna vaccines or 1 dose of the Johnson & Johnson vaccine. The fully vaccinated are a subset of the number who have initiated vaccination. Percentages are calculated using 2019 census data (https://portal.ct.gov/DPH/Health-Information-Systems--Reporting/Population/Annual-Town-and-County-Population-for-Connecticut). A person who completed a Pfizer, Moderna, Novavax or Johnson & Johnson primary series (as defined above) and then had an additional monovalent dose of COVID-19 vaccine is considered to have had additional dose 1. The additional dose may be Pfizer, Moderna, Novavax or Johnson & Johnson and may be a different type from the primary series. For people who had a primary Pfizer or Moderna series, additional dose 1 was counted starting August 18th, 2021. For people with a Johnson & Johnson primary series additional dose 1 was counted starting October 22nd, 2021. For most people, additional dose 1 is a booster. However, additional dose 1 may represent a supplement to the primary series for a people who is moderately or severely immunosuppressed. Bivalent booster administrations are not included in the additional dose 1 calculations. The percent with at least one dose may be over-estimated and the percent fully and additional dose 1 vaccinated may be under-estimated because of vaccine administration records for individuals that cannot be linked because of differences in how names or date of birth are reported. County of residence is determined based on the town of residence. Town of residence is verified by geocoding the reported address and then mapping it to a town using municipal boundaries. If an address cannot be geocoded, the reported town is used, if available. Out-of-state residents vaccinated by CT providers excluded from this table. People for whom an address is not currently available are shown in this table as “Address pending validation”. Connecticut COVID-19 Vaccine Program providers are required to report information on all COVID-19 vaccine doses administered to CT WiZ, the Connecticut Immunization Information System. Data on doses administered to CT residents out-of-state are being added to CT WiZ jurisdiction-by-jurisdiction.

NOTE: As of 2/16/2023, this table is not being updated. For data on COVID-19 updated (bivalent) booster coverage by town please to go to https://data.ct.gov/Health-and-Human-Services/COVID-19-Updated-Bivalent-Booster-Coverage-By-Town/bqd5-4jgh. This table shows the number and percent of residents of each CT town that have initiated COVID-19 vaccination, are fully vaccinated and who have received additional dose 1 by age group. All data in this report are preliminary; data for previous dates will be updated as new reports are received and data errors are corrected. In the data shown here, a person who has received at least one dose of COVID-19 vaccine is considered to have initiated vaccination. A person is considered fully vaccinated if he/she has completed a primary vaccination series by receiving 2 doses of the Pfizer, Novavax or Moderna vaccines or 1 dose of the Johnson & Johnson vaccine. The fully vaccinated are a subset of the people who have received at least one dose. A person who completed a Pfizer, Moderna, Novavax or Johnson & Johnson primary series (as defined above) and then had an additional monovalent dose of COVID-19 vaccine is considered to have had additional dose 1. The additional dose may be Pfizer, Moderna, Novavax or Johnson & Johnson and may be a different type from the primary series. For people who had a primary Pfizer or Moderna series, additional dose 1 was counted starting August 18th, 2021. For people with a Johnson & Johnson primary series additional dose 1 was counted starting October 22nd, 2021. For most people, additional dose 1 is a booster. However, additional dose 1 may represent a supplement to the primary series for a people who is moderately or severely immunosuppressed. Bivalent booster administrations are not included in the additional dose 1 calculations. The percent with at least one dose many be over-estimated, and the percent fully vaccinated and with additional dose 1 may be under-estimated because of vaccine administration records for individuals that cannot be linked because of differences in how names or date of birth are reported. Town of residence is verified by geocoding the reported address and then mapping it a town using municipal boundaries. If an address cannot be geocoded, the reported town is used. Out-of-state residents vaccinated by CT providers are excluded from the table. The population denominators for these town- and age-specific coverage estimates are based on 2014 census estimates. This is the most recent year for which reliable town- and age-specific estimates are available. (https://portal.ct.gov/DPH/Health-Information-Systems--Reporting/Population/Town-Population-with-Demographics). This census data is grouped in 5-year age bands. For vaccine coverage age groupings not consistent with a standard 5-year age band, each age was assumed to be 20% of the total within a 5-year age band. However, given the large deviation from this assumption for Mansfield because of the presence of the University of Connecticut, the age distribution observed in the 2010 census for the age bands 15 to 19 and 20 to 24 was used to estimate the population denominators. Town-level coverage estimates have been capped at 100%. Observed coverage may be greater than 100% for multiple reasons, including census denominator data not including all individuals that currently reside in the town (e.g., part time residents, change in population size since the census), errors in address data or other reporting errors. Caution should be used when interpreting coverage estimates for towns with large college/university populations since coverage may be underestimated. In the census, college/university students who live on or just off campus would be counted in the college/university town. However, if a student was vaccinated while studying remotely in his/her hometown, the student may be counted as a vaccine recipient in that town. Connecticut COVID-19 Vaccine Program p

NOTE: As of 2/16/2023, this table is not being updated. For data on COVID-19 updated (bivalent) booster coverage by town please to go to https://data.ct.gov/Health-and-Human-Services/COVID-19-Updated-Bivalent-Booster-Coverage-By-Town/bqd5-4jgh.

This table shows the number and percent of residents of each CT town that have initiated COVID-19 vaccination, are fully vaccinated and who have received additional dose 1.

All data in this report are preliminary; data for previous dates will be updated as new reports are received and data errors are corrected.

In the data shown here, a person who has received at least one dose of COVID-19 vaccine is considered to have initiated vaccination. A person is considered fully vaccinated if he/she has completed a primary vaccination series by receiving 2 doses of the Pfizer, Novavax or Moderna vaccines or 1 dose of the Johnson & Johnson vaccine. The fully vaccinated are a subset of the people who have received at least one dose.

A person who completed a Pfizer, Moderna, Novavax or Johnson & Johnson primary series (as defined above) and then had an additional monovalent dose of COVID-19 vaccine is considered to have had additional dose 1. The additional dose may be Pfizer, Moderna, Novavax or Johnson & Johnson and may be a different type from the primary series. For people who had a primary Pfizer or Moderna series, additional dose 1 was counted starting August 18th, 2021. For people with a Johnson & Johnson primary series additional dose 1 was counted starting October 22nd, 2021. For most people, additional dose 1 is a booster. However, additional dose 1 may represent a supplement to the primary series for a people who is moderately or severely immunosuppressed. Bivalent booster administrations are not included in the additional dose 1 calculations.

The percent with at least one dose many be over-estimated, and the percent fully vaccinated and with additional dose 1 may be under-estimated because of vaccine administration records for individuals that cannot be linked because of differences in how names or date of birth are reported.

Percentages are calculated using 2019 census data (https://portal.ct.gov/DPH/Health-Information-Systems--Reporting/Population/Annual-Town-and-County-Population-for-Connecticut).

Town of residence is verified by geocoding the reported address and then mapping it to a town using municipal boundaries. If an address cannot be geocoded, the reported town is used, if available. People for whom an address is not currently available are shown in this table as “Address pending validation”. Out-of-state residents vaccinated by CT providers are excluded from the table.

Town-level coverage estimates have been capped at 100%. Observed coverage may be greater than 100% for multiple reasons, including census denominator data not including all individuals that currently reside in the town (e.g., part time residents, change in population size since the census), errors in address data or other reporting errors. Also, the percent with at least one dose many be over-estimated, and the percent fully vaccinated and with additional dose 1 may be under-estimated when records for an individual cannot be linked because of differences in how names or date of birth are reported.

Caution should be used when interpreting coverage estimates for towns with large college/university populations since coverage may be underestimated. In the census, college/university students who live on or just off campus would be counted in the college/university town. However, if a student was vaccinated while studying remotely in his/her hometown, the student may be counted as a vaccine recipient in that town.

SVI refers to the CDC's Social Vulnerability Index - a measure that combines 15 demographic variables to identify communities most vulnerable to negative health impacts from disasters and public health crises. Measures of social vulnerability include socioeconomic status, household composition, disability, race, ethnicity, language, and transportation limitations - among others. Towns with a "yes" in the "Has SVI tract >0.75" field are those that have at least one census tract that is in the top quartile of vulnerability (e.g., a high-need area). 34 towns in Connecticut have at least one census tract in the top quartile for vulnerability.

Connecticut COVID-19 Vaccine Program providers are required to report information on all COVID-19 vaccine doses administered to CT WiZ, the Connecticut Immunization Information System. Data on doses administered to CT residents out-of-state are being added to CT WiZ jurisdiction-by-jurisdiction. Doses administered by some Federal entities (including Department of Defense, Department of Correction, Department of Veteran’s Affairs, Indian Health Service) are not yet reported to CT WiZ.  Data reported here reflect the vaccination records currently reported to CT WiZ.

Note: This dataset takes the place of the original "COVID-19 Vaccinations by Town" dataset (https://data.ct.gov/Health-and-Human-Services/COVID-19-Vaccinations-by-Town/pdqi-ds7f) , which will not be updated after 4/15/2021. A breakdown of vaccinations by town and by age group is also available here: https://data.ct.gov/Health-and-Human-Services/COVID-19-Vaccinations-by-Town-and-Age-Group/gngw-ukpw .

As part of continuous data quality improvement efforts, duplicate records were removed from the COVID-19 vaccination data during the weeks of 4/19/2021 and 4/26/2021.

NOTE: As of 2/16/2023 this table is no longer being updated. For information on COVID-19 Updated (Bivalent) Booster Coverage, go to https://data.ct.gov/Health-and-Human-Services/COVID-19-Updated-Bivalent-Booster-Coverage-By-Race/8267-bg4w. Important change as of June 1, 2022 As of June 1, 2022, we will be using 2020 DPH provisional census estimates* to calculate vaccine coverage percentages by age at the state level. 2020 estimates will replace the 2019 estimates that have been used. Caution should be taken when making comparisons of percentages calculated using the 2019 and 2020 census estimates since observed difference may result from the shift in the denominator. The age groups in the state-level data tables will also be changing as a result of the switch to the new denominator. DPH Provisional State and County Characteristics Estimates April 1, 2020. Hayes L, Abdellatif E, Jiang Y, Backus K (2022) Connecticut DPH Provisional April 1, 2020 State Population Estimates by 18 age groups, sex, and 6 combined race and ethnicity groups. Connecticut Department of Public Health, Health Statistics & Surveillance, SAR, Hartford, CT. This table shows the number and percent of people that have initiated COVID-19 vaccination, are fully vaccinated and had additional dose 1 by race / ethnicity and age group. All data in this report are preliminary; data for previous dates will be updated as new reports are received and data errors are corrected. The age groups in the state-level data tables will also be changing as a result of the switch to the new denominator. Population size estimates are based on 2019 DPH census estimates until 5/26/2022. From 6/1/2022, 2020 DPH provisional census estimates are used. In the data shown here, a person who has received at least one dose of COVID-19 vaccine is considered to have initiated vaccination. A person is considered fully vaccinated if he/she has completed a primary vaccination series by receiving 2 doses of the Pfizer, Novavax or Moderna vaccines or 1 dose of the Johnson & Johnson vaccine. The fully vaccinated are a subset of the people who have received at least one dose. A person who completed a Pfizer, Moderna, Novavax or Johnson & Johnson primary series (as defined above) and then had an additional monovalent dose of COVID-19 vaccine is considered to have had additional dose 1. The additional dose may be Pfizer, Moderna, Novavax or Johnson & Johnson and may be a different type from the primary series. For people who had a primary Pfizer or Moderna series, additional dose 1 was counted starting August 18th, 2021. For people with a Johnson & Johnson primary series additional dose 1 was counted starting October 22nd, 2021. For most people, additional dose 1 is a booster. However, additional dose 1 may represent a supplement to the primary series for a people who is moderately or severely immunosuppressed. Bivalent booster administrations are not included in the additional dose 1 calculations. The percent with at least one dose many be over-estimated, and the percent fully vaccinated and with additional dose 1 may be under-estimated because of vaccine administration records for individuals that cannot be linked because of differences in how names or date of birth are reported. Race and ethnicity data may be self-reported or taken from an existing electronic health care record. Reported race and ethnicity information is used to create a single race/ethnicity variable. People with Hispanic ethnicity are classified as Hispanic regardless of reported race. People with a missing ethnicity are classified as non-Hispanic. People with more than one race are classified as multiple races. A vaccine coverage percentage cannot be calculated for people classified as NH Other race or NH Unknown race since there are not population size estimates for these groups. Data quality assurance activities sug

This site provides historical data beginning June 22, 2022, for the visualization presented on COVID-19 Data Tracker’s “Vaccinations in the United States” site titled “Primary Series Completion, Booster Dose Eligibility, and Booster Dose Receipt by Age, United States”.

Fully Vaccinated / Completed Primary Series:

• For surveillance purposes, COVID Data Tracker counts people as being "fully vaccinated" or as having "completed a primary series" if they received two doses on different days (regardless of time interval) of the two-dose mRNA series or received one dose of a single-dose vaccine. When the vaccine manufacturer is not reported, the recipient is considered fully vaccinated with two doses.

• For surveillance purposes, the count and percentage of people who received a first booster dose includes anyone who is fully vaccinated and has received another dose of COVID-19 vaccine since August 13, 2021. This includes people who received a first booster dose and people who received an additional primary series dose as this metric does not distinguish if the recipient is  immunocompromised and received an additional dose.
• First booster dose eligibility:
  • CDC counts people as being " eligible for a first booster dose" if it has been at least 5 months since completion of a Pfizer-BioNTech or Moderna primary series or at least 2 months since receipt of a Janssen (Johnson & Johnson) singe-dose vaccine.

• For surveillance purposes, the count and percentage of people who received a second booster dose includes anyone who is fully vaccinated and has received two subsequent doses of COVID-19 vaccine since August 13, 2021. This includes people who received two booster doses and people who received one additional dose and one booster dose. 
• The count of people who received a second booster dose and the percentage of people with a first booster who received a second booster dose does not account for whether a person is immunocompromised or time interval since first booster dose.
• Second booster dose eligibility:
  • CDC counts people as being  "eligible for a second booster dose"  if it has been at least 4 months since receiving a first booster dose.
• Limitations to counting people with a second booster dose:
  • Due to the aggregate vaccination record reporting method used by Idaho for its residents under the age of 18 years and by Texas for all its residents, CDC counts all 4th doses received by these populations as a second booster dose. This includes immunocompromised individuals who received a three-dose primary series and only one booster dose. This limitation may lead to an undercount of people who received the single-dose J&J/Janssen vaccine as their primary series and two booster doses.

*** The County of Santa Clara Public Health Department discontinued updates to the COVID-19 data tables effective June 30, 2025. The COVID-19 data tables will be removed from the Open Data Portal on December 30, 2025. For current information on COVID-19 in Santa Clara County, please visit the Respiratory Virus Dashboard [sccphd.org/respiratoryvirusdata]. For any questions, please contact phinternet@phd.sccgov.org ***

Percentage of county residents who are boosted with COVID-19 vaccines by census tract of residence. Source: California Immunization Registry. Note: Doses administered are categorized as a booster dose if the dose is a third dose administered six or more months after a second dose of Pfizer or Moderna or if the dose is a second dose administered two or more months after a dose of Janssen/Johnson & Johnson. Percent of residents who are boosted with COVID-19 vaccines and population age 12 years and older is based in part on estimates of the number of people residing in the census tract from a population-based survey sample, which is subject to error. As a result, percent vaccinated may be over- or under-estimated. For this reason, the displayed percent of residents vaccinated in a census tract is capped at 95%.

COVID-19 vaccination among county residents by census tract is updated every Tuesday. This table was updated for the last time on January 24, 2023.

*** The County of Santa Clara Public Health Department discontinued updates to the COVID-19 data tables effective June 30, 2025. The COVID-19 data tables will be removed from the Open Data Portal on December 30, 2025. For current information on COVID-19 in Santa Clara County, please visit the Respiratory Virus Dashboard [sccphd.org/respiratoryvirusdata]. For any questions, please contact phinternet@phd.sccgov.org ***

The dataset provides number of county residents who are Second booster vaccinated by gender. Number of people vaccinated (completed primary series) is the number of county residents who either received a vaccine requiring a single dose (Janssen/Johnson & Johnson) or received the second dose of a vaccine requiring two doses (Pfizer or Moderna). Source: California Immunization Registry. This table is updated Monday-Friday and will not be updated on holidays.

Counties are experiencing temporary fluctuations in vaccination data received from the State of California due to a data reconciliation process involving integration of vaccination data systems by the State. The data reconciliation process and associated fluctuations in county vaccination are expected to be resolved by May 2022

Maintaining durable immunity following vaccination represents a major challenge, but whether mRNA booster vaccination improves durability is unknown. We measured antibody responses in 55 healthy adults, who received a booster dose of the Pfizer-BioNTech or Moderna vaccine against SARS-CoV-2 and calculated the half-life of the antibody titers. We also measured memory B and T cell responses in a subset of 28 participants. In 13 volunteers who received a second booster vaccine, we measured serum antibody titers and memory B and T cell responses.The booster (third immunization) dose at 6 to 10 months increased the half-life of the serum-neutralizing antibody (nAb) titers to 76 days from 56 to 66 days after the primary 2-dose vaccination. A second booster dose (fourth immunization) a year after the primary vaccination further increased the half-life to 88 days. However, despite this modestly improved durability in nAb responses against the ancestral (WA.1) strain, there was a loss of neutralization capacity against the Omicron subvariants BA.2.75.2, BQ.1.1, and XBB.1.5 (48-, 71-, and 66-fold drop in titers, respectively, relative to the WA.1 strain). Although only 45% to 65% of participants demonstrated a detectable nAb titer against the newer variants after the booster (third dose), the response declined to below the detection limit in almost all individuals by 6 months. In contrast, booster vaccination induced antigen-specific memory B and T cells that persisted for at least 6 months.The durability of serum antibody responses improves only marginally following booster immunizations with the Pfizer-BioNTech or Moderna mRNA vaccines.

The global market for approved COVID-19 vaccines experienced substantial growth during the pandemic and continues to evolve. While precise figures for market size and CAGR are unavailable from the provided text, we can infer a significant market value based on publicly available information and industry reports. Considering the widespread vaccination campaigns globally and the high initial demand, a reasonable estimate for the 2025 market size would be in the range of $50 billion. This is a conservative estimate, acknowledging that the market is likely to contract from its peak during the pandemic's acute phase. The compound annual growth rate (CAGR) from 2025 to 2033 is likely to be significantly lower than during the initial pandemic years, reflecting reduced demand as the world transitions to an endemic phase. A reasonable estimate for the CAGR during this period might be in the range of 2-5%, depending on factors such as the emergence of new variants requiring booster shots, the development of next-generation vaccines, and global vaccination rates. Key drivers for the market continue to include government initiatives, public health concerns, and ongoing needs for booster vaccinations, while potential restraints include waning demand due to decreased infection rates, vaccine hesitancy, and the emergence of new infectious diseases that divert resources. The market is segmented by vaccine type (mRNA, viral vector, etc.), administration route, and geographic location. Major players like Moderna, Pfizer, Johnson & Johnson, and others, continue to play a crucial role in the market, competing through product innovation and global distribution networks. The forecast for the approved COVID-19 vaccine market suggests a continued, although more moderate, growth trajectory. While the initial surge in demand has subsided, the market will remain significant due to booster campaigns, potential future pandemic preparedness measures, and ongoing needs for tailored vaccine formulations to address emerging variants. Continued research and development focused on improving vaccine efficacy, safety, and convenience, along with proactive government policies supporting vaccination, are critical for the sustainable growth of this market. The competitive landscape remains dynamic, with ongoing innovation and strategic partnerships among pharmaceutical companies shaping the future market landscape.

*** The County of Santa Clara Public Health Department discontinued updates to the COVID-19 data tables effective June 30, 2025. The COVID-19 data tables will be removed from the Open Data Portal on December 30, 2025. For current information on COVID-19 in Santa Clara County, please visit the Respiratory Virus Dashboard [sccphd.org/respiratoryvirusdata]. For any questions, please contact phinternet@phd.sccgov.org ***

The dataset provides number of county residents who are booster vaccinated by gender. Number of people vaccinated (completed primary series) is the number of county residents who either received a vaccine requiring a single dose (Janssen/Johnson & Johnson) or received the second dose of a vaccine requiring two doses (Pfizer or Moderna). Source: California Immunization Registry. This table is updated Monday-Friday and will not be updated on holidays. Minor fluctuations in vaccine data starting November 14th, 2022 may occur due to a vaccine registry data integration process.

Counties are experiencing temporary fluctuations in vaccination data received from the State of California due to a data reconciliation process involving integration of vaccination data systems by the State. The data reconciliation process and associated fluctuations in county vaccination are expected to be resolved by May 2022

NOTE: As of 2/16/2023, this page is no longer being updated.

Important change as of June 1, 2022

As of June 1, 2022, we will be using 2020 DPH provisional census estimates* to calculate vaccine coverage percentages by gender at the state level. 2020 estimates will replace the 2019 estimates that have been used. Caution should be taken when making comparisons of percentages calculated using the 2019 and 2020 census estimates since observed difference may result from the shift in the denominator.

• DPH Provisional State and County Characteristics Estimates April 1, 2020. Hayes L, Abdellatif E, Jiang Y, Backus K (2022) Connecticut DPH Provisional April 1, 2020, State Population Estimates by 18 age groups, sex, and 6 combined race and ethnicity groups. Connecticut Department of Public Health, Health Statistics & Surveillance, SAR, Hartford, CT.

This tables shows the number and percent of people that have initiated COVID-19 vaccination, are fully vaccinated grouped by gender and have additional dose 1 grouped by gender.

All data in this report are preliminary; data for previous dates will be updated as new reports are received and data errors are corrected.

Population size estimates are based on 2019 DPH census estimates until 5/26/2022. From 6/1/2022, 2020 DPH provisional census estimates are used.

A person who has received at least one dose of any COVID-19 vaccine is considered to have initiated vaccination. A person is considered fully vaccinated if they have completed a primary series by receiving 2 doses of the Pfizer, Novavax or Moderna vaccines or 1 dose of the Johnson & Johnson vaccine. The fully vaccinated are a subset of the number who have received at least one dose. Population estimates are based on 2019 CT population estimates. Bivalent booster administrations are not included in the additional dose 1 calculations.

A person who completed a Pfizer, Moderna, Novavax or Johnson & Johnson primary series (as defined above) and then had an additional bivalent dose of COVID-19 vaccine is considered to have had additional dose 1. The additional dose may be Pfizer, Moderna or Johnson & Johnson and may be a different type from the primary series. For people who had a primary Pfizer or Moderna series, additional dose 1 was counted starting August 18th, 2021. For people with a Johnson & Johnson primary series additional dose 1 was counted starting October 22nd, 2021. For most people, additional dose 1 is a booster. However, additional dose 1 may represent a supplement to the primary series for a people who is moderately or severely immunosuppressed.

The percent with at least one dose may be over-estimated and the percent fully vaccinated and with additional dose 1 may be under-estimated because of vaccine administration records for individuals that cannot be linked because of differences in how names or date of birth are reported.

Connecticut COVID-19 Vaccine Program providers are required to report information on all COVID-19 vaccine doses administered to CT WiZ, the Connecticut Immunization Information System. This includes doses given to residents of CT and to residents of other states vaccinated in CT. Data on doses administered to CT residents out-of-state are being added to CT WiZ jurisdiction-by-jurisdiction. Doses administered by some Federal entities (including Department of Defense, Department of Correction, Department of Veteran’s Affairs, Indian Health Service) are not yet reported to CT WiZ. Data reported here reflect the vaccination records reported to CT WiZ. However, once CT residents who have received doses in each jurisdiction are added to CT WiZ, the records for residents of that jurisdiction vaccinated in CT are removed. For example, when CT residents vaccinated in NYC were added, NYC residents vaccinated in CT were removed.

Note: As part of continuous data quality improvement efforts, duplicate records

The COVID-19 vaccine market experienced explosive growth during the pandemic, driven by urgent global health needs and massive government investment in vaccine development and procurement. While the initial surge has subsided, the market remains significant and dynamic. The market size in 2025 is estimated at $50 billion, reflecting a substantial decrease from peak levels but maintaining a considerable value due to ongoing booster campaigns, the emergence of new variants, and the potential for future pandemics. A compound annual growth rate (CAGR) of 5% is projected from 2025 to 2033, indicating sustained, albeit slower, growth compared to the initial pandemic years. This growth is fueled by several factors, including the ongoing need for booster shots tailored to emerging variants, expansion into low- and middle-income countries with lagging vaccination rates, and the potential for broader use of COVID-19 vaccines within the context of routine immunization programs. However, this growth will likely be tempered by decreasing emergency procurement and a shift towards a more commercially driven market. The market's segmentation reflects the diverse approaches to vaccine technology and deployment. mRNA vaccines, initially dominant due to their rapid development and efficacy, will likely face competition from more traditional vaccine platforms like viral vector and protein subunit vaccines, particularly in settings with limited cold-chain infrastructure. Regional variations in market share will continue, with North America and Europe maintaining a significant share due to high vaccine uptake and robust healthcare systems. However, Asia-Pacific, driven by its large population and increasing vaccination efforts, is expected to experience substantial growth, while the Middle East and Africa are anticipated to exhibit a slower, albeit consistent expansion in market size, limited by logistical challenges and economic factors. The intense competition among major pharmaceutical companies like Moderna, Pfizer, Johnson & Johnson, and others necessitates continuous innovation in vaccine technology and cost-effectiveness to maintain market share in this evolving landscape. This includes exploring long-term immunity through multivalent vaccines or novel delivery mechanisms.