In the United States in 2021, the death rate was highest among those aged 85 and over, with about 17,190.5 men and 14,914.5 women per 100,000 of the population passing away. For all ages, the death rate was at 1,118.2 per 100,000 of the population for males, and 970.8 per 100,000 of the population for women. The death rate Death rates generally are counted as the number of deaths per 1,000 or 100,000 of the population and include both deaths of natural and unnatural causes. The death rate in the United States had pretty much held steady since 1990 until it started to increase over the last decade, with the highest death rates recorded in recent years. While the birth rate in the United States has been decreasing, it is still currently higher than the death rate. Causes of death There are a myriad number of causes of death in the United States, but the most recent data shows the top three leading causes of death to be heart disease, cancers, and accidents. Heart disease was also the leading cause of death worldwide.

Rank, number of deaths, percentage of deaths, and age-specific mortality rates for the leading causes of death, by age group and sex, 2000 to most recent year.

In 2022, the most significant cause of death among men in the United States was heart disease, which contributed to **** percent of deaths. COVID-19 was the third leading cause of death among U.S. men in both 2020 and 2021, and the fourth leading cause in 2022. This statistic shows the distribution of the ** leading causes of death among men in the United States from 2020 to 2022.

As of 2022, the third leading cause of death among teenagers aged 15 to 19 years in the United States was intentional self-harm or suicide, contributing around 17 percent of deaths among age group. The leading cause of death at that time was unintentional injuries, contributing to around 37.4 percent of deaths, while 21.8 percent of all deaths in this age group were due to assault or homicide. Cancer and heart disease, the overall leading causes of death in the United States, are also among the leading causes of death among U.S. teenagers. Adolescent suicide in the United States In 2021, around 22 percent of students in grades 9 to 12 reported that they had seriously considered attempting suicide in the past year. Female students were around twice as likely to report seriously considering suicide compared to male students. In 2022, Montana had the highest rate of suicides among U.S. teenagers with around 39 deaths per 100,000 teenagers, followed by South Dakota with a rate of 33 per 100,000. The states with the lowest death rates among adolescents are New York and New Jersey. Mental health treatment Suicidal thoughts are a clear symptom of mental health issues. Mental health issues are not rare among children and adolescents, and treatment for such issues has become increasingly accepted and accessible. In 2021, around 15 percent of boys and girls aged 5 to 17 years had received some form of mental health treatment in the past year. At that time, around 35 percent of youths aged 12 to 17 years in the United States who were receiving specialty mental health services were doing so because they had thought about killing themselves or had already tried to kill themselves.

Annual data on death registrations by single year of age for the UK (1974 onwards) and England and Wales (1963 onwards).

Number of deaths and mortality rates, by age group, sex, and place of residence, 1991 to most recent year.

Among men in the United States, those aged 75 years and older have the highest death rate from suicide among all age groups. In 2022, the suicide death rate among men aged 75 years and older was 43.9 per 100,000 population. In comparison, the death rate from suicide among men aged 25 to 44 years was 29.6 per 100,000. Suicide is a significant problem in the United States, with rates increasing over the past decade. Suicide among men In the United States, the suicide rate among men is almost four times higher than that of women. In 2022, the rate of suicide among U.S. men was 23 per 100,000 population, the highest rate recorded over the past 70 years. Firearms account for the vast majority of suicide deaths among men, accounting for around 60 percent of male suicides in 2021. The reasons why U.S. men have higher rates of suicide than women are complex and not fully understood, but may have to do with the more violent means by which men carry out suicide and the stigma around seeking help for mental health issues. Suicide among women Although the suicide rate among women in the U.S. is significantly lower than that of men, the rate of suicide among women has increased over the past couple of decades. Among women, those aged 45 to 64 years have the highest death rates due to suicide, followed by women 25 to 44 years old. Interestingly, the share of women reporting serious thoughts of suicide in the past year is higher than that of men, with around 5.5 percent of U.S. women reporting such thoughts in 2023. Similarly to men, firearms account for most suicide deaths among women, however suffocation and poisoning account for a significant share of suicides among women. In 2021, around 35 percent of suicides among women were carried out by firearms, while suffocation and poisoning each accounted for around 28 percent of suicide deaths.

Some racial and ethnic categories are suppressed for privacy and to avoid misleading estimates when the relative standard error exceeds 30% or the unweighted sample size is less than 50 respondents. Margins of error are estimated at the 90% confidence level.

Data Source: Centers for Disease Control and Prevention (CDC). Behavioral Risk Factor Surveillance System Survey (BRFSS) Data

Why This Matters

Colorectal cancer is the third leading cause of cancer death in the U.S. for men and women. Although colorectal cancer is most common among people aged 65 to 74, there has been an increase in incidences among people aged 40 to 49.

Nationally, Black people are disproportionately likely to both have colorectal cancer and die from it. Hispanic residents, and especially those with limited English proficiency, report having the lowest rate of colorectal cancer screenings.

Racial disparities in education, poverty, health insurance coverage, and English language proficiency are all factors that contribute to racial gaps in receiving colorectal cancer screenings. Increased colorectal cancer screening utilization has been shown to nearly erase the racial disparities in the death rate of colorectal cancer.

The District Response

The Colorectal Cancer Control Program (DC3C) aims to reduce colon cancer incidence and mortality by increasing colorectal cancer screening rates among District residents.

DC Health’s Cancer and Chronic Disease Prevention Bureau works with healthcare providers to improve the use of preventative health services and provide colorectal cancer screening services.

DC Health maintains the District of Columbia Cancer Registry (DCCR) to track cancer incidences, examine environmental substances that cause cancer, and identify differences in cancer incidences by age, gender, race, and geographical location.

BackgroundRandomized controlled trials have shown the importance of tight glucose control in type 1 diabetes (T1DM), but few recent studies have evaluated the risk of cardiovascular disease (CVD) and all-cause mortality among adults with T1DM. We evaluated these risks in adults with T1DM compared with the non-diabetic population in a nationwide study from Scotland and examined control of CVD risk factors in those with T1DM. Methods and FindingsThe Scottish Care Information-Diabetes Collaboration database was used to identify all people registered with T1DM and aged ≥20 years in 2005–2007 and to provide risk factor data. Major CVD events and deaths were obtained from the national hospital admissions database and death register. The age-adjusted incidence rate ratio (IRR) for CVD and mortality in T1DM (n = 21,789) versus the non-diabetic population (3.96 million) was estimated using Poisson regression. The age-adjusted IRR for first CVD event associated with T1DM versus the non-diabetic population was higher in women (3.0: 95% CI 2.4–3.8, p<0.001) than men (2.3: 2.0–2.7, p<0.001) while the IRR for all-cause mortality associated with T1DM was comparable at 2.6 (2.2–3.0, p<0.001) in men and 2.7 (2.2–3.4, p<0.001) in women. Between 2005–2007, among individuals with T1DM, 34 of 123 deaths among 10,173 who were <40 years and 37 of 907 deaths among 12,739 who were ≥40 years had an underlying cause of death of coma or diabetic ketoacidosis. Among individuals 60–69 years, approximately three extra deaths per 100 per year occurred among men with T1DM (28.51/1,000 person years at risk), and two per 100 per year for women (17.99/1,000 person years at risk). 28% of those with T1DM were current smokers, 13% achieved target HbA1c of <7% and 37% had very poor (≥9%) glycaemic control. Among those aged ≥40, 37% had blood pressures above even conservative targets (≥140/90 mmHg) and 39% of those ≥40 years were not on a statin. Although many of these risk factors were comparable to those previously reported in other developed countries, CVD and mortality rates may not be generalizable to other countries. Limitations included lack of information on the specific insulin therapy used. ConclusionsAlthough the relative risks for CVD and total mortality associated with T1DM in this population have declined relative to earlier studies, T1DM continues to be associated with higher CVD and death rates than the non-diabetic population. Risk factor management should be improved to further reduce risk but better treatment approaches for achieving good glycaemic control are badly needed. Please see later in the article for the Editors' Summary

The number of road traffic casualties divided by the population of the area in thousands multiplied by 100. This indicator contains data from all ‘types’ of road user, including pedestrians, pedal cyclists, motorcyclists, car users, and other vehicle users. Motor vehicle traffic accidents are a major cause of preventable deaths and morbidity, particularly in younger age groups. For children and for men aged 20-64 years, mortality rates for motor vehicle traffic accidents are higher in lower socioeconomic groups. For instance, there would be 600 fewer deaths in men aged 20-64 years from motor vehicle traffic accidents each year if all men had the same death rates as those in social classes I and II combined. There is evidence that some groups, like children, old people and potential cyclists, avoid roads because they are dangerous, which can reduce casualties but lower the quality of life. Ideally, casualty data need to be combined with other information. For example, a rise in journeys on foot and bicycle combined with a fall in accidents would indicate real progress. One of the Department for Transport’s PSA targets is to reduce the number of people killed or seriously injured in Great Britain in road accidents by 40 % by 2010 and the number of children killed or seriously injured by 50 % by 2010, compared with the averages for 1994-1998. Legacy unique identifier: P01049

Objective: To study the differences in clinical characteristics, risk factors, and complications across age-groups among the inpatients with the coronavirus disease 2019 (COVID-19).Methods: In this population-based retrospective study, we included all the positive hospitalized patients with COVID-19 at Wuhan City from December 29, 2019 to April 15, 2020, during the first pandemic wave. Multivariate logistic regression analyses were used to explore the risk factors for death from COVID-19. Canonical correlation analysis (CCA) was performed to study the associations between comorbidities and complications.Results: There are 36,358 patients in the final cohort, of whom 2,492 (6.85%) died. Greater age (odds ration [OR] = 1.061 [95% CI 1.057–1.065], p < 0.001), male gender (OR = 1.726 [95% CI 1.582–1.885], p < 0.001), alcohol consumption (OR = 1.558 [95% CI 1.355–1.786], p < 0.001), smoking (OR = 1.326 [95% CI 1.055–1.652], p = 0.014), hypertension (OR = 1.175 [95% CI 1.067–1.293], p = 0.001), diabetes (OR = 1.258 [95% CI 1.118–1.413], p < 0.001), cancer (OR = 1.86 [95% CI 1.507–2.279], p < 0.001), chronic kidney disease (CKD) (OR = 1.745 [95% CI 1.427–2.12], p < 0.001), and intracerebral hemorrhage (ICH) (OR = 1.96 [95% CI 1.323–2.846], p = 0.001) were independent risk factors for death from COVID-19. Patients aged 40–80 years make up the majority of the whole patients, and them had similar risk factors with the whole patients. For patients aged <40 years, only cancer (OR = 17.112 [95% CI 6.264–39.73], p < 0.001) and ICH (OR = 31.538 [95% CI 5.213–158.787], p < 0.001) were significantly associated with higher odds of death. For patients aged >80 years, only age (OR = 1.033 [95% CI 1.008–1.059], p = 0.01) and male gender (OR = 1.585 [95% CI 1.301–1.933], p < 0.001) were associated with higher odds of death. The incidence of most complications increases with age, but arrhythmias, gastrointestinal bleeding, and sepsis were more common in younger deceased patients with COVID-19, with only arrhythmia reaching statistical difference (p = 0.039). We found a relatively poor correlation between preexisting risk factors and complications.Conclusions: Coronavirus disease 2019 are disproportionally affected by age for its clinical manifestations, risk factors, complications, and outcomes. Prior complications have little effect on the incidence of extrapulmonary complications.

Protein-Protein, Genetic, and Chemical Interactions for Heijmans BT (1999):Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR). curated by BioGRID (https://thebiogrid.org); ABSTRACT: An elevated level of homocysteine in plasma is associated with the occurrence of cardiovascular disease. A common ala-to-val mutation in the methylenetetrahydrofolate reductase gene (MTHFR) is associated with an elevated level of plasma homocysteine. We studied the possible detrimental effects of the MTHFR mutation on mortality. Within a population-based study in the city of Leiden, the Netherlands, we first compared the MTHFR genotype distribution among 365 elderly subjects aged 85 years and over born in Leiden, and 250 young subjects aged 18 to 40 years whose families originated from the same geographical region. Second, the complete cohort of 666 subjects aged 85 years and over was followed over a period of 10 years for all-cause and cause-specific mortality and stratified according to MTHFR genotype. The frequency of the MTHFR mutation was significantly lower in the elderly than in the young (0.30 and 0.36, respectively; P = 0.03). The difference in genotype distribution was only present in men. The estimated mortality risk up to 85 years in men carrying the vallval genotype was 3.7 (95% confidence interval (CI), 1.3-10.9). Over the age of 85, mortality in men with the vallval genotype was increased 2.0-fold (95% CI, 1.1-3.9) and appeared to be attributable to cancer rather than cardiovascular causes of death. Among women aged 85 years and over, no deleterious effect of the MTHFR mutation was observed. In conclusion, the MTHFR mutation is associated with increased mortality in men in middle and old age, but not in women.

ObjectivesWe aimed to elucidate trends in the crude mortality rate (CMR), age-standardized mortality rate (ASMR), and burden of mental disorders (MD) in China.MethodsA longitudinal observational study was performed using the data of MD deaths in the National Disease Surveillance System (DSPs) during 2009–2019. The mortality rates were normalized using the Segis global population. Trends in the mortality of MDs stratified by age, gender, region, and residency, respectively. The burden of MD was evaluated using age-standardized person years of life loss per 100,000 people (SPYLLs) and average years of life lost (AYLL).ResultA total of 18,178 MD deaths occurred during 2009–2019, accounting for 0.13% of total deaths, and 68.3% of MD deaths occurred in rural areas. The CMR of MD in China was 0.75/100,00 persons (ASMR: 0.62/100,000 persons). The ASMR of all MDs decreased mainly due to the decrease in ASMR in rural residents. Schizophrenia and alcohol use disorder (AUD) were the leading causes of death in MD patients. The ASMR of schizophrenia and AUD was higher in rural residents than in urban residents. The ASMR of MD was highest in the 40–64 age group. As the leading causes of MD burden, the SPYLL and AYLL of schizophrenia were 7.76 person-years and 22.30 years, respectively.ConclusionAlthough the ASMR of all MDs decreased during 2009–2019, schizophrenia and AUD were still the most important causes of death for MDs. Targeted efforts focusing on men, rural residents, and the 40–64 years old population should be strengthened to decrease MD-related premature deaths.

Since the 1950s, the suicide rate in the United States has been significantly higher among men than women. In 2022, the suicide rate among men was almost four times higher than that of women. However, the rate of suicide for both men and women has increased gradually over the past couple of decades. Facts on suicide in the United States In 2022, the rate of suicide death in the United States was around 14 per 100,000 population. The suicide rate in the U.S. has generally increased since the year 2000, with the highest rates ever recorded in the years 2018 and 2022. In the United States, death rates from suicide are highest among those aged 45 to 64 years and lowest among younger adults aged 15 to 24. The states with the highest rates of suicide are Montana, Alaska, and Wyoming, while New Jersey and Massachusetts have the lowest rates. Suicide among men In 2023, around 4.5 percent of men in the United States reported having serious thoughts of suicide in the past year. Although this rate is lower than that of women, men still have a higher rate of suicide death than women. One reason for this may have to do with the method of suicide. Although firearms account for the largest share of suicide deaths among both men and women, firearms account for almost 60 percent of all suicides among men and just 35 percent among women. Suffocation and poisoning are the other most common methods of suicide among women, with the chances of surviving a suicide attempt from these methods being much higher than surviving an attempt by firearm. The age group with the highest rate of suicide death among men is by far those aged 75 years and over.

The leading causes of death among Black residents in the United States in 2022 included diseases of the heart, cancer, unintentional injuries, and stroke. The leading causes of death for African Americans generally reflects the leading causes of death for the entire United States population. However, a major exception is that death from assault or homicide is the seventh leading cause of death among African Americans, but is not among the ten leading causes for the general population. Homicide among African Americans The homicide rate among African Americans has been higher than that of other races and ethnicities for many years. In 2023, around 9,284 Black people were murdered in the United States, compared to 7,289 white people. A majority of these homicides are committed with firearms, which are easily accessible in the United States. In 2022, around 14,189 Black people died by firearms. However, suicide deaths account for over half of all deaths from firearms in the United States. Cancer disparities There are also major disparities in access to health care and the impact of various diseases. For example, the incidence rate of cancer among African American males is the greatest among all ethnicities and races. Furthermore, although the incidence rate of cancer is lower among African American women than it is among white women, cancer death rates are still higher among African American women.

Between the beginning of January 2020 and June 14, 2023, of the 1,134,641 deaths caused by COVID-19 in the United States, around 307,169 had occurred among those aged 85 years and older. This statistic shows the number of coronavirus disease 2019 (COVID-19) deaths in the U.S. from January 2020 to June 2023, by age.

In 2023, a woman in the United States aged 65 years could expect to live another **** years on average. This number decreased in the years 2020 and 2021, after reaching a high of **** years in 2019. Nevertheless, the life expectancy of a woman aged 65 years in the United States is still higher than that of a man of that age. In 2023, a man aged 65 years could be expected to live another 18.2 years on average. Why has the life expectancy in the U.S. declined? Overall, life expectancy in the United States has declined in recent years. In 2019, the life expectancy for U.S. women was **** years, but by 2023 it had decreased to **** years. Likewise, the life expectancy for men decreased from **** years to **** years in the same period. The biggest contributors to this decline in life expectancy are the COVID-19 pandemic and the opioid epidemic. Although deaths from the COVID-19 pandemic have decreased significantly since 2022, deaths from opioid overdose continue to increase, reaching all-time highs in 2022. The leading causes of death among U.S. women The leading causes of death among women in the United States in 2022 were heart disease, cancer, stroke, and COVID-19. That year, heart disease and cancer accounted for a combined **** percent of all deaths among women, while around *** percent of deaths were due to COVID-19. The overall leading causes of death in the United States generally reflect the leading causes among women, with some slight variations. For example, Alzheimer’s disease is the ***** leading cause of death among women but the ******* leading cause of death overall in the United States.

Number of suicide death and suicide rates in patients diagnosed with benign prostatic hyperplasia and general population without benign prostatic hyperplasia.

Hazard ratios (95% CI) for suicide among patients with benign prostatic hyperplasia compared to general population without benign prostatic hyperplasia.

Baseline characteristics of patients diagnosed with benign prostatic hyperplasia and general population without benign prostatic hyperplasia.