In the United States, the leading causes of death among women are heart disease and cancer. Heart disease and cancer are similarly the leading causes of death among U.S. men. In 2022, heart disease accounted for **** percent of all deaths among women in the United States, while cancer accounted for **** percent of deaths. COVID-19 was the third leading cause of death among both men and women in 2020 and 2021, and the fourth leading cause in 2022. Cancer among women in the U.S. The most common types of cancer among U.S. women are breast, lung and bronchus, and colon and rectum. In 2025, there were around ******* new breast cancer cases among women, compared to ******* new cases of lung and bronchus cancer. Although breast cancer is the most common form of cancer among women in the United States, lung and bronchus cancer causes the highest number of cancer deaths. In 2025, around ****** women were expected to die from lung and bronchus cancer, compared to ****** from breast cancer. Breast cancer Although breast cancer is the second most deadly form of cancer among women, rates of death have decreased over the past few decades. This decrease is possibly due to early detection, progress in therapy, and increasing awareness of risk factors. In 2023, the death rate due to breast cancer was **** per 100,000 population, compared to a rate of **** per 100,000 in the year 1990. The state with the highest rate of deaths due to breast cancer is Oklahoma, while South Dakota had the lowest rates.

As of 2022, the third leading cause of death among teenagers aged 15 to 19 years in the United States was intentional self-harm or suicide, contributing around 17 percent of deaths among age group. The leading cause of death at that time was unintentional injuries, contributing to around 37.4 percent of deaths, while 21.8 percent of all deaths in this age group were due to assault or homicide. Cancer and heart disease, the overall leading causes of death in the United States, are also among the leading causes of death among U.S. teenagers. Adolescent suicide in the United States In 2021, around 22 percent of students in grades 9 to 12 reported that they had seriously considered attempting suicide in the past year. Female students were around twice as likely to report seriously considering suicide compared to male students. In 2022, Montana had the highest rate of suicides among U.S. teenagers with around 39 deaths per 100,000 teenagers, followed by South Dakota with a rate of 33 per 100,000. The states with the lowest death rates among adolescents are New York and New Jersey. Mental health treatment Suicidal thoughts are a clear symptom of mental health issues. Mental health issues are not rare among children and adolescents, and treatment for such issues has become increasingly accepted and accessible. In 2021, around 15 percent of boys and girls aged 5 to 17 years had received some form of mental health treatment in the past year. At that time, around 35 percent of youths aged 12 to 17 years in the United States who were receiving specialty mental health services were doing so because they had thought about killing themselves or had already tried to kill themselves.

This dataset contains counts of deaths for California as a whole based on information entered on death certificates. Final counts are derived from static data and include out-of-state deaths to California residents, whereas provisional counts are derived from incomplete and dynamic data. Provisional counts are based on the records available when the data was retrieved and may not represent all deaths that occurred during the time period. Deaths involving injuries from external or environmental forces, such as accidents, homicide and suicide, often require additional investigation that tends to delay certification of the cause and manner of death. This can result in significant under-reporting of these deaths in provisional data.

The final data tables include both deaths that occurred in California regardless of the place of residence (by occurrence) and deaths to California residents (by residence), whereas the provisional data table only includes deaths that occurred in California regardless of the place of residence (by occurrence). The data are reported as totals, as well as stratified by age, gender, race-ethnicity, and death place type. Deaths due to all causes (ALL) and selected underlying cause of death categories are provided. See temporal coverage for more information on which combinations are available for which years.

The cause of death categories are based solely on the underlying cause of death as coded by the International Classification of Diseases. The underlying cause of death is defined by the World Health Organization (WHO) as "the disease or injury which initiated the train of events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury." It is a single value assigned to each death based on the details as entered on the death certificate. When more than one cause is listed, the order in which they are listed can affect which cause is coded as the underlying cause. This means that similar events could be coded with different underlying causes of death depending on variations in how they were entered. Consequently, while underlying cause of death provides a convenient comparison between cause of death categories, it may not capture the full impact of each cause of death as it does not always take into account all conditions contributing to the death.

The burden of influenza in the United States can vary from year to year depending on which viruses are circulating, how many people receive an influenza vaccination, and how effective the vaccination is in that particular year. During the 2023-2024 flu season, around 28,000 people lost their lives to the disease. Although most people recover from influenza without needing medical care, the disease can be deadly among young children, the elderly, and those with weakened immune systems or chronic illnesses. Deaths due to influenza Even though most people recover from influenza without medical care, influenza and pneumonia can be deadly, especially for older people and those with certain preexisting conditions. Influenza is a common cause of pneumonia and although most cases of influenza do not develop into pneumonia, those that do are often more severe and more deadly. Deaths due to influenza are most common among the elderly, with a mortality rate of around 32 per 100,000 population during the 2023-2024 flu season. In comparison, the mortality rate for those aged 50 to 64 years was 9.1 per 100,000 population. Flu vaccinations The most effective way to prevent influenza is to receive an annual influenza vaccination. These vaccines have proven to be safe and are usually cheap and easily accessible. Nevertheless, every year a large share of the population in the United States still fails to get vaccinated against influenza. For example, in the 2022-2023 flu season, only 35 percent of those aged 18 to 49 years received a flu vaccination. Unsurprisingly, children and the elderly are the most likely to get vaccinated. It is estimated that during the 2022-2023 flu season, vaccinations prevented over 929 thousand influenza cases among children aged 6 months to 4 years.

The deadliest animals in the world based on the number of human deaths per year is not a creature that humans usually find scary, such as a lion or snake. Mosquitos are by far the deadliest creature in the world when it comes to annual human deaths, causing around one million deaths per year, compared to 100,000 deaths from snakes and 250 from lions. Perhaps surpringly, dogs are the third deadliest animal to humans. Dogs are responsible for around 30,000 human deaths per year, with the vast majority of these deaths resulting from rabies that is transmitted from the dog.

Malaria

Mosquitos are the deadliest creature in the world because they transmit a number of deadly diseases, the worst of which is malaria. Malaria is a mosquito-borne disease caused by a parasite that results in fever, chills, headache, vomiting and, if left untreated, death. Malaria disproportionately affects poorer regions of the world such as Africa and South-East Asia. In 2020, there were around 627,000 deaths from malaria worldwide.

Mosquito-borne diseases in the U.S.

The most common mosquito-borne diseases reported in the United States include West Nile virus, malaria, and dengue viruses. Many of these cases, however, are from travelers who contracted the disease in another country - this is especially true for malaria, Zika, and dengue. In 2018, the states of California, New York, and Texas reported the highest number of mosquito-borne disease cases in the United States.

We describe the results of a prospective observational study of the clinical natural history of human monkeypox (mpox) virus (MPXV) infections at the remote L’Hopital General de Reference de Kole (Kole hospital), the rainforest of the Congo River basin of the Democratic Republic of the Congo (DRC) from March 2007 until August 2011. The research was conducted jointly by the Institute National de Recherche Biomedical (INRB) and the US Army Medical Research Institute of Infectious Diseases (USAMRIID). The Kole hospital was one of the two previous WHO Mpox study sites (1981–1986). The hospital is staffed by a Spanish Order of Catholic Nuns from La Congregation Des Soeurs Missionnaires Du Christ Jesus including two Spanish physicians, who were members of the Order as well, were part of the WHO study on human mpox. Of 244 patients admitted with a clinical diagnosis of MPXV infection, 216 were positive in both the Pan-Orthopox and MPXV specific PCR. The cardinal observations of these 216 patients are summarized in this report. There were three deaths (3/216) among these hospitalized patients; fetal death occurred in 3 of 4 patients who were pregnant at admission, with the placenta of one fetus demonstrating prominent MPXV infection of the chorionic villi. The most common complaints were rash (96.8%), malaise (85.2%), sore throat (78.2%), and lymphadenopathy/adenopathy (57.4%). The most common physical exam findings were mpox rash (99.5%) and lymphadenopathy (98.6%). The single patient without the classic mpox rash had been previously vaccinated against smallpox. Age group of less than 5 years had the highest lesion count. Primary household cases tended to have higher lesion counts than secondary or later same household cases. Of the 216 patients, 200 were tested for IgM & IgG antibodies (Abs) to Orthopoxviruses. All 200 patients had anti-orthopoxvirus IgG Abs; whereas 189/200 were positive for IgM. Patients with hypoalbuminemia had a high risk of severe disease. Patients with fatal disease had higher maximum geometric mean values than survivors for the following variables, respectively: viral DNA in blood (DNAemia); maximum lesion count; day of admission mean AST and ALT.

The mortality rate from influenza in the United States is by far highest among those aged 65 years and older. During the 2023-2024 flu season, the mortality rate from influenza for this age group was around 32.1 per 100,000 population. The burden of influenza The impact of influenza in the U.S. varies from season to season, but in the 2023-2024 flu season, there were an estimated 40 million cases. These cases resulted in around 470,000 hospitalizations. Although most people recover from influenza without requiring medical treatment, the disease can be deadly for young children, the elderly, and those with weakened immune systems or chronic illnesses. During the 2023-2024 flu season, around 28,000 people in the U.S. lost their lives due to influenza. Impact of vaccinations The most effective way to prevent influenza is to receive an annual vaccination at the beginning of flu season. Flu vaccines are safe and can greatly reduce the burden of the disease. During the 2022-2023 flu season, vaccinations prevented around 2,479 deaths among those aged 65 years and older. Although flu vaccines are usually cheap and easily accessible, every year a large share of the population in the U.S. still does not get vaccinated. For example, during the 2022-2023 flu season, only about 35 percent of those aged 18 to 49 years received a flu vaccination.

Over the last few years, gun violence in the United States has become an increasingly deadly public health crisis. In 2021, firearms were the leading cause of death for children and adolescents aged one to 19 years old for a second year in a row in the United States, with ***** deaths from firearms, which accounted for more deaths than car crashes and other diseases in that year. This is an increase from the previous year, when there were ***** deaths from firearms. Gun violence in the U.S. Along with a rise in gun-related deaths, the United States has been experiencing an overall increase in gun violence, including mass shootings, school shootings, and gun homicides. Not surprisingly, the United States has also reported in increase in gun sales, with the unit sales for firearms reaching a new high in recent years. A uniquely American problem Despite the rise of gun violence and gun-related deaths, guns remain easily accessible in the United States and gun control has become a divisive issue throughout the nation. However, gun control proponents often call attention to the uniquely American phenomenon of school shootings. Since 2018, the annual number of incidents involving firearms at K-12 schools in the U.S. reached over *** in each year, while similar incidents in other countries with strict gun laws are exceptionally rare.

Handguns are by far the most common murder weapon used in the United States, accounting for 7,159 homicides in 2023. This is followed by firearms of an unstated type, with 5,295 cases in that year. Why do murders happen in the U.S.? While most of the time the circumstances of murders in the U.S. remain unknown, homicides due to narcotics come in as the second most common circumstance – making them more common than, for example, gang killings. Despite these gruesome facts, the violent crime rate has fallen significantly since 1990, and the United States is much safer than it was in the 1980s and 1990s. Knife crime vs disease: Leading causes of death The death rate in the U.S. had hovered around the same level since 1990 until there was a large increase due to the COVID-19 pandemic in recent years. Heart disease, cancer, and accidents were the three leading causes of death in the country in 2022. The rate of death from heart disease is significantly higher than the homicide rate in the United States, at 167.2 deaths per 100,000 population compared to a 5.7 homicides per 100,000. Given just 1,562 murders were caused by knife crime, it is fair to say that heart disease is a far bigger killer in the U.S.

COVID-19 was first detected in Brazil on March 1, 2020, making it the first Latin American country to report a case of the novel coronavirus. Since then, the number of infections has risen drastically, reaching approximately 38 million cases by May 11, 2025. Meanwhile, the first local death due to the disease was reported in March 19, 2020. Four years later, the number of fatal cases had surpassed 700,000. The highest COVID-19 death toll in Latin America With a population of more than 211 million inhabitants as of 2023, Brazil is the most populated country in Latin America. This nation is also among the most affected by COVID-19 in number of deaths, not only within the Latin American region, but also worldwide, just behind the United States. These figures have raised a debate on how the Brazilian government has dealt with the pandemic. In fact, according to a study carried out in May 2021, more than half of Brazilians surveyed disapproved of the way in which former president Jair Bolsonaro had been dealing with the health crisis. In comparison, a third of respondents had a similar opinion about the Ministry of Health. Brazil’s COVID-19 vaccination campaign rollout Brazil’s vaccination campaign started at the beginning of 2021, when a nurse from São Paulo became the first person in the country to get vaccinated against the disease. A few years later, roughly 88 percent of the Brazilian population had received at least one vaccine dose, while around 81 percent had already completed the basic immunization scheme. With more than 485.2 million vaccines administered as of March 2023, Brazil was the fourth country with the most administered doses of the COVID-19 vaccine globally, after China, India, and the United States.Find the most up-to-date information about the coronavirus pandemic in the world under Statista’s COVID-19 facts and figures site.