Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of IgG subclasses. We measured total IgG and IgG subclasses by quantitative suspension array technology against 14 pathogens and vaccine antigens, including targets of maternal immunization, in 341 delivering HIV-uninfected and HIV-infected mother-infant pairs from southern Mozambique. We analyzed the association of maternal HIV infection, Plasmodium falciparum exposure, maternal variables and pregnancy outcomes on cord antibody levels and transplacental transfer. Our results show that maternal antibody levels were the main determinant of cord antibody levels. Univariable and multivariable analysis showed that HIV reduced the placental transfer and cord levels of IgG and IgG1 principally, but also IgG2 to half of the antigens tested. P. falciparum exposure and prematurity were negatively associated with cord antibody levels and placental transfer, but this was antigen-subclass dependent. Our findings suggest that lower maternally transferred antibodies may underlie increased susceptibility to infections of HIV-exposed infants. This could affect efficacy of maternal vaccination, especially in sub-Saharan Africa, where there is a high prevalence of HIV, malaria and unfavorable environmental factors.

An adequate food supply is widely recognized as a necessary condition for social development as well as a basic human right. Food deficits are especially common among semi-subsistence farming households in eastern and southern Africa and farm productivity is widely regarded as the locus for enhancing household food outcomes. However, knowledge gaps surrounding benefits associated with climate smart, productivity-enhancing technologies require attention. This study evaluates benefits associated with sustainable intensification farm management practices (crop residue retention, minimum tillage, manure application and use of herbicides, pesticides, fertilizer, and improved seeds) for household calorie and protein supplies and demonstrates their scope across households with high-, moderate- and low- likelihoods of calorie and protein deficits. Household-level calorie and protein deficits were estimated from survey data on food production, acquisition and consumption for households in Ethiopia and Mozambique. Multinomial logistic models were used to identify drivers of household food deficit status and logistic model trees established “rules of thumb” to classify households by food deficit status as low, moderate or high likelihood. In Ethiopia, especially wet seasons were associated with a high likelihood of a food deficit while especially dry seasons were associated with a high likelihood of food deficit in Mozambique. The practices associated with sustainable intensification and related technologies substantially enhanced food outcomes in groups with a high- and a low-likelihood of food deficit, and associated benefits were high for the best-off households. Benefits associated with sustainable intensification technologies were not observed for households with a moderate likelihood of a food deficit and some technologies even increased risk. The sustainable intensification practices assessed here were associated with improved food outcomes yet benefits were limited in scope for households of intermediate status. Thus, there is a need to expand the technical options available to reduce food deficit.

This Project Tycho dataset includes a CSV file with COVID-19 data reported in MOZAMBIQUE: 2020-01-03 - 2021-07-31. It contains counts of cases and deaths. Data for this Project Tycho dataset comes from: "COVID-19 Data Repository by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University", "European Centre for Disease Prevention and Control Website", "World Health Organization COVID-19 Dashboard". The data have been pre-processed into the standard Project Tycho data format v1.1.

Records of reported Counts of COVID-19 case counts in Mozambique from 2020-2021. Download is a zipped CSV file with readme.

Maternal factors and exposure to pathogens have an impact on infant health. For instance, HIV exposed but uninfected infants have higher morbidity and mortality than HIV unexposed infants. Innate responses are the first line of defense and orchestrate the subsequent adaptive immune response and are especially relevant in newborns. To determine the association of maternal HIV infection with maternal and newborn innate immunity we analyzed the cytokine responses upon pattern recognition receptor (PRR) stimulations in the triad of maternal peripheral and placental blood as well as in cord blood in a cohort of mother-infant pairs from southern Mozambique. A total of 48 women (35 HIV-uninfected and 13 HIV-infected) were included. Women and infant innate responses positively correlated with each other. Age, gravidity and sex of the fetus had some associations with spontaneous production of cytokines in the maternal peripheral blood. HIV-infected women not receiving antiretroviral therapy (ART) before pregnancy showed decreased IL-8 and IL-6 PRR responses in peripheral blood compared to those HIV-uninfected, and PRR hyporesponsiveness for IL-8 was also found in the corresponding infant’s cord blood. HIV infection had a greater impact on placental blood responses, with significantly increased pro-inflammatory, TH1 and TH17 PRR responses in HIV-infected women not receiving ART before pregnancy compared to HIV-uninfected women. In conclusion, innate response of the mother and her newborn was altered by HIV infection in the women who did not receive ART before pregnancy. As these responses could be related to birth outcomes, targeted innate immune modulation could improve maternal and newborn health.