1999-2008; 2005-2008. This dataset is a de-identified summary table of vision and eye health data indicators from NHANES, stratified by all available combinations of age group, race/ethnicity, gender, and risk factor. NHANES is a program of studies conducted by the National Center for Health Statistics at CDC designed to assess the health and nutritional status of adults and children in the U.S, and combines interviews and physical examinations. NHANES stopped collecting vision and eye health data in 2008. Approximate sample size is 5,000 persons per year. NHANES data for VEHSS includes questions and examinations related to Visual Function, Vision Exam Measures, Eye Health Conditions, Service Utilization, and Examination Measures. Data were suppressed for cell sizes less than 30 persons, or where the relative standard error more than 30% of the mean. Detailed information on VEHSS NHANES analyses can be found on the VEHSS NHANES webpage (https://www.cdc.gov/visionhealth/vehss/data/national-surveys/national-health-and-nutrition-examination-survey.html). Additional information about NHANES can be found on the NHANES website (https://www.cdc.gov/nchs/nhanes/index.htm). The VEHSS NHANES dataset was last updated in June 2018.

Analysis of ‘National Health and Nutrition Examination Survey (NHANES) – Vision and Eye Health Surveillance’ provided by Analyst-2 (analyst-2.ai), based on source dataset retrieved from https://catalog.data.gov/dataset/17db5667-8dc2-48f5-aba9-e42cbb10a1f2 on 12 February 2022.

--- Dataset description provided by original source is as follows ---

1999-2008; 2005-2008. This dataset is a de-identified summary table of vision and eye health data indicators from NHANES, stratified by all available combinations of age group, race/ethnicity, gender, and risk factor. NHANES is a program of studies conducted by the National Center for Health Statistics at CDC designed to assess the health and nutritional status of adults and children in the U.S, and combines interviews and physical examinations. NHANES stopped collecting vision and eye health data in 2008. Approximate sample size is 5,000 persons per year. NHANES data for VEHSS includes questions and examinations related to Visual Function, Vision Exam Measures, Eye Health Conditions, Service Utilization, and Examination Measures. Data were suppressed for cell sizes less than 30 persons, or where the relative standard error more than 30% of the mean. Detailed information on VEHSS NHANES analyses can be found on the VEHSS NHANES webpage (https://www.cdc.gov/visionhealth/vehss/data/national-surveys/national-health-and-nutrition-examination-survey.html). Additional information about NHANES can be found on the NHANES website (https://www.cdc.gov/nchs/nhanes/index.htm). The VEHSS NHANES dataset was last updated in June 2018.

--- Original source retains full ownership of the source dataset ---

BackgroundHeavy metals exposure has been widely referred to as a risk factor for human health. However, studies on the potential impact of heavy metals on visual disability are limited. Herein, this study aims to investigate the associations of urinary and blood heavy metals with visual disability in adults.MethodsA total of 4,284 eligible participants in the 2013–2018 National Health and Nutrition Examination Survey (NHANES) were enrolled in our cross-sectional study. The urinary barium (Ba), cadmium (Cd), cesium (Cs), cobalt (Co), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), tin (Sn), tungsten (Tu), and mercury (Hg) and blood Pb, Cd, and Hg were included for analysis. We used multivariate logistic regression, weighted quantile sum (WQS) regression, quantile-based gcomputation (qgcomp) regression, and Bayesian kernel machine regression (BKMR) to assess the mixed-metal effect on visual disability. The subgroup analysis was stratified by age.ResultsIn the single metal exposure model, the risk of visual disability increased by 39.2%, 22.6%, 25.6%, and 17.9% for each unit increase in urinary Cd, Pb, Sn, and Tu, respectively (all p < 0.05). Meanwhile, the risk of visual disability increased by 40.6% and 22.7% per unit increase in blood Ln-Pb and Ln-Cd, respectively (p = 0.034 and 0.018). In mixed metal effect analysis, WQS, qgcomp, and BKMR models consistently demonstrated a positive association between blood and urine metal co-exposure and visual disability. Furthermore, we found that Cd and Pb were the top-weighted metals responsible for the overall effect. However, these associations were not pronounced in the older adults.ConclusionsOur findings suggested that Cd, Pb, Sn, and Tu were identified as independent risk factors for visual disability. Furthermore, exposure to mixed metals could increase the risk of visual disability, to which Cd and Pb were the greatest contributors.