In 2019, the number of incident cases of Down syndrome worldwide was around ******. At that time, South Asia had the highest number of new Down Syndrome cases worldwide. This statistic shows the number of incidence cases of Down syndrome worldwide in 1990 and 2019, by region.

COVID-19: No. of Tests: Serious Cases: New: by State: North: Tocantins: Ignored data was reported at 0.000 Unit in 28 Mar 2025. This stayed constant from the previous number of 0.000 Unit for 27 Mar 2025. COVID-19: No. of Tests: Serious Cases: New: by State: North: Tocantins: Ignored data is updated daily, averaging 0.000 Unit from Aug 2002 (Median) to 28 Mar 2025, with 8247 observations. The data reached an all-time high of 0.000 Unit in 28 Mar 2025 and a record low of 0.000 Unit in 28 Mar 2025. COVID-19: No. of Tests: Serious Cases: New: by State: North: Tocantins: Ignored data remains active status in CEIC and is reported by Ministry of Health. The data is categorized under Brazil Premium Database’s Health Sector – Table BR.HLA003: Disease Outbreaks: COVID-19: Number of Tests: Serious Cases.

Collected COVID-19 datasets from various sources as part of DAAN-888 course, Penn State, Spring 2022. Collaborators: Mohamed Abdelgayed, Heather Beckwith, Mayank Sharma, Suradech Kongkiatpaiboon, and Alex Stroud

**1 - COVID-19 Data in the United States ** Source: The data is collected from multiple public health official sources by NY Times journalists and compiled in one single file. Description: Daily count of new COVID-19 cases and deaths for each state. Data is updated daily and runs from 1/21/2020 to 2/4/2022. URL: https://github.com/nytimes/covid-19-data/blob/master/us-states.csv Data size: 38,814 row and 5 columns.

**2 - Mask-Wearing Survey Data ** Source: The New York Times is releasing estimates of mask usage by county in the United States. Description: This data comes from a large number of interviews conducted online by the global data and survey firm Dynata, at the request of The New York Times. The firm asked a question about mask usage to obtain 250,000 survey responses between July 2 and July 14, enough data to provide estimates more detailed than the state level. URL: https://github.com/nytimes/covid-19-data/blob/master/mask-use/mask-use-by-county.csv Data size: 3,142 rows and 6 columns

**3a - Vaccine Data – Global ** Source: This data comes from the US Centers for Disease Control and Prevention (CDC), Our World in Data (OWiD) and the World Health Organization (WHO). Description: Time series data of vaccine doses administered and the number of fully and partially vaccinated people by country. This data was last updated on February 3, 2022 URL: https://github.com/govex/COVID-19/blob/master/data_tables/vaccine_data/global_data/time_series_covid19_vaccine_global.csv
Data Size: 162,521 rows and 8 columns

**3b -Vaccine Data – United States ** Source: The data is comprised of individual State's public dashboards and data from the US Centers for Disease Control and Prevention (CDC). Description: Time series data of the total vaccine doses shipped and administered by manufacturer, the dose number (first or second) by state. This data was last updated on February 3, 2022. URL: https://github.com/govex/COVID-19/blob/master/data_tables/vaccine_data/us_data/time_series/vaccine_data_us_timeline.csv
Data Size: 141,503 rows and 13 columns

**4 - Testing Data ** Source: The data is comprised of individual State's public dashboards and data from the U.S. Department of Health & Human Services. Description: Time series data of total tests administered by county and state. This data was last updated on January 25, 2022. URL: https://github.com/govex/COVID-19/blob/master/data_tables/testing_data/county_time_series_covid19_US.csv
Data size: 322,154 rows and 8 columns

**5 – US State and Territorial Public Mask Mandates ** Source: Data from state and territory executive orders, administrative orders, resolutions, and proclamations is gathered from government websites and cataloged and coded by one coder using Microsoft Excel, with quality checking provided by one or more other coders. Description: US State and Territorial Public Mask Mandates from April 10, 2020 through August 15, 2021 by County by Day URL: https://data.cdc.gov/Policy-Surveillance/U-S-State-and-Territorial-Public-Mask-Mandates-Fro/62d6-pm5i Data Size: 1,593,869 rows and 10 columns

**6 – Case Counts & Transmission Level ** Source: This open-source dataset contains seven data items that describe community transmission levels across all counties. This dataset provides the same numbers used to show transmission maps on the COVID Data Tracker and contains reported daily transmission levels at the county level. The dataset is updated every day to include the most current day's data. The calculating procedures below are used to adjust the transmission level to low, moderate, considerable, or high.
Description: US State and County case counts and transmission level from 16-Aug-2021 to 03-Feb-2022 URL: https://data.cdc.gov/Public-Health-Surveillance/United-States-COVID-19-County-Level-of-Community-T/8396-v7yb Data Size: 550,702 rows and 7 columns

**7 - World Cases & Vaccination Counts ** Source: This is an open-source dataset collected and maintained by Our World in Data. OWID provides research and data to help against the world’s largest problems.
Description: This dataset includes vaccinations, tests & positivity, hospital & ICU, confirmed cases, confirmed deaths, reproduction rate, policy responses and other variables of interest. URL: https://github.com/owid/covid-19-data/tree/master/public/data Data Size: 67 columns and 157,000 rows

**8 - COVID-19 Data in the European Union ** Source: This is an open-source dataset collected and maintained by ECDC. It is an EU agency aimed at strengthening Europe's defenses against infectious diseases.
Description: This dataset co...

In 2022, the WHO African region had the highest prevalence and number of persons living with chronic viral hepatitis B virus infection. This statistic shows the prevalence of chronic viral hepatitis B in the general population as of 2022, by WHO region.

COVID-19: No. of Tests: Serious Cases: New: by State: Central-West: Mato Grosso: Ignored data was reported at 0.000 Unit in 28 Mar 2025. This stayed constant from the previous number of 0.000 Unit for 27 Mar 2025. COVID-19: No. of Tests: Serious Cases: New: by State: Central-West: Mato Grosso: Ignored data is updated daily, averaging 0.000 Unit from Aug 2002 (Median) to 28 Mar 2025, with 8247 observations. The data reached an all-time high of 0.000 Unit in 28 Mar 2025 and a record low of 0.000 Unit in 28 Mar 2025. COVID-19: No. of Tests: Serious Cases: New: by State: Central-West: Mato Grosso: Ignored data remains active status in CEIC and is reported by Ministry of Health. The data is categorized under Brazil Premium Database’s Health Sector – Table BR.HLA003: Disease Outbreaks: COVID-19: Number of Tests: Serious Cases.

The single largest use case in terms of number of Internet of Things (IoT) connected devices is consumer internet and media devices, accounting for a third of all devices worldwide in 2034. The other two largest use cases are smart grid (e.g. smart meters) and inventory management & monitoring.

COVID-19: No. of Tests: Serious Cases: New: RT-PCR Tests: by State: Northeast: Rio Grande do Norte: Result: Waiting for Result data was reported at 0.000 Unit in 28 Mar 2025. This stayed constant from the previous number of 0.000 Unit for 27 Mar 2025. COVID-19: No. of Tests: Serious Cases: New: RT-PCR Tests: by State: Northeast: Rio Grande do Norte: Result: Waiting for Result data is updated daily, averaging 0.000 Unit from Aug 2002 (Median) to 28 Mar 2025, with 8247 observations. The data reached an all-time high of 10.000 Unit in 28 Jul 2020 and a record low of 0.000 Unit in 28 Mar 2025. COVID-19: No. of Tests: Serious Cases: New: RT-PCR Tests: by State: Northeast: Rio Grande do Norte: Result: Waiting for Result data remains active status in CEIC and is reported by Ministry of Health. The data is categorized under Brazil Premium Database’s Health Sector – Table BR.HLA003: Disease Outbreaks: COVID-19: Number of Tests: Serious Cases.

For females of all ages, the total number of new cancer cases worldwide was estimated to be approximately 9.66 million in 2022. Breast cancer accounted for around 24 percent of all new cancer cases among females at that time. This statistic displays the estimated number of new cancer cases among females worldwide in 2022, sorted by type of cancer.

BackgroundAcute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with a significant global burden. This study evaluates global, regional, and national trends in the prevalence, mortality, and disability-adjusted life years (DALYs) of childhood ALL from 1990 to 2021, providing insights into disparities and progress across different socio-demographic and geographic contexts.MethodsData were sourced from the Global Burden of Disease study. Trends in prevalence, mortality, and DALYs were analyzed by socio-demographic index (SDI) regions, geographic areas, and countries. Estimated annual percentage changes (EAPCs) were used to quantify temporal trends.FindingsBetween 1990 and 2021, the global number of childhood ALL cases increased by 59.06%, reaching 168,879 cases in 2021, while ALL-related deaths and DALYs decreased by 66.71% and 66.13%, respectively. High- and high-middle SDI regions demonstrated significant improvements, driven by advances in healthcare and early diagnosis. In contrast, low-SDI regions faced persistent challenges, with a slight increase in DALYs observed in 2021. Geographic disparities were pronounced, with East Asia achieving the largest reductions in mortality and DALYs, whereas Sub-Saharan Africa and the Caribbean remained heavily burdened.InterpretationDespite progress in reducing mortality and DALYs globally, the rising prevalence of ALL and persistent disparities in low-SDI regions highlight the urgent need for equitable access to healthcare, early diagnosis, and effective treatment strategies. Strengthening healthcare infrastructure and fostering global collaboration are critical to further mitigating the burden of childhood ALL and ensuring equitable outcomes worldwide.

BackgroundNon-rheumatic valvular heart disease (NRVHD), driven by aging populations and epidemiological transitions, has become the dominant form of valvular heart disease globally, yet its burden trends and demographic disparities remain undercharacterized. This study quantifies the global and Chinese burden of NRVHD from 1990 to 2021, analyzing age-sex disparities and temporal trends.MethodsUsing data from the Global Burden of Disease (GBD) 2021 Study. First, the number of incidence, prevalence, deaths, and disability-adjusted life years (DALYs) cases, along with their corresponding age-standardized rates (ASRs), were reported globally and in China, stratified by different sub-types in 2021. These sub-types included sex and age groups. Second, to explore the temporal trend of the disease burden, data from 1990 to 2021 were analyzed both globally and by sub-types. The estimated annual percentage change (EAPC) value was calculated using a linear regression model.ResultsIn 2021, NRVHD caused 2,206,928 global incidence cases (ASR: 25.0/100,000) and 28.4 million prevalence cases (ASR: 335.3/100,000), with 181,078 deaths (ASR: 2.31/100,000) and 3.24 million DALYs (ASR: 39.7/100,000). China accounted for 292,215 incidence cases (ASR: 12.8/100,000) and 3.28 million prevalence cases (ASR: 156.2/100,000), demonstrating lower deaths cases (ASDR: 0.13 vs. global 2.31/100,000) but accelerated burden growth. From 1990 to 2021, global incidence rose 129%, while China's surged 220%. Age-standardized deaths rate declined globally and in China, contrasting with rising prevalence. Males bore higher burdens globally and in China, with elderly populations disproportionately affected.ConclusionNRVHD burden has escalated globally, characterized by rising morbidity amid declining mortality, a paradox amplified in China. While therapeutic advances and hypertension control contributed to mortality reductions, persistent sex-age disparities and rural-urban inequities demand targeted strategies. China's rapid epidemiological transition underscores the urgency of integrating primary prevention, equitable technology access, and enhanced surveillance to address aging-related valvulopathies.

This statistic depicts the number of people with anxiety disorders worldwide as of 2015, by WHO region. According to the data, South-East Asia had ***** million people who suffered from an anxiety disorder as of 2015.

Snapshot img

Bone Cement Market Size 2025-2029

The bone cement market size is valued to increase USD 574.9 million, at a CAGR of 6% from 2024 to 2029. Growing prevalence of orthopedic disorders due to rise in trauma cases will drive the bone cement market.

Major Market Trends & Insights

North America dominated the market and accounted for a 42% growth during the forecast period.
By Product - Antibiotic-loaded bone cement segment was valued at USD 1006.90 million in 2023
By End-user - Hospitals segment accounted for the largest market revenue share in 2023

Market Size & Forecast

Market Opportunities: USD 68.27 million
Market Future Opportunities: USD 574.90 million
CAGR from 2024 to 2029: 6%

Market Summary

The market has experienced significant expansion due to the increasing prevalence of orthopedic disorders, driven primarily by the rising number of trauma cases worldwide. This trend is further fueled by the growing focus on bioresorbable materials, which offer advantages such as reduced complications and improved patient outcomes. However, the use of bone cement is not without challenges. Complications, including cement leakage and allergic reactions, continue to pose significant hurdles for market growth. Despite these challenges, innovation remains a key driver, with ongoing research into advanced formulations and delivery systems aimed at enhancing the functionality and safety of bone cement.
The market's future direction lies in the development of more effective, patient-specific solutions that address the unique needs of each patient, ultimately leading to better clinical outcomes and improved quality of life. According to a recent study, the market was valued at over USD 3 billion in 2020, underscoring its importance in the orthopedic industry.

What will be the Size of the Bone Cement Market during the forecast period?

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How is the Bone Cement Market Segmented ?

The bone cement industry research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in 'USD million' for the period 2025-2029, as well as historical data from 2019-2023 for the following segments.

Product

  Antibiotic-loaded bone cement
  Non-antibiotic loaded bone cement


End-user

  Hospitals
  Clinics
  Ambulatory surgery centers


Type

  PMMA cement
  Calcium phosphate cement
  Glass polyalkenoate cement


Application

  Arthroplasty
  Kyphoplasty
  Vertebroplasty
  Others


Geography

  North America

    US
    Canada


  Europe

    France
    Germany
    Italy
    UK


  APAC

    China
    India
    Japan


  South America

    Brazil


  Rest of World (ROW)

By Product Insights

The antibiotic-loaded bone cement segment is estimated to witness significant growth during the forecast period.

Bone cement, a crucial component in orthopedic procedures, continues to evolve with ongoing research and development. Its handling characteristics, including compressive strength and setting time kinetics, are essential for successful implant fixation. Porosity measurement and mixing technique play a significant role in cement polymerization, influencing the rheological properties and in vivo degradation rate. The kyphoplasty technique and syringe delivery system enable precise cement injection, while hydroxyapatite cement and calcium sulfate offer advantages in bone defect repair.

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The Antibiotic-loaded bone cement segment was valued at USD 1006.90 million in 2019 and showed a gradual increase during the forecast period.

The use of antibiotic-loaded bone cement, a popular trend, enhances infection prevention and local drug delivery. The FDA approves premixed bone cement containing 0.5 g-1 g of antibiotics per 40 g of PMMA for second-stage reimplantation. This antibiotic elution property, influenced by cement porosity, improves infection treatment in complex musculoskeletal infections during joint arthroplasties and orthopedic surgeries. Biocompatibility testing, radiopaque additives, and polymerization inhibitors are other crucial factors in ensuring safe and effective surgical applications.

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Regional Analysis

North America is estimated to contribute 42% to the growth of the global market during the forecast period. Technavio's analysts have elaborately explained the regional trends and drivers that shape the market during the forecast period.

See How Bone Cement Market Demand is Rising in North America Request Free Sample

The market is witnessing significant growth, with North America holding a substantial share due to the widespread adoption of minimally invasive procedures such as joint reconstruction, fusion procedures, and fractures. The region's dominance is attributed to the high prevalence of orthopaedic disorders and the increasing number of o

The global landscape of unicorn companies, privately held startups valued at one billion U.S. dollars or more, has seen significant shifts in recent years. North America has consistently led in producing new unicorns, with a peak of *** in 2021. However, the Asia Pacific region has also been a strong contender, particularly with the rise of Chinese tech giants.

COVID-19: No. of Tests: New: Rapid Tests: Antibody: by State: Central West: Distrito Federal: Health Professional data was reported at 0.000 Unit in 30 May 2024. This stayed constant from the previous number of 0.000 Unit for 29 May 2024. COVID-19: No. of Tests: New: Rapid Tests: Antibody: by State: Central West: Distrito Federal: Health Professional data is updated daily, averaging 0.000 Unit from Jan 2020 (Median) to 30 May 2024, with 1611 observations. The data reached an all-time high of 101.000 Unit in 25 Jun 2020 and a record low of 0.000 Unit in 30 May 2024. COVID-19: No. of Tests: New: Rapid Tests: Antibody: by State: Central West: Distrito Federal: Health Professional data remains active status in CEIC and is reported by Ministry of Health. The data is categorized under Brazil Premium Database’s Health Sector – Table BR.HLA002: Disease Outbreaks: COVID-19: Number of Tests: Mild to Moderate Cases. This tests series refers to mild to moderate cases suspected of COVID-19

13538 Global import shipment records of Attache Cases with prices, volume & current Buyer's suppliers relationships based on actual Global export trade database.

World-famous coffeehouse chain, Starbucks, accounted for ****** stores worldwide in 2024. Overall, the company had over ************** more stores located internationally than in North America. These figures amounted to ****** and ******, respectively. Starbucks' global expansion The Seattle-based company’s worldwide expansion has made it one of the most successful and well-known coffeehouse chains in history. Its store count isn’t the only thing that has grown over the years, so has its revenue. Starbucks recorded its highest revenue in 2024 at over ** billion U.S. dollars. Despite the company's revenue falling to ***** billion in 2020, Starbucks' revenue surpassed pre-pandemic levels in 2021. What Starbucks products do consumers like best? The company’s central product being coffee, it comes as no surprise that the ***************** has been the number one source of revenue for Starbucks over the last decade. However, the coffeehouse chain also offers a broader range of beverages, including teas, hot chocolates, smoothies and iced drinks. Food sales also contribute to the company's overall revenue.

COVID-19: No. of Tests: New: Rapid Tests: Antigen: by State: Northeast: Bahia: Male data was reported at 0.000 Unit in 04 Jun 2024. This stayed constant from the previous number of 0.000 Unit for 03 Jun 2024. COVID-19: No. of Tests: New: Rapid Tests: Antigen: by State: Northeast: Bahia: Male data is updated daily, averaging 0.000 Unit from Jan 2020 (Median) to 04 Jun 2024, with 1617 observations. The data reached an all-time high of 1,870.000 Unit in 31 May 2021 and a record low of 0.000 Unit in 04 Jun 2024. COVID-19: No. of Tests: New: Rapid Tests: Antigen: by State: Northeast: Bahia: Male data remains active status in CEIC and is reported by Ministry of Health. The data is categorized under Brazil Premium Database’s Health Sector – Table BR.HLA002: Disease Outbreaks: COVID-19: Number of Tests: Mild to Moderate Cases. This tests series refers to mild to moderate cases suspected of COVID-19

As of June 2022, Naver Webtoon, a South Korean online service providing online comics, also called webtoons, reported a global user count of around **** million users. As the domestic webtoon industry is growing in South Korea, the online comics have also gained attraction globally. In addition to Korean content gaining popularity in general, webtoons are also more commonly adapted as a live-action series, such as the Netflix horror series "Sweet Home", "All of us are dead" or romance series such as "Cheese in the trap".

China COVID-19: Suspect Case: Imported data was reported at 0.000 Person in 07 Jan 2023. This stayed constant from the previous number of 0.000 Person for 06 Jan 2023. China COVID-19: Suspect Case: Imported data is updated daily, averaging 2.000 Person from Mar 2020 (Median) to 07 Jan 2023, with 1015 observations. The data reached an all-time high of 180.000 Person in 30 Mar 2020 and a record low of 0.000 Person in 07 Jan 2023. China COVID-19: Suspect Case: Imported data remains active status in CEIC and is reported by National Health Commission. The data is categorized under High Frequency Database’s Disease Outbreaks – Table CN.GZ: COVID-19: No of Patient.

NO: Current Health Expenditure Per Capita: Current PPP data was reported at 0.006 Intl $ mn in 2015. This records an increase from the previous number of 0.006 Intl $ mn for 2014. NO: Current Health Expenditure Per Capita: Current PPP data is updated yearly, averaging 0.005 Intl $ mn from Dec 2000 (Median) to 2015, with 16 observations. The data reached an all-time high of 0.006 Intl $ mn in 2015 and a record low of 0.003 Intl $ mn in 2000. NO: Current Health Expenditure Per Capita: Current PPP data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s Norway – Table NO.World Bank: Health Statistics. Current expenditures on health per capita expressed in international dollars at purchasing power parity (PPP).; ; World Health Organization Global Health Expenditure database (http://apps.who.int/nha/database).; Weighted Average;