ABSTRACT The considerable volume of data generated by sensors in the field presents systematic errors; thus, it is extremely important to exclude these errors to ensure mapping quality. The objective of this research was to develop and test a methodology to identify and exclude outliers in high-density spatial data sets, determine whether the developed filter process could help decrease the nugget effect and improve the spatial variability characterization of high sampling data. We created a filter composed of a global, anisotropic, and an anisotropic local analysis of data, which considered the respective neighborhood values. For that purpose, we used the median to classify a given spatial point into the data set as the main statistical parameter and took into account its neighbors within a radius. The filter was tested using raw data sets of corn yield, soil electrical conductivity (ECa), and the sensor vegetation index (SVI) in sugarcane. The results showed an improvement in accuracy of spatial variability within the data sets. The methodology reduced RMSE by 85 %, 97 %, and 79 % in corn yield, soil ECa, and SVI respectively, compared to interpolation errors of raw data sets. The filter excluded the local outliers, which considerably reduced the nugget effects, reducing estimation error of the interpolated data. The methodology proposed in this work had a better performance in removing outlier data when compared to two other methodologies from the literature.

The presence of outliers in response times can affect statistical analyses and lead to incorrect interpretation of the outcome of a study. Therefore, it is a widely accepted practice to try to minimize the effect of outliers by preprocessing the raw data. There exist numerous methods for handling outliers and researchers are free to choose among them. In this article, we use computer simulations to show that serious problems arise from this flexibility. Choosing between alternative ways for handling outliers can result in the inflation of p-values and the distortion of confidence intervals and measures of effect size. Using Bayesian parameter estimation and probability distributions with heavier tails eliminates the need to deal with response times outliers, but at the expense of opening another source of flexibility.

High-throughput sequencing is a powerful tool, but suffers biases and errors that must be accounted for to prevent false biological conclusions. Such errors include batch effects, technical errors only present in subsets of data due to procedural changes within a study. If overlooked and multiple batches of data are combined, spurious biological signals can arise, particularly if batches of data are correlated with biological variables. Batch effects can be minimized through randomisation of sample groups across batches. However, in long-term or multi-year studies where data are added incrementally, full randomisation is impossible and batch effects may be a common feature. Here we present a case study where false signals of selection were detected due to a batch effect in a multi-year study of Alpine ibex (Capra ibex). The batch effect arose because sequencing read length changed over the course of the project and populations were added incrementally to the study, resulting in non-random distributions of populations across read lengths. The differences in read length caused small misalignments in a subset of the data, leading to false variant alleles and thus false SNPs. Pronounced allele frequency differences between populations arose at these SNPs because of the correlation between read length and population. This created highly statistically significant, but biologically spurious, signals of selection and false associations between allele frequencies and the environment. We highlight the risk of batch effects and discuss strategies to reduce the impacts of batch effects in multi-year high-throughput sequencing studies.

Effect sizes calculated using mean difference for burnt-unburnt study designs and mean change for before-after desings. Outliers, as defined in the methods section of the paper, were excluded prior to calculating effect sizes.

ABSTRACT The purpose of this work is to present the Weighted Forward Search (FSW) method for the detection of outliers in asset pricing data. This new estimator, which is based on an algorithm that downweights the most anomalous observations of the dataset, is tested using both simulated and empirical asset pricing data. The impact of outliers on the estimation of asset pricing models is assessed under different scenarios, and the results are evaluated with associated statistical tests based on this new approach. Our proposal generates an alternative procedure for robust estimation of portfolio betas, allowing for the comparison between concurrent asset pricing models. The algorithm, which is both efficient and robust to outliers, is used to provide robust estimates of the models’ parameters in a comparison with traditional econometric estimation methods usually used in the literature. In particular, the precision of the alphas is highly increased when the Forward Search (FS) method is used. We use Monte Carlo simulations, and also the well-known dataset of equity factor returns provided by Prof. Kenneth French, consisting of the 25 Fama-French portfolios on the United States of America equity market using single and three-factor models, on monthly and annual basis. Our results indicate that the marginal rejection of the Fama-French three-factor model is influenced by the presence of outliers in the portfolios, when using monthly returns. In annual data, the use of robust methods increases the rejection level of null alphas in the Capital Asset Pricing Model (CAPM) and the Fama-French three-factor model, with more efficient estimates in the absence of outliers and consistent alphas when outliers are present.

Context: in recent years, cluster analysis has stimulated researchers to explore new ways to understand data behavior. The computational ease of this method and its ability to generate consistent outputs, even in small datasets, explains that to some extent. However, researchers are often mistaken in holding that clustering is a terrain in which anything goes. The literature shows the opposite: they must be careful, especially regarding the effect of outliers on cluster formation. Objective: in this tutorial paper, we contribute to this discussion by presenting four clustering techniques and their respective advantages and disadvantages in the treatment of outliers. Methods: for that, we worked from a managerial dataset and analyzed it using k-means, PAM, DBSCAN, and FCM techniques. Conclusion: we concluded that researchers need to have a more diversified repertoire of clustering techniques. After all, this would give them two relevant empirical alternatives: choose the most appropriate technique for their research objectives or adopt a multi-method approach.

211 estimates of the social cost of carbon are included in a meta-analysis. The results confirm that a lower discount rate implies a higher estimate; and that higher estimates are found in the gray literature. It is also found that there is a downward trend in the economic impact estimates of the climate; that the Stern Review’s estimates of the social cost of carbon is an outlier; and that the right tail of the distribution is fat. There is a fair chance that the annual climate liability exceeds the annual income of many people.

Analysis of the Neighborhood Parameter on Outlier Detection Algorithms - Evaluation Tests conducted for the paper: Impact of the Neighborhood Parameter on Outlier Detection Algorithms by F. Iglesias, C. Martínez, T. Zseby Context and methodology A significant number of anomaly detection algorithms base their distance and density estimates on neighborhood parameters (usually referred to as k). The experiments in this repository analyze how five different SoTA algorithms (kNN, LOF, LooP, ABOD and SDO) are affected by variations in k in combination with different alterations that the data may undergo in relation to: cardinality, dimensionality, global outlier ratio, local outlier ratio, layers of density, inliers-outliers density ratio, and zonification. Evaluations are conducted with accuracy measurements (ROC-AUC, adjusted Average Precision, and Precision at n) and runtimes. This repository is framed within the research on the following domains: algorithm evaluation, outlier detection, anomaly detection, unsupervised learning, machine learning, data mining, data analysis. Datasets and algorithms can be used for experiment replication and for further evaluation and comparison. Technical details Experiments are in Python 3 (tested with v3.9.6). Provided scripts generate all data and results. We keep them in the repo for the sake of comparability and replicability. The file and folder structure is as follows: results_datasets_scores.zip contains all results and plots as shown in the paper, also the generated datasets and files with anomaly dependencies.sh for installing required Python packages in a clean environment. generate_data.py creates experimental datasets. outdet.py runs outlier detection with ABOD, kNN, LOF, LoOP and SDO over the collection of datasets. indices.py contains functions implementing accuracy indices. explore_results.py parses results obtained with outlier detection algorithms to create comparison plots and a table with optimal ks. test_kfc.py rusn KFC tests for finding the optimal k in a collection of datasets. It requires kfc.py, which is not included in this repo and must be downloaded from https://github.com/TimeIsAFriend/KFC. kfc.py implements the KFCS and KFCR methods for finding the optimal k as presented in: [1] explore_kfc.py parses results obtained with KFCS and KFCR methods to create latex tables. README.md provides explanations and step by step instructions for replication. References [1] Jiawei Yang, Xu Tan, Sylwan Rahardja, Outlier detection: How to Select k for k-nearest-neighbors-based outlier detectors, Pattern Recognition Letters, Volume 174, 2023, Pages 112-117, ISSN 0167-8655, https://doi.org/10.1016/j.patrec.2023.08.020. License The CC-BY license applies to all data generated with the "generate_data.py" script. All distributed code is under the GNU GPL license.

AI Histology QC Outlier Detection Tool Market Outlook

According to our latest research, the global AI Histology QC Outlier Detection Tool market size reached USD 412 million in 2024, with a robust compound annual growth rate (CAGR) of 18.7% observed over the past year. The market’s expansion is primarily driven by the increasing adoption of artificial intelligence in digital pathology and the rising demand for high-precision quality control in histological workflows. By 2033, the market is forecasted to reach USD 1.97 billion, reflecting the accelerating integration of AI-powered QC outlier detection tools across clinical and research environments worldwide.

The surge in demand for AI Histology QC Outlier Detection Tools is primarily attributed to the pressing need for accuracy and consistency in histopathological diagnostics. Traditional quality control processes in histology are labor-intensive and prone to human error, which can result in diagnostic discrepancies and impact patient outcomes. The deployment of advanced AI-driven QC outlier detection tools addresses these challenges by automating the identification of anomalies and artifacts in histological slides, ensuring standardized results and significantly reducing turnaround times. Moreover, the integration of machine learning algorithms enables these systems to continuously improve their detection capabilities, further enhancing diagnostic reliability and supporting the growing trend towards digitization in pathology laboratories.

Another significant growth driver for the AI Histology QC Outlier Detection Tool market is the increasing prevalence of cancer and other chronic diseases that require histopathological examination for diagnosis and treatment planning. The rising global cancer burden, coupled with the shortage of skilled pathologists, is pushing healthcare providers to adopt AI-powered solutions that can streamline workflow efficiency and mitigate diagnostic bottlenecks. These tools not only facilitate faster and more accurate detection of outliers in tissue samples but also support pathologists in prioritizing cases that require immediate attention. As a result, healthcare institutions are investing heavily in AI-based QC solutions to optimize resource utilization, improve patient care, and comply with stringent regulatory standards for laboratory quality assurance.

Technological advancements and strategic collaborations between AI developers, pathology labs, and healthcare providers are further accelerating market growth. The ongoing development of sophisticated image analysis algorithms, cloud-based platforms, and interoperability standards is enabling seamless integration of AI QC tools into existing laboratory information systems. Additionally, government initiatives aimed at promoting digital health transformation and funding for AI research in medical diagnostics are creating a favorable environment for market expansion. The proliferation of digital pathology infrastructure, particularly in developed regions, is expected to drive the adoption of AI QC outlier detection tools, while emerging markets are witnessing growing interest as healthcare systems modernize and invest in advanced diagnostic technologies.

From a regional perspective, North America currently dominates the AI Histology QC Outlier Detection Tool market, accounting for a significant share of global revenues in 2024. The region’s leadership is underpinned by a well-established healthcare infrastructure, high adoption rates of digital pathology, and strong presence of leading AI technology providers. Europe follows closely, supported by robust investments in healthcare innovation and a proactive regulatory landscape. Meanwhile, the Asia Pacific region is poised for the fastest growth over the forecast period, driven by increasing healthcare expenditure, expanding cancer screening programs, and rising awareness of the benefits of AI-powered diagnostic solutions. Latin America and the Middle East & Africa are also expected to witness steady growth as digital transformation initiatives gain momentum in these regions.

Twitter and related social media feeds have become valuable data sources to many fields of research. Numerous researchers have thereby used social media posts for spatial analysis, since many of them contain explicit geographic locations. However, despite its widespread use within applied research, a thorough understanding of the underlying spatial characteristics of these data is still lacking. In this paper, we investigate how topological outliers influence the outcomes of spatial analyses of social media data. These outliers appear when different users contribute heterogeneous information about different phenomena simultaneously from similar locations. As a consequence, various messages representing different spatial phenomena are captured closely to each other, and are at risk to be falsely related in a spatial analysis. Our results reveal indications for corresponding spurious effects when analyzing Twitter data. Further, we show how the outliers distort the range of outcomes of spatial analysis methods. This has significant influence on the power of spatial inferential techniques, and, more generally, on the validity and interpretability of spatial analysis results. We further investigate how the issues caused by topological outliers are composed in detail. We unveil that multiple disturbing effects are acting simultaneously and that these are related to the geographic scales of the involved overlapping patterns. Our results show that at some scale configurations, the disturbances added through overlap are more severe than at others. Further, their behavior turns into a volatile and almost chaotic fluctuation when the scales of the involved patterns become too different. Overall, our results highlight the critical importance of thoroughly considering the specific characteristics of social media data when analyzing them spatially.

In the present era of large-scale surveys, big data present new challenges to the discovery process for anomalous data. Such data can be indicative of systematic errors, extreme (or rare) forms of known phenomena, or most interestingly, truly novel phenomena that exhibit as-of-yet unobserved behaviours. In this work, we present an outlier scoring methodology to identify and characterize the most promising unusual sources to facilitate discoveries of such anomalous data. We have developed a data mining method based on k-nearest neighbour distance in feature space to efficiently identify the most anomalous light curves. We test variations of this method including using principal components of the feature space, removing select features, the effect of the choice of k, and scoring to subset samples. We evaluate the performance of our scoring on known object classes and find that our scoring consistently scores rare (<1000) object classes higher than common classes. We have applied scoring to all long cadence light curves of Quarters 1-17 of Kepler's prime mission and present outlier scores for all 2.8 million light curves for the roughly 200k objects.

31OutlierSequencesBED file for genomic placement of mapped reads from selection experiment42seqsOf49SNPs_ForMappingToGenomeShared outlier sequences from selected lines.FloridaPopMap of Florida Populations "Wild Derived"FloridaPopFlorida population genetics file (.ped)P-val-for -LD_49LociRevisedRevisedP-values for pairwise exact tests.SelectedvsWild-expermt.map file for population genomic comparisons of the wild derived mosquitoes.SelectedvsWild-expermt.ped file for comparisons of population genomics for field populations from FloridaYvsNOutlierLoci.bed file for the outlier loci comparing "yes" and "no" phenotypes from wild-derived populations in Florida.

Genetics-based approaches have informed fisheries management for decades, yet remain challenging to implement within systems involving recently diverged stocks or where gene flow persists. In such cases, genetic markers exhibiting locus-specific (“outlier†) effects associated with divergent selection may provide promising alternatives to loci that reflect genome-wide (“neutral†) effects for guiding fisheries management. Okanagan Lake kokanee (Oncorhynchus nerka), a fishery of conservation concern, exhibits two sympatric ecotypes adapted to different reproductive environments, however, previous research demonstrated the limited utility of neutral microsatellites for assigning individuals. Here, we investigated the efficacy of an outlier-based approach to fisheries management by screening >11,000 expressed sequence tags for linked microsatellites and conducting genomic scans for kokanee sampled across seven spawning sites. We identified eight outliers among 52 polymorphic loci that det...

The Controlled Anomalies Time Series (CATS) Dataset consists of commands, external stimuli, and telemetry readings of a simulated complex dynamical system with 200 injected anomalies.

The CATS Dataset exhibits a set of desirable properties that make it very suitable for benchmarking Anomaly Detection Algorithms in Multivariate Time Series [1]:

• Multivariate (17 variables) including sensors reading and control signals. It simulates the operational behaviour of an arbitrary complex system including:
  • 4 Deliberate Actuations / Control Commands sent by a simulated operator / controller, for instance, commands of an operator to turn ON/OFF some equipment.
  • 3 Environmental Stimuli / External Forces acting on the system and affecting its behaviour, for instance, the wind affecting the orientation of a large ground antenna.
  • 10 Telemetry Readings representing the observable states of the complex system by means of sensors, for instance, a position, a temperature, a pressure, a voltage, current, humidity, velocity, acceleration, etc.
• 5 million timestamps. Sensors readings are at 1Hz sampling frequency.
  • 1 million nominal observations (the first 1 million datapoints). This is suitable to start learning the "normal" behaviour.
  • 4 million observations that include both nominal and anomalous segments. This is suitable to evaluate both semi-supervised approaches (novelty detection) as well as unsupervised approaches (outlier detection).
• 200 anomalous segments. One anomalous segment may contain several successive anomalous observations / timestamps. Only the last 4 million observations contain anomalous segments.
• Different types of anomalies to understand what anomaly types can be detected by different approaches.
• Fine control over ground truth. As this is a simulated system with deliberate anomaly injection, the start and end time of the anomalous behaviour is known very precisely. In contrast to real world datasets, there is no risk that the ground truth contains mislabelled segments which is often the case for real data.
• Obvious anomalies. The simulated anomalies have been designed to be "easy" to be detected for human eyes (i.e., there are very large spikes or oscillations), hence also detectable for most algorithms. It makes this synthetic dataset useful for screening tasks (i.e., to eliminate algorithms that are not capable to detect those obvious anomalies). However, during our initial experiments, the dataset turned out to be challenging enough even for state-of-the-art anomaly detection approaches, making it suitable also for regular benchmark studies.
• Context provided. Some variables can only be considered anomalous in relation to other behaviours. A typical example consists of a light and switch pair. The light being either on or off is nominal, the same goes for the switch, but having the switch on and the light off shall be considered anomalous. In the CATS dataset, users can choose (or not) to use the available context, and external stimuli, to test the usefulness of the context for detecting anomalies in this simulation.
• Pure signal ideal for robustness-to-noise analysis. The simulated signals are provided without noise: while this may seem unrealistic at first, it is an advantage since users of the dataset can decide to add on top of the provided series any type of noise and choose an amplitude. This makes it well suited to test how sensitive and robust detection algorithms are against various levels of noise.
• No missing data. You can drop whatever data you want to assess the impact of missing values on your detector with respect to a clean baseline.

[1] Example Benchmark of Anomaly Detection in Time Series: “Sebastian Schmidl, Phillip Wenig, and Thorsten Papenbrock. Anomaly Detection in Time Series: A Comprehensive Evaluation. PVLDB, 15(9): 1779 - 1797, 2022. doi:10.14778/3538598.3538602”

About Solenix

Solenix is an international company providing software engineering, consulting services and software products for the space market. Solenix is a dynamic company that brings innovative technologies and concepts to the aerospace market, keeping up to date with technical advancements and actively promoting spin-in and spin-out technology activities. We combine modern solutions which complement conventional practices. We aspire to achieve maximum customer satisfaction by fostering collaboration, constructivism, and flexibility.

Here are six files that provide details for all 44,120 identified single nucleotide polymorphisms (SNPs) or the 215 outlier SNPs associated with the evolution of rapid character displacement among replicate islands with (2Spp) and without competition (1Spp) between two Anolis species. On 2Spp islands, A. carolinensis occurs higher in trees and have evolved larger toe pads. Among 1Spp and 2Spp island populations, we identify 44,120 SNPs, with 215-outlier SNPs with improbably large FST values, low nucleotide variation, greater linkage than expected, and these SNPs are enriched for animal walking behavior. Thus, we conclude that these 215-outliers are evolving by natural selection in response to the phenotypic convergent evolution of character displacement. There are two, non-mutually exclusive perspective of these nucleotide variants. One is character displacement is convergent: all 215 outlier SNPs are shared among 3 out of 5 2Spp island and 24% of outlier SNPS are shared among all five out of five 2Spp island. Second, character displacement is genetically redundant because the allele frequencies in one or more 2Spp are similar to 1Spp islands: among one or more 2Spp islands 33% of outlier SNPS are within the range of 1Spp MiAF and 76% of outliers are more similar to 1Spp island than mean MiAF of 2Spp islands. Focusing on convergence SNP is scientifically more robust, yet it distracts from the perspective of multiple genetic solutions that enhances the rate and stability of adaptive change. The six files include: a description of eight islands, details of 94 individuals, and four files on SNPs. The four SNP files include the VCF files for 94 individuals with 44KSNPs and two files (Excel sheet/tab-delimited file) with FST, p-values and outlier status for all 44,120 identified single nucleotide polymorphisms (SNPs) associated with the evolution of rapid character displacement. The sixth file is a detailed file on the 215 outlier SNPs. Complete sequence data is available at Bioproject PRJNA833453, which including samples not included in this study. The 94 individuals used in this study are described in “Supplemental_Sample_description.txt” Methods Anoles and genomic DNA: Tissue or DNA for 160 Anolis carolinensis and 20 A. sagrei samples were provided by the Museum of Comparative Zoology at Harvard University (Table S2). Samples were previously used to examine evolution of character displacement in native A. carolinensis following invasion by A. sagrei onto man-made spoil islands in Mosquito Lagoon Florida (Stuart et al. 2014). One hundred samples were genomic DNAs, and 80 samples were tissues (terminal tail clip, Table S2). Genomic DNA was isolated from 80 of 160 A. carolinensis individuals (MCZ, Table S2) using a custom SPRI magnetic bead protocol (Psifidi et al. 2015). Briefly, after removing ethanol, tissues were placed in 200 ul of GH buffer (25 mM Tris- HCl pH 7.5, 25 mM EDTA, , 2M GuHCl Guanidine hydrochloride, G3272 SIGMA, 5 mM CaCl2, 0.5% v/v Triton X-100, 1% N-Lauroyl-Sarcosine) with 5% per volume of 20 mg/ml proteinase K (10 ul/200 ul GH) and digested at 55º C for at least 2 hours. After proteinase K digestion, 100 ul of 0.1% carboxyl-modified Sera-Mag Magnetic beads (Fisher Scientific) resuspended in 2.5 M NaCl, 20% PEG were added and allowed to bind the DNA. Beads were subsequently magnetized and washed twice with 200 ul 70% EtOH, and then DNA was eluted in 100 ul 0.1x TE (10 mM Tris, 0.1 mM EDTA). All DNA samples were gel electrophoresed to ensure high molecular mass and quantified by spectrophotometry and fluorescence using Biotium AccuBlueTM High Sensitivity dsDNA Quantitative Solution according to manufacturer’s instructions. Genotyping-by-sequencing (GBS) libraries were prepared using a modified protocol after Elshire et al. (Elshire et al. 2011). Briefly, high-molecular-weight genomic DNA was aliquoted and digested using ApeKI restriction enzyme. Digests from each individual sample were uniquely barcoded, pooled, and size selected to yield insert sizes between 300-700 bp (Borgstrom et al. 2011). Pooled libraries were PCR amplified (15 cycles) using custom primers that extend into the genomic DNA insert by 3 bases (CTG). Adding 3 extra base pairs systematically reduces the number of sequenced GBS tags, ensuring sufficient sequencing depth. The final library had a mean size of 424 bp ranging from 188 to 700 bp . Anolis SNPs: Pooled libraries were sequenced on one lane on the Illumina HiSeq 4000 in 2x150 bp paired-end configuration, yielding approximately 459 million paired-end reads ( ~138 Gb). The medium Q-Score was 42 with the lower 10% Q-Scores exceeding 32 for all 150 bp. The initial library contained 180 individuals with 8,561,493 polymorphic sites. Twenty individuals were Anolis sagrei, and two individuals (Yan 1610 & Yin 1411) clustered with A. sagrei and were not used to define A. carolinesis’ SNPs. Anolis carolinesis reads were aligned to the Anolis carolinensis genome (NCBI RefSeq accession number:/GCF_000090745.1_AnoCar2.0). Single nucleotide polymorphisms (SNPs) for A. carolinensis were called using the GBeaSy analysis pipeline (Wickland et al. 2017) with the following filter settings: minimum read length of 100 bp after barcode and adapter trimming, minimum phred-scaled variant quality of 30 and minimum read depth of 5. SNPs were further filtered by requiring SNPs to occur in > 50% of individuals, and 66 individuals were removed because they had less than 70% of called SNPs. These filtering steps resulted in 51,155 SNPs among 94 individuals. Final filtering among 94 individuals required all sites to be polymorphic (with fewer individuals, some sites were no longer polymorphic) with a maximum of 2 alleles (all are bi-allelic), minimal allele frequency 0.05, and He that does not exceed HWE (FDR <0.01). SNPs with large He were removed (2,280 SNPs). These SNPs with large significant heterozygosity may result from aligning paralogues (different loci), and thus may not represent polymorphisms. No SNPs were removed with low He (due to possible demography or other exceptions to HWE). After filtering, 94 individual yielded 44,120 SNPs. Thus, the final filtered SNP data set was 44K SNPs from 94 indiviuals. Statistical Analyses: Eight A. carolinensis populations were analyzed: three populations from islands with native species only (1Spp islands) and 5 populations from islands where A. carolinesis co-exist with A. sagrei (2Spp islands, Table 1, Table S1). Most analyses pooled the three 1Spp islands and contrasted these with the pooled five 2Spp islands. Two approaches were used to define SNPs with unusually large allele frequency differences between 1Spp and 2Spp islands: 1) comparison of FST values to random permutations and 2) a modified FDIST approach to identify outlier SNPs with large and statistically unlikely FST values. Random Permutations: FST values were calculated in VCFTools (version 4.2, (Danecek et al. 2011)) where the p-value per SNP were defined by comparing FST values to 1,000 random permutations using a custom script (below). Basically, individuals and all their SNPs were randomly assigned to one of eight islands or to 1Spp versus 2Spp groups. The sample sizes (55 for 2Spp and 39 for 1Spp islands) were maintained. FST values were re-calculated for each 1,000 randomizations using VCFTools. Modified FDIST: To identify outlier SNPs with statistically large FST values, a modified FDIST (Beaumont and Nichols 1996) was implemented in Arlequin (Excoffier et al. 2005). This modified approach applies 50,000 coalescent simulations using hierarchical population structure, in which demes are arranged into k groups of d demes and in which migration rates between demes are different within and between groups. Unlike the finite island models, which have led to large frequencies of false positive because populations share different histories (Lotterhos and Whitlock 2014), the hierarchical island model avoids these false positives by avoiding the assumption of similar ancestry (Excoffier et al. 2009). References Beaumont, M. A. and R. A. Nichols. 1996. Evaluating loci for use in the genetic analysis of population structure. P Roy Soc B-Biol Sci 263:1619-1626. Borgstrom, E., S. Lundin, and J. Lundeberg. 2011. Large scale library generation for high throughput sequencing. PLoS One 6:e19119. Bradbury, P. J., Z. Zhang, D. E. Kroon, T. M. Casstevens, Y. Ramdoss, and E. S. Buckler. 2007. TASSEL: software for association mapping of complex traits in diverse samples. Bioinformatics 23:2633-2635. Cingolani, P., A. Platts, L. Wang le, M. Coon, T. Nguyen, L. Wang, S. J. Land, X. Lu, and D. M. Ruden. 2012. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) 6:80-92. Danecek, P., A. Auton, G. Abecasis, C. A. Albers, E. Banks, M. A. DePristo, R. E. Handsaker, G. Lunter, G. T. Marth, S. T. Sherry, G. McVean, R. Durbin, and G. Genomes Project Analysis. 2011. The variant call format and VCFtools. Bioinformatics 27:2156-2158. Earl, D. A. and B. M. vonHoldt. 2011. Structure Harvester: a website and program for visualizing STRUCTURE output and implementing the Evanno method. Conservation Genet Resour 4:359-361. Elshire, R. J., J. C. Glaubitz, Q. Sun, J. A. Poland, K. Kawamoto, E. S. Buckler, and S. E. Mitchell. 2011. A robust, simple genotyping-by-sequencing (GBS) approach for high diversity species. PLoS One 6:e19379. Evanno, G., S. Regnaut, and J. Goudet. 2005. Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. Mol Ecol 14:2611-2620. Excoffier, L., T. Hofer, and M. Foll. 2009. Detecting loci under selection in a hierarchically structured population. Heredity 103:285-298. Excoffier, L., G. Laval, and S. Schneider. 2005. Arlequin (version 3.0): An integrated software package for population genetics data analysis.

Physical fitness is a key element of a healthy life, and being overweight or lacking physical exercise will lead to health problems. Therefore, assessing an individual’s physical health status from a non-medical, cost-effective perspective is essential. This paper aimed to evaluate the national physical health status through national physical examination data, selecting 12 indicators to divide the physical health status into four levels: excellent, good, pass, and fail. The existing challenge lies in the fact that most literature on physical fitness assessment mainly focuses on the two major groups of sports athletes and school students. Unfortunately, there is no reasonable index system has been constructed. The evaluation method has limitations and cannot be applied to other groups. This paper builds a reasonable health indicator system based on national physical examination data, breaks group restrictions, studies national groups, and hopes to use machine learning models to provide helpful health suggestions for citizens to measure their physical status. We analyzed the significance of the selected indicators through nonparametric tests and exploratory statistical analysis. We used seven machine learning models to obtain the best multi-classification model for the physical fitness test level. Comprehensive research showed that MLP has the best classification effect, with macro-precision reaching 74.4% and micro-precision reaching 72.8%. Furthermore, the recall rates are also above 70%, and the Hamming loss is the smallest, i.e., 0.272. The practical implications of these findings are significant. Individuals can use the classification model to understand their physical fitness level and status, exercise appropriately according to the measurement indicators, and adjust their lifestyle, which is an important aspect of health management.

This dataset contains a list of outlier sample concentrations identified for 17 water quality constituents from streamwater sample collected at 15 study watersheds in Gwinnett County, Georgia for water years 2003 to 2020. The 17 water quality constituents are: biochemical oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS), suspended sediment concentration (SSC), total nitrogen (TN), total nitrate plus nitrite (NO3NO2), total ammonia plus organic nitrogen (TKN), dissolved ammonia (NH3), total phosphorus (TP), dissolved phosphorus (DP), total organic carbon (TOC), total calcium (Ca), total magnesium (Mg), total copper (TCu), total lead (TPb), total zinc (TZn), and total dissolved solids (TDS). 885 outlier concentrations were identified. Outliers were excluded from model calibration datasets used to estimate streamwater constituent loads for 12 of these constituents. Outlier concentrations were removed because they had a high influence on the model fits of the concentration relations, which could substantially affect model predictions. Identified outliers were also excluded from loads that were calculated using the Beale ratio estimator. Notes on reason(s) for considering a concentration as an outlier are included.

With the forecast increase in air traffic demand over the next decades, it is imperative to develop tools to provide traffic flow managers with the information required to support decision making. In particular, decision-support tools for traffic flow management should aid in limiting controller workload and complexity, while supporting increases in air traffic throughput. While many decision-support tools exist for short-term traffic planning, few have addressed the strategic needs for medium- and long-term planning for time horizons greater than 30 minutes. This paper seeks to address this gap through the introduction of 3D aircraft proximity maps that evaluate the future probability of presence of at least one or two aircraft at any given point of the airspace. Three types of proximity maps are presented: presence maps that indicate the local density of traffic; conflict maps that determine locations and probabilities of potential conflicts; and outliers maps that evaluate the probability of conflict due to aircraft not belonging to dominant traffic patterns. These maps provide traffic flow managers with information relating to the complexity and difficulty of managing an airspace. The intended purpose of the maps is to anticipate how aircraft flows will interact, and how outliers impact the dominant traffic flow for a given time period. This formulation is able to predict which "critical" regions may be subject to conflicts between aircraft, thereby requiring careful monitoring. These probabilities are computed using a generative aircraft flow model. Time-varying flow characteristics, such as geometrical configuration, speed, and probability density function of aircraft spatial distribution within the flow, are determined from archived Enhanced Traffic Management System data, using a tailored clustering algorithm. Aircraft not belonging to flows are identified as outliers.

Adult-onset progressive hearing loss is a common, complex disease with a strong genetic component. Although to date over 150 genes have been identified as contributing to human hearing loss, many more remain to be discovered, as does most of the underlying genetic diversity. Many different variants have been found to underlie adult-onset hearing loss, but they tend to be rare variants with a high impact upon the gene product. It is likely that combinations of more common, lower impact variants also play a role in the prevalence of the disease. Here we present our exome study of hearing loss in a cohort of 532 older adult volunteers with extensive phenotypic data, including 99 older adults with normal hearing, an important control set. Firstly, we carried out an outlier analysis to identify genes with a high variant load in older adults with hearing loss compared to those with normal hearing. Secondly, we used audiometric threshold data to identify individual variants which appear to contribute to different threshold values. We followed up these analyses in a second cohort. Using these approaches, we identified genes and variants linked to better hearing as well as those linked to worse hearing. These analyses identified some known deafness genes, demonstrating proof of principle of our approach. However, most of the candidate genes are novel associations with hearing loss. While the results support the suggestion that genes responsible for severe deafness may also be involved in milder hearing loss, they also suggest that there are many more genes involved in hearing which remain to be identified. Our candidate gene lists may provide useful starting points for improved diagnosis and drug development.

Outliers can be more problematic in longitudinal data than in independent observations due to the correlated nature of such data. It is common practice to discard outliers as they are typically regarded as a nuisance or an aberration in the data. However, outliers can also convey meaningful information concerning potential model misspecification, and ways to modify and improve the model. Moreover, outliers that occur among the latent variables (innovative outliers) have distinct characteristics compared to those impacting the observed variables (additive outliers), and are best evaluated with different test statistics and detection procedures. We demonstrate and evaluate the performance of an outlier detection approach for multi-subject state-space models in a Monte Carlo simulation study, with corresponding adaptations to improve power and reduce false detection rates. Furthermore, we demonstrate the empirical utility of the proposed approach using data from an ecological momentary assessment study of emotion regulation together with an open-source software implementation of the procedures.