Rising global food insecurity driven by population growth needs urgent measure for universal access to food. This research employs Comparative Performance Analysis (CPA) to evaluate the Global Food Security Index (GFSI), its components [Affordability (AF), Availability (AV), Quality & Safety (Q&S) and Sustainability & Adaptation (S&A)] in tandem with Annual Population Change (APC) for world’s five most populous countries (India, China, USA, Indonesia and Pakistan) using dataset spanning from 2012 to 2022. CPA is applied using descriptive analysis, correlation analysis, Rule of Thumb (RoT) and testing of hypothesis etc. RoT is used with a new analytical approach by applying the significance measures for correlation coefficients. The study suggests that India should enhance its GFSI rank by addressing AF and mitigating the adverse effects of APC on GFSI with a particular focus on Q&S and S&A. China needs to reduce the impact of APC on GFSI by prioritizing AV and S&A. The USA is managing its GFSI well, but focused efforts are still required to reduce APC’s impact on Q&S and S&A. Indonesia should improve across all sectors with a particular focus on APC reduction and mitigating its adverse effects on AF, AV, and S&A. Pakistan should intensify efforts to boost its rank and enhance all sectors with reducing APC. There is statistically significant and negative relation between GFSI and APC for China, Indonesia and found insignificant for others countries. This study holds promise for providing crucial policy recommendations to enhance food security by tackling its underlying factors.