Coronavirus disease 2019 (COVID-19) has already raised serious concern globally as the number of confirmed or suspected cases have increased rapidly. Epidemiological studies reported that obesity is associated with a higher rate of mortality in patients with COVID-19. Yet, to our knowledge, there is no comprehensive systematic review and meta-analysis to assess the effects of obesity and mortality among patients with COVID-19. We, therefore, aimed to evaluate the effect of obesity, associated comorbidities, and other factors on the risk of death due to COVID-19. We did a systematic search on PubMed, EMBASE, Google Scholar, Web of Science, and Scopus between January 1, 2020, and August 30, 2020. We followed Cochrane Guidelines to find relevant articles, and two reviewers extracted data from retrieved articles. Disagreement during those stages was resolved by discussion with the main investigator. The random-effects model was used to calculate effect sizes. We included 17 articles with a total of 543,399 patients. Obesity was significantly associated with an increased risk of mortality among patients with COVID-19 (RRadjust: 1.42 (95%CI: 1.24–1.63, p < 0.001). The pooled risk ratio for class I, class II, and class III obesity were 1.27 (95%CI: 1.05–1.54, p = 0.01), 1.56 (95%CI: 1.11–2.19, p < 0.01), and 1.92 (95%CI: 1.50–2.47, p < 0.001), respectively). In subgroup analysis, the pooled risk ratio for the patients with stroke, CPOD, CKD, and diabetes were 1.80 (95%CI: 0.89–3.64, p = 0.10), 1.57 (95%CI: 1.57–1.91, p < 0.001), 1.34 (95%CI: 1.18–1.52, p < 0.001), and 1.19 (1.07–1.32, p = 0.001), respectively. However, patients with obesity who were more than 65 years had a higher risk of mortality (RR: 2.54; 95%CI: 1.62–3.67, p < 0.001). Our study showed that obesity was associated with an increased risk of death from COVID-19, particularly in patients aged more than 65 years. Physicians should aware of these risk factors when dealing with patients with COVID-19 and take early treatment intervention to reduce the mortality of COVID-19 patients.

Accountability for global health issues such as a pandemic and its devastating consequences are usually ascribed to a virus, but a comprehensive view should also take into account the state of the host. Data suggests that excessive nutrition is to blame for a yet unknown but not negligible portion of deaths attributed to severe acute respiratory syndrome coronavirus 2. We analyzed the correlation between mean body mass index (BMI) and 2-year coronavirus disease 2019 (COVID-19) mortality rates reported by 181 countries worldwide. Almost two thirds of the countries included had a mean BMI greater or equal to 25, with death rates ranging from 3 to 6,280 per million. Death rates in countries with a mean BMI below 25 ranged from 3 to 1,533. When the analysis was restricted to countries where the extent of testing was deemed more representative of actual mortality, only 20.1% had a mean BMI

Context

Dataset aims to facilitate a state by state comparison of potential risk factors that may heighten Covid 19 transmission rates or deaths. It includes state by state estimates of: covid 19 positives/deaths, flu/pneumonia deaths, major city population densities, available hospital resources, high risk health condition prevalance, population over 60, means of work transportation rates, housing characteristics (ie number of large apartment complexes/seniors living alone), and industry information.

Content

The Data Includes:

1) Covid 19 Outcome Stats:

Covid_Death : Covid Deaths by State

Covid_Positive : Covid Positive Tests by State

2) US Major City Population Density by State: CBSA_Major_City_max_weighted_density

3) KFF Estimates of Total Hospital Beds by State:

Kaiser_Total_Hospital_Beds

4) 2018 Season Flu and Pneumonia Death Stats:

FLUVIEW_TOTAL_PNEUMONIA_DEATHS_Season_2018

FLUVIEW_TOTAL_INFLUENZA_DEATHS_Season_2018

5)US Total Rates of Flu Hospitalization by Underlying Condition:

Fluview_US_FLU_Hospitalization_Rate_....

6) State by State BRFSS Prevalance Rates of Conditions Associated with Higher Flu Hospitalization Rates

BRFSS_Diabetes_Prevalance BRFSS_Asthma_Prevalance BRFSS_COPD_Prevalance
BRFSS_Obesity BMI Prevalance BRFSS_Other_Cancer_Prevalance BRFSS_Kidney_Disease_Prevalance BRFSS_Obesity BMI Prevalance BRFSS_2017_High_Cholestoral_Prevalance BRFSS_2017_High_Blood_Pressure_Prevalance Census_Population_Over_60

7)State by state breakdown of Means of Work Transpotation:

COMMUTE_Census_Worker_Public_Transportation_Rate

8) State by state breakdown of Housing Characteristics

9) State by State breakdown of Industry Information

Acknowledgements

Links to data sources:

https://worldpopulationreview.com/states/

https://covidtracking.com/data/

https://gis.cdc.gov/GRASP/Fluview/FluHospRates.html https://www.kff.org/health-costs/issue-brief/state-data-and-policy-actions-to-address-coronavirus/#stateleveldata

https://data.census.gov/cedsci/table?q=United%20States&tid=ACSDP1Y2018.DP05&hidePreview=true&vintage=2018&layer=VT_2018_040_00_PY_D1&cid=S0103_C01_001E

Census Tables: ACSST1Y2018.S1811 ACSST1Y2018.S0102 ACSST1Y2018.S2403 ACSST1Y2018.S2501 ACSST1Y2018.S2504

https://www.census.gov/library/visualizations/2012/dec/c2010sr-01-density.html

https://gis.cdc.gov/grasp/fluview/mortality.html

Inspiration

I hope to show the existence of correlations that warrant a deeper county by county analysis to identify areas of increased risk requiring increased resource allocation or increased attention to preventative measures.

Context

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. Most people infected with COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness. During the entire course of the pandemic, one of the main problems that healthcare providers have faced is the shortage of medical resources and a proper plan to efficiently distribute them. In these tough times, being able to predict what kind of resource an individual might require at the time of being tested positive or even before that will be of immense help to the authorities as they would be able to procure and arrange for the resources necessary to save the life of that patient.

The main goal of this project is to build a machine learning model that, given a Covid-19 patient's current symptom, status, and medical history, will predict whether the patient is in high risk or not.

content

The dataset was provided by the Mexican government (link). This dataset contains an enormous number of anonymized patient-related information including pre-conditions. The raw dataset consists of 21 unique features and 1,048,576 unique patients. In the Boolean features, 1 means "yes" and 2 means "no". values as 97 and 99 are missing data.

• sex: 1 for female and 2 for male.
• age: of the patient.
• classification: covid test findings. Values 1-3 mean that the patient was diagnosed with covid in different degrees. 4 or higher means that the patient is not a carrier of covid or that the test is inconclusive.
• patient type: type of care the patient received in the unit. 1 for returned home and 2 for hospitalization.
• pneumonia: whether the patient already have air sacs inflammation or not.
• pregnancy: whether the patient is pregnant or not.
• diabetes: whether the patient has diabetes or not.
• copd: Indicates whether the patient has Chronic obstructive pulmonary disease or not.
• asthma: whether the patient has asthma or not.
• inmsupr: whether the patient is immunosuppressed or not.
• hypertension: whether the patient has hypertension or not.
• cardiovascular: whether the patient has heart or blood vessels related disease.
• renal chronic: whether the patient has chronic renal disease or not.
• other disease: whether the patient has other disease or not.
• obesity: whether the patient is obese or not.
• tobacco: whether the patient is a tobacco user.
• usmr: Indicates whether the patient treated medical units of the first, second or third level.
• medical unit: type of institution of the National Health System that provided the care.
• intubed: whether the patient was connected to the ventilator.
• icu: Indicates whether the patient had been admitted to an Intensive Care Unit.
• date died: If the patient died indicate the date of death, and 9999-99-99 otherwise.

Additional inpatient cases/hospitalizations, ICU admissions and deaths (per 10,000 total population in country and as percentage of total COVID-19 outcomes) related to overweight and obesity in 2020 and 2021.

Heart conditions were the most common causes of death in Mexico in 2023. During that period, more than ******* people died in the North American country as a result from said conditions. Diabetes mellitus ranked second, with over ******* deaths registered that year. Obesity in MexicoObesity and being overweight can worsen many risk factors for developing heart conditions, prediabetes, type 2 diabetes, and gestational diabetes, which in the case of a COVID-19 infection can lead to a severe course of the disease. In 2020, Mexico was reported as having one of the largest overweight and/or obese population in Latin America, with ** percent of people in the country having a body mass index higher than 25. In 2022, obesity was announced as being one of the most common illnesses experienced in Mexico, with over ******* cases estimated. In a decade from now, it is predicted that about *** million children in Mexico will suffer from obesity. If estimations are correct, this North American country will belong to the world’s top 10 countries with the most obese children in 2030. Physical activity in MexicoIt is not only a matter of food intake. A 2023 survey found, for instance, that only **** percent of Mexican population practiced sports and physical activities in their free time, a figure that has decreased in comparison to 2013. Less than ** percent of the physically active Mexicans practice sports for fun. However, the vast majority were motivated by health reasons.

Background: Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) Delta variant (B.1.617.2) has been responsible for the current increase in Coronavirus disease 2019 (COVID-19) infectivity rate worldwide. We compared the impact of the Delta variant and non-Delta variant on the COVID-19 outcomes in patients from Yogyakarta and Central Java provinces, Indonesia.Methods: In this cross-sectional study, we ascertained 161 patients, 69 with the Delta variant and 92 with the non-Delta variant. The Illumina MiSeq next-generation sequencer was used to perform the whole-genome sequences of SARS-CoV-2.Results: The mean age of patients with the Delta variant and the non-Delta variant was 27.3 ± 20.0 and 43.0 ± 20.9 (p = 3 × 10−6). The patients with Delta variant consisted of 23 males and 46 females, while the patients with the non-Delta variant involved 56 males and 36 females (p = 0.001). The Ct value of the Delta variant (18.4 ± 2.9) was significantly lower than that of the non-Delta variant (19.5 ± 3.8) (p = 0.043). There was no significant difference in the hospitalization and mortality of patients with Delta and non-Delta variants (p = 0.80 and 0.29, respectively). None of the prognostic factors were associated with the hospitalization, except diabetes with an OR of 3.6 (95% CI = 1.02–12.5; p = 0.036). Moreover, the patients with the following factors have been associated with higher mortality rate than the patients without the factors: age ≥65 years, obesity, diabetes, hypertension, and cardiovascular disease with the OR of 11 (95% CI = 3.4–36; p = 8 × 10−5), 27 (95% CI = 6.1–118; p = 1 × 10−5), 15.6 (95% CI = 5.3–46; p = 6 × 10−7), 12 (95% CI = 4–35.3; p = 1.2 × 10−5), and 6.8 (95% CI = 2.1–22.1; p = 0.003), respectively. Multivariate analysis showed that age ≥65 years, obesity, diabetes, and hypertension were the strong prognostic factors for the mortality of COVID-19 patients with the OR of 3.6 (95% CI = 0.58–21.9; p = 0.028), 16.6 (95% CI = 2.5–107.1; p = 0.003), 5.5 (95% CI = 1.3–23.7; p = 0.021), and 5.8 (95% CI = 1.02–32.8; p = 0.047), respectively.Conclusions: We show that the patients infected by the SARS-CoV-2 Delta variant have a lower Ct value than the patients infected by the non-Delta variant, implying that the Delta variant has a higher viral load, which might cause a more transmissible virus among humans. However, the Delta variant does not affect the COVID-19 outcomes in our patients. Our study also confirms that older age and comorbidity increase the mortality rate of patients with COVID-19.

A survey of people from 30 different countries around the world found that mental health was the biggest health problem respondents said was facing their country in 2025. Other health problems reported by respondents included cancer, stress, and obesity. The COVID-19 pandemic The COVID-19 pandemic impacted almost every country in the world and was the biggest global health crisis in recent history. It resulted in hundreds of millions of cases and millions of deaths, causing unprecedented disruption in health care systems. Lockdowns imposed in many countries to halt the spread of the virus also resulted in a rise of mental health issues as feelings of stress, isolation, and hopelessness arose. However, vaccines to combat the virus were developed at record speed, and many countries have now vaccinated large shares of their population. Nevertheless, in 2025, *** percent of respondents still stated that COVID-19 was the biggest health problem facing their country. Mental health issues One side effect of the COVID-19 pandemic has been a focus on mental health around the world. The two most common mental health issues worldwide are anxiety disorders and depression. In 2021, it was estimated that around *** percent of the global population had an anxiety disorder, while **** percent suffered from depression. Rates of depression are higher among females than males, with some *** percent of females suffering from depression, compared to *** percent of men. However, rates of suicide in most countries are higher among men than women. One positive outcome of the COVID-19 pandemic and the spotlight it shined on mental health may be a decrease in stigma surrounding mental health issues and seeking help for such issues. This would be a positive development, as many people around the world do not or cannot receive the necessary treatment they need for their mental health.

Readmission within 180-days of discharge.

The leading causes of death in the United States are heart disease and cancer. However, in 2022, COVID-19 was the fourth leading cause of death in the United States, accounting for around six percent of all deaths that year. In 2022, there were around 45 deaths from COVID-19 per 100,000 population.

Cardiovascular disease

Deaths from cardiovascular disease are more common among men than women but have decreased for both sexes over the past few decades. Coronary heart disease accounts for the highest portion of cardiovascular disease deaths in the United States, followed by stroke and high blood pressure. The states with the highest death rates from cardiovascular disease include Oklahoma, Mississippi, and Alabama. Smoking tobacco, physical inactivity, poor diet, stress, and being overweight or obese are all risk factors for developing heart disease.

Cancer

Although cancer is the second leading cause of death in the United States, like deaths from cardiovascular disease, deaths from cancer have decreased over the last few decades. The highest death rates from cancer come from lung cancer for both men and women. Breast cancer is the second deadliest cancer for women, while prostate cancer is the second deadliest cancer for men. West Virginia, Mississippi, and Kentucky lead the nation with the highest cancer death rates.

In the United States, the average person has a * in * chance of dying from heart disease and a * in * chance of dying from cancer. In comparison, the odds of dying from a dog attack are * in ******. Sadly, the odds of dying from an opioid overdose in the U.S. are * in **, making death from an opioid overdose more likely than dying from a motor vehicle accident. Opioid overdose death rates have increased insignificantly in the U.S. over the past decade. Leading causes of death in the United States Given the high lifetime odds of dying from heart disease or cancer, it is unsurprising that heart disease and cancer are the leading causes of death in the United States. Together, heart disease and cancer account for around ** percent of all deaths. Other leading causes of death include accidents, stroke, chronic lower respiratory diseases, and Alzheimer’s disease. However, in 2020 and 2021, COVID-19 was the third leading cause of death in the United States and remained the fourth leading cause of death in 2022, with around **** deaths per 100,000 population. Heart disease in the U.S. In 2023, the death rate from heart disease in the United States was around *** per 100,000 population. The states with the highest rates of death from heart disease are Oklahoma, Mississippi, and Alabama. Coronary heart disease is the most common form of heart disease in the United States. Common risk factors for heart disease include high blood pressure, high cholesterol, smoking, excessive drinking, and being overweight or obese.

Mortality rates for hospitalized COVID–19 patients during the first three and final three months of data collection.

Complications and adverse outcomes among SARS-CoV-2 positive individuals, stratified by race.

Demographic and clinical characteristics of Million Veteran Program participants tested for SARS CoV-2 between March 1, 2020 and August 10, 2020.

IntroductionPatients with multiple myeloma (MM) face heightened infection susceptibility, particularly severe risks from COVID-19. This study, the first systematic review in its domain, seeks to assess the impacts of COVID-19 on MM patients.MethodAdhering to PRISMA guidelines and PROSPERO registration (ID: CRD42023407784), this study conducted an exhaustive literature search from January 1, 2020, to April 12, 2024, using specified search terms in major databases (PubMed, EMBASE, and Web of Science). Quality assessment utilized the JBI Critical checklist, while publication bias was assessed using Egger’s test and funnel plot. The leave-one-out sensitivity analyses were performed to assess the robustness of the results by excluding one study at a time to identify studies with a high risk of bias or those that significantly influenced the overall effect size. Data synthesis involved fitting a random-effects model and estimating meta-regression coefficients.ResultsA total of 14 studies, encompassing a sample size of 3214 yielded pooled estimates indicating a hospitalization rate of 53% (95% CI: 40.81, 65.93) with considerable heterogeneity across studies (I2 = 99%). The ICU admission rate was 17% (95% CI: 11.74, 21.37), also with significant heterogeneity (I2 = 94%). The pooled mortality rate was 22% (95% CI: 15.33, 28.93), showing high heterogeneity (I2 = 97%). The pooled survival rate stood at 78% (95% CI: 71.07, 84.67), again exhibiting substantial heterogeneity (I2 = 97%). Subgroup analysis and meta-regression highlighted that study types, demographic factors, and patient comorbidities significantly contributed to the observed outcome heterogeneity, revealing distinct patterns. Mortality rates increased by 15% for participants with a median age above 67 years. ICU admission rates were positively correlated with obesity, with a 20% increase for groups with at least 19% obesity. Mortality rates rose by 33% for the group of patients with at least 19% obesity, while survival rates decreased by 33% in the same group.ConclusionOur meta-analysis sheds light on diverse COVID-19 outcomes in multiple myeloma. Heterogeneity underscores complexities, and study types, demographics, and co-morbidities significantly influence results, emphasizing the nuanced interplay of factors.

Independent predictors of inpatient mortality in patients with COVID-19 across the entire study period.

BackgroundA new coronavirus was first identified in Wuhan, China in December 2019. Since the times of the 1918 influenza pandemic, malnutrition has been known as a risk factor for severity and mortality from viral pneumonia. Similarly, the recently identified SARS-Cov2 infection (COVID-19) and related pneumonia may be closely linked to malnutrition. Therefore, this study will contribute to new knowledge and awareness of the recording and evaluation of each COVID-19 patient’s nutritional status by assessing the effect of malnutrition on ICU admission and death of COVID-19 patients in developing countries.MethodWe conducted a prospective cohort study in adult COVID-19 patients admitted to selected COVID-19 Isolation and Treatment Centers, Addis Ababa, Ethiopia. Baseline data of the patients were collected using interviewer-administered structured questionnaire and data on the adverse outcomes of follow up were extracted from follow up chart. The main clinical outcomes (ICU admission and death) were captured every week of follow up. We ran a multivariate Cox’s regression analysis to determine the relationship between malnutrition at admission and its effect on ICU admission and death.ResultsA total of 581 COVID-19 patients were enrolled. From the total of recruited patients, 346 (59.6%) were males and 235 (40.4%) were females. The mean age of the respondents was 55 years (16.45) years. The Cox proportional hazard model controlled for sex, age group, number of co-morbidities, and number of medications found that malnutrition at admission was associated with ICU admission and death. When compared to well-nourished patients, the rate of ICU admission was significantly associated and found to be higher among underweight [(adjusted hazard ratio (AHR) = 10.02, 95% CI: (8.64–12.10)] and overweight [(AHR = 7.7, 95% CI: (6.41–9.62)] patients. The rate of survival probability was significantly associated and was found to be better among well-nourished patients (AHR = 0.06, 95% CI : (0.01–0.44) when compared with malnourished COVID-19 patients.ConclusionMalnutrition at the time of admission was shown to increase the risk of ICU admission and mortality among COVID-19 patients. Therefore, it is vital to evaluate patients’ nutritional condition early in their admission and provide timely intervention to minimize the effects on patients and the healthcare system.

Demographic- fertility characteristics of COVID-19 infected and control groups (n = 234).

Sign and symptoms and clinical feature of COVID-19 infected pregnant women (n = 100).

Comparison of pregnancy and neonatal outcome in two groups COVID-19 infected and control groups (n  =  234).