As of 2022, South Africa's population increased and counted approximately 60.6 million inhabitants in total, of which the majority (roughly 49.1 million) were Black Africans. Individuals with an Indian or Asian background formed the smallest population group, counting approximately 1.56 million people overall. Looking at the population from a regional perspective, Gauteng (includes Johannesburg) is the smallest province of South Africa, though highly urbanized with a population of nearly 16 million people.

Increase in number of households

The total number of households increased annually between 2002 and 2022. Between this period, the number of households in South Africa grew by approximately 65 percent. Furthermore, households comprising two to three members were more common in urban areas (39.2 percent) than they were in rural areas (30.6 percent). Households with six or more people, on the other hand, amounted to 19.3 percent in rural areas, being roughly twice as common as those in urban areas.

Main sources of income

The majority of the households in South Africa had salaries or grants as a main source of income in 2019. Roughly 10.7 million drew their income from regular wages, whereas 7.9 million households received social grants paid by the government for citizens in need of state support.

As of 2024, South Africa's population increased, counting approximately 63 million inhabitants. Of these, roughly 27.5 million were aged 0-24, while 654,000 people were 80 years or older. Gauteng and Cape Town are the most populated South Africa’s yearly population growth has been fluctuating since 2013, with the growth rate dropping below the world average in 2024. The majority of people lived in the borders of Gauteng, the smallest of the nine provinces in terms of land area. The number of people residing there amounted to 16.6 million in 2023. Although the Western Cape was the third-largest province, the city of Cape Town had the highest number of inhabitants in the country, at 3.4 million. An underemployed younger population South Africa has a large population under 14, who will be looking for job opportunities in the future. However, the country's labor market has had difficulty integrating these youngsters. Specifically, as of the fourth quarter of 2024, the unemployment rate reached close to 60 percent and 384 percent among people aged 15-24 and 25–34 years, respectively. In the same period, some 27 percent of the individuals between 15 and 24 years were economically active, while the labor force participation rate was higher among people aged 25 to 34, at 74.3 percent.

South Africa is the sixth African country with the largest population, counting approximately 60.5 million individuals as of 2021. In 2023, the largest city in South Africa was Cape Town. The capital of Western Cape counted 3.4 million inhabitants, whereas South Africa's second largest city was Durban (eThekwini Municipality), with 3.1 million inhabitants. Note that when observing the number of inhabitants by municipality, Johannesburg is counted as largest city/municipality of South Africa.

From four provinces to nine provinces

Before Nelson Mandela became president in 1994, the country had four provinces, Cape of Good Hope, Natal, Orange Free State, and Transvaal and 10 “homelands” (also called Bantustans). The four larger regions were for the white population while the homelands for its black population. This system was dismantled following the new constitution of South Africa in 1996 and reorganized into nine provinces. Currently, Gauteng is the most populated province with around 15.9 million people residing there, followed by KwaZulu-Natal with 11.68 million inhabiting the province. As of 2022, Black African individuals were almost 81 percent of the total population in the country, while colored citizens followed amounting to around 5.34 million.

A diverse population

Although the majority of South Africans are identified as Black, the country’s population is far from homogenous, with different ethnic groups usually residing in the different “homelands”. This can be recognizable through the various languages used to communicate between the household members and externally. IsiZulu was the most common language of the nation with around a quarter of the population using it in- and outside of households. IsiXhosa and Afrikaans ranked second and third with roughly 15 percent and 12 percent, respectively.

Polymorphisms of the vitamin D receptor gene (VDR) have been associated inconsistently with various diseases, across populations of diverse origin. The T(f) allele of the functional SNP FokI, in exon 2 of VDR, results in a longer vitamin D receptor protein (VDR) isoform, proposed to be less active. Genetic association of VDR with disease is likely confounded by ethnicity and environmental factors such as plasma 25(OH)D3 status. We hypothesized that VDR expression, VDR level and transactivation of target genes, CAMP and CYP24A1, depend on vitamin D, ethnicity and FokI genotype. Healthy volunteers participated in the study (African, n = 40 and White, n = 20). Plasma 25(OH)D3 levels were quantified by LC-MS and monocytes cultured, with or without 1,25(OH)2D3. Gene expression and protein level was quantified using qRT-PCR and flow cytometry, respectively. Mean plasma 25(OH)D3 status was normal and not significantly different between ethnicities. Neither 25(OH)D3 status nor 1,25(OH)2D3 supplementation significantly influenced expression or level of VDR. Africans had significantly higher mean VDR protein levels (P<0.050), nonetheless transactivated less CAMP expression than Whites. Genotyping the FokI polymorphism by pyrosequencing together with HapMap data, showed a significantly higher (P<0.050) frequency of the CC genotype in Africans than in Whites. FokI genotype, however, did not influence VDR expression or VDR level, but influenced overall transactivation of CAMP and 1,25(OH)2D3-elicited CYP24A1 induction; the latter, interacting with ethnicity. In conclusion, differential VDR expression relates to ethnicity, rather than 25(OH)D3 status and FokI genotype. Instead, VDR transactivation of CAMP is influenced by FokI genotype and, together with ethnicity, influence 1,25(OH)2D3-elicited CYP24A1 expression. Thus, the expression and role of VDR to transactivate target genes is determined not only by genetics, but also by ethnicity and environment involving complex interactions which may confound disease association.