The polycystic kidney disease (PKD) domain is an 80-90 amino acid module originally found in 16 copies in the extracellular segment of polycystin-1, a large cell surface glycoprotein. Polycystin-1 is encoded by the PKD1 gene, which is mutated in autosomal dominant polycystic kidney disease (ADPKD).Although its function is unknown, it may be involved in protein-protein and protein-carbohydrate interactions based on its predicted domain structure. One or more copies of the PKD domain are also found in several other extracellular proteins from higher organisms, eubacteria, and archaebacteria. Singles copies of the PKD domain are found in the melanocytes heavily glycosylated cell-surface proteins Pmel 17, MMP and Nmp. Some bacterial collagenases and proteases also contain a single PKD domain adjacent to their catalytic domains, whereas four copies are present in the heavily glycosylated surface layer protein of archaebacteria . The PKD modules are often observed, within a same protein sequence, in association with FnIII domains .The most conserved motif is the WDFGDGS sequence that is found in the central part of many PKD domains and could play a structural role . Determination of the solution structure of the first PKD domain from human polycystin-1 has shown that the module is built from two β-sheet, one of three strands and one of four strands, which are packed face-to-face .

Autosomal dominant polycystic kidney disease (ADPKD) impacts 1 in 400 to 1 in 1000 live births and accounts for about 4.6% of the kidney replacement population in the US. Hypertension is the most common manifestation and an important risk factor for its progression to end stage renal disease (ESRD) and cardiovascular morbidity and mortality.

The HALT Progression of Polycystic Kidney Disease (HALT PKD) studies were two simultaneous multicenter clinical trials designed to test the efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and the decline in renal function in ADPKD. Specifically, the studies assessed the effects of ACE-I/ARB combination therapy as compared to ACE-I monotherapy in hypertensive ADPKD subjects.

The two studies varied on eligibility criteria (particularly kidney function), blood pressure treatment, and primary outcome measure. Study A investigates treatment effects on individuals with early ADPKD and implements a standard (120-130/70-80 mm Hg) vs. low (95-110/60-75 mmHg) blood pressure control target for both treatment arms in a 2x2 design. Study B investigates treatment effects on individuals with moderately advanced ADPKD in the setting of standard blood pressure control (110-130/80 mm Hg). Participants enrolled in study A were followed for at least five years, while those enrolled in study B were followed for five to eight years, with the average length of follow-up being six and a half years.

The complete HALT PKD data package is available for request.

MRI images for HALT PKD participants are not included in the package, but are available upon request.

Browser serves as repository of variants across exomes and targeted panel sequencing of individuals with polycystic kidney disease. Used to aggregate and harmonize exome and genome sequencing data from sequencing projects of PKD and to make summary data available to the wider scientific community.

This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold .

Consent PKD

pkd/marxism-small dataset hosted on Hugging Face and contributed by the HF Datasets community

FunCoup network information for gene PKD in Homo sapiens. KPCD1_HUMAN Serine/threonine-protein kinase D1

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The PKD (Polycystic Kidney Disease) domain was first identified in the Polycystic Kidney Disease protein, polycystin-1 (PDK1 gene), and contains an Ig-like fold consisting of a β-sandwich of seven strands in two sheets with a Greek key topology, although some members have additional strands . Polycystin-1 is a large cell-surface glycoprotein involved in adhesive protein-protein and protein-carbohydrate interactions; however it is not clear if the PKD domain mediates any of these interactions.

Poland Wholesale Sales Index: PKD 2007: Goods: TE: Wholesale Enterprises (WE) data was reported at 113.700 Same Mth PY=100 in Oct 2018. This records an increase from the previous number of 106.500 Same Mth PY=100 for Sep 2018. Poland Wholesale Sales Index: PKD 2007: Goods: TE: Wholesale Enterprises (WE) data is updated monthly, averaging 105.950 Same Mth PY=100 from Nov 2007 (Median) to Oct 2018, with 132 observations. The data reached an all-time high of 128.400 Same Mth PY=100 in Feb 2008 and a record low of 88.000 Same Mth PY=100 in Feb 2009. Poland Wholesale Sales Index: PKD 2007: Goods: TE: Wholesale Enterprises (WE) data remains active status in CEIC and is reported by Central Statistical Office. The data is categorized under Global Database’s Poland – Table PL.H012: Wholesale Sales Index: Same Month Previous Year=100.

Poland Retail Sales Index: PKD 2007: Goods: Others data was reported at 110.600 Same Mth PY=100 in Jun 2018. This records an increase from the previous number of 108.800 Same Mth PY=100 for May 2018. Poland Retail Sales Index: PKD 2007: Goods: Others data is updated monthly, averaging 101.700 Same Mth PY=100 from Nov 2007 (Median) to Jun 2018, with 128 observations. The data reached an all-time high of 121.000 Same Mth PY=100 in Feb 2008 and a record low of 84.800 Same Mth PY=100 in Aug 2015. Poland Retail Sales Index: PKD 2007: Goods: Others data remains active status in CEIC and is reported by Central Statistical Office. The data is categorized under Global Database’s Poland – Table PL.H002: Retail Sales Index: Same Month Previous Year=100.

Poland GDP: GVA: PKD 2007: Industry data was reported at 245,277.100 PLN mn in Dec 2024. This records an increase from the previous number of 156,033.600 PLN mn for Sep 2024. Poland GDP: GVA: PKD 2007: Industry data is updated quarterly, averaging 92,922.600 PLN mn from Mar 2002 (Median) to Dec 2024, with 92 observations. The data reached an all-time high of 245,277.100 PLN mn in Dec 2024 and a record low of 38,034.800 PLN mn in Jun 2002. Poland GDP: GVA: PKD 2007: Industry data remains active status in CEIC and is reported by Statistics Poland. The data is categorized under Global Database’s Poland – Table PL.A021: ESA 2010: GDP: by Industry: Current Price.

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Die Liste gibt Auskunft darüber, in welchen Gewässern die Fischkrankheit PKD (proliferative Nierenkrankheit) nachgewiesen werden konnte. Die Diagnose beruht auf dem Nachweis des Erregers im histologischen Schnittpräparat (durchgeführt am Zentrum für Fisch- und Wildtiermedizin). Die Liste widerspiegelt den momentanen Wissensstand der Verbreitung der Krankheit. Sie wird laufend aktualisiert.

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The REJ (Receptor for Egg Jelly) domain is found in PKD1 [swissprot:P98161] and the sperm receptor for egg jelly [swissprot:Q26627] . The exact function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.Sequence similarity between a region of the autosomal dominant polycystic kidney disease (ADPKD) protein, polycystin-1 and a sea urchin sperm glycoprotein involved in fertilization, the receptor for egg jelly (suREJ) has been known for some time. The suREJ protein binds the glycoprotein coat of the egg (egg jelly), triggering the acrosome reaction, which transforms the sperm into a fusogenic cell. The sequence similarity and expression pattern suggests that the predicted human PKDREJ protein is a mammalian equivalent of the suREJ protein and therefore may have a central role in human fertilization .

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The main entity of this document is a entry with accession number SSF49299