This dataset provides values for MANUFACTURING PMI reported in several countries. The data includes current values, previous releases, historical highs and record lows, release frequency, reported unit and currency.

In March 2025, the Composite Purchasing Managers Index (PMI) in the United Kingdom was 52, compared with 50.5 in the previous month. Following the COVID-19 outbreak, the composite PMI fell from 53 in February 2020, to 13.8 by April, highlighting the dire economic situation brought on by the pandemic. The composite PMI recovered from July onwards, but fell to 49 in November 2020, with a slight recovery in December preceding an even further drop to 41.2 in January 2021.

This dataset provides values for CONSTRUCTION PMI reported in several countries. The data includes current values, previous releases, historical highs and record lows, release frequency, reported unit and currency.

(CDID: RYCQ) Year - UK National Accounts, The Blue Book time series Datasets for each of the chapters in The Blue Book 2023 including the national accounts at a glance, financial and non-financial corporations, households and non-profit institutions serving households and summary supply and use tables.

Indicator : Regional Future Business Activity IndexTheme : Monthly BusinessSource : NatWest, UK regional PMI report Frequency : MonthlyDefinition : Based on how optimistic a business is for the upcoming 12 months. The index is the sum of the percentage of ‘higher’ responses and half the percentage of ‘unchanged’ responses. The indices vary between 0 and 100, with a reading above 50 indicating an overall increase compared to the previous month, and below 50 an overall decrease. The indices are then seasonally adjusted. Latest Period : August 2024Released : September 2024Next Update : October 2024 Link : https://www.natwest.com/business/insights/economics/economic-outlook.html

The UK health and medical insurance market, valued at approximately £8.17 billion in 2025, is projected to experience robust growth, driven by several key factors. Rising healthcare costs, coupled with an aging population and increasing prevalence of chronic diseases, are placing significant pressure on the National Health Service (NHS). This is leading to a surge in demand for private medical insurance (PMI) among individuals and employers seeking faster access to specialist care and shorter waiting times. The market is segmented by product type (Private Medical Insurance – individual and group policies; Healthcare Cash Plans; Dental Insurance Plans) and procurement type (self-pay and employer-sponsored). The growth of employer-sponsored health coverage reflects a trend among businesses to offer competitive benefits packages to attract and retain talent. Furthermore, technological advancements, such as telehealth and digital health platforms, are improving accessibility and efficiency within the sector, fueling further market expansion. Competitive pressures from established players like Bupa, AXA PPP, and Aviva, alongside the emergence of newer entrants, are fostering innovation and driving down costs in specific segments. However, market growth is not without its restraints. Regulatory changes, economic uncertainties, and concerns over affordability, particularly for individual policies, pose challenges to the market's expansion. The increasing cost of premiums, alongside concerns about policy exclusions and limitations, can impact consumer adoption. Despite these challenges, the long-term outlook for the UK health and medical insurance market remains positive. The projected Compound Annual Growth Rate (CAGR) of 4.56% suggests a considerable increase in market value over the forecast period (2025-2033). This growth is likely to be driven primarily by the continued demand for private healthcare solutions, supplemented by ongoing technological advancements and an evolving regulatory landscape that shapes both competition and consumer access. Recent developments include: On November 2022, in partnership with online platform JAAQ in a six-month trial for boosting access to personalised expert-led health advice online. This adds to Bupa's mental health support which provides ongoing, around-the-clock support for a wealth of mental health conditions, such as anxiety, depression and addiction., On February 2022, AXA UK&I acquired renewable rights to Ageas UK's commercial business at an initial consideration of 47.5 million GBP. This acquisition will strengthen AXA's growth strategy and commitment to its commercial business customers and broker partnerships, particularly in the SME and Schemes market segments. As part of the agreement, around 100 Ageas UK employees will move to AXA Commercial to provide ongoing support and service delivery.. Notable trends are: Global Economic Slowdown and Better Government Insurance Services Affecting the United Kingdom Health and Medical Insurance.

Over the five years through 2024-25, the Financial Management industry's revenue is set to dip at a compound annual rate of 0.2% to £13.7 billion, caused by unfavourable demand conditions following the cost-of-living crisis and the COVID-19 outbreak. The pandemic damaged mergers and acquisitions, dropping from £55.6 billion in 2019 to £16.3 billion in 2020 according to the ONS. The cost-of-living crisis further reduced consumer spending, extending economic difficulties into winter 2023 and triggering a recession. These factors decreased business investments in financial management services as companies focused on cutting costs. Despite these obstacles, the industry maintained stability by offering countercyclical services, aiding businesses in efficient cost management while maintaining operations. Since the EU's 2016 Audit Regulation and Directive limited non-audit fees, financial managers have expanded client bases and explored new income sources to balance these caps. With a 2026 deadline to separate audits from non-audit services, pressure is high, particularly for top companies like the Big Four. Technological advancements are also enabling companies to perform tasks internally that were traditionally outsourced to consultants, tightening the market, especially for smaller clients. Intensified competition and decreased demand are driving the financial management sector towards greater innovation. Following a five-year downturn, business spending has begun to recover in 2024-25, driven by increased M&A activity. Business confidence reached an 11-month high in March 2024, according to S&P Global Flash UK PMI. With inflation cooling to 3.2% in March 2024 from 10.1% the previous year, more resources have been available for financial management and M&A efforts. Revenue is expected to grow by 4.9% in 2024-25. Over the five years through 2029-30, industry revenue is forecast to swell at a compound annual rate of 3.3% to reach £16.1 billion. Improving economic conditions and continued business confidence will push more businesses to increase their spending and invest in M&A activity, increasing demand for advice on managing their finances. In addition, continued low inflation will aid costs for both financial managers and their clients, bolstering profit.

IntroductionDespite the tobacco industry’s (TI) decades-long history of manipulating science, Philip Morris International (PMI) now frames itself as a benevolent funder of science and, in 2017, launched a new scientific organisation, the Foundation for a Smoke-Free World (FSFW). With concerns mounting that PMI’s actions are echoing historical TI influence on science, we aimed to understand the extent to which the public trusts PMI’s involvement in science, and whether channelling funds through a third-party organisation affects these levels of trust.MethodsThrough a representative survey of the UK public (n=1580) we investigated trust in direct (PMI), indirect (FSFW), and no (Cancer Research UK) TI involvement in science. Conservative worldview was investigated as a possible predictor of trust. Structural equation modelling was used to explore associations between variables.ResultsAlthough PMI was significantly less trusted than FSFW and Cancer Research UK, the public did not completely distrust it as a scientific source. Trust in FSFW’s involvement in science was higher before participants understood its TI funding. People with conservative worldviews demonstrated greater trust in TI involvement in science.DiscussionThe UK public needs to be better informed that the TI is not a trustworthy scientific source. Since channelling TI research funds through a third party increases the perceived trustworthiness of its science, steps to prevent such relationships are warranted. People with conservative leanings hold concerning views on TI involvement in science, which may be particularly hard to correct.

Indicator : Regional Business Activity IndexTheme : Monthly BusinessSource : NatWest, UK regional PMI report Frequency : MonthlyDefinition : The PMI Business Activity Index is the first fact-based indicator of regional economic health published each month, tracking the monthly change in the output of goods and services across the private sector. A reading above 50 signals growth, and the further above the 50 level the faster the expansion signalled.Latest Period : August 2024Released : September 2024Next Update : October 2024 Link : https://www.natwest.com/business/insights/economics/economic-outlook.html

This statistic displays the share of adults in the United Kingdom (UK) that had private medical insurance (PMI) in 2017, by age groups. Those aged between 45 and 54 were the most likely to have private medical insurance in 2017 with ** percent of insurance covers by that age group. Those aged between 18 and 24 years only made up for * percent of private medical insurance owners.

The United Kingdom Health and Medical Insurance Market is Segmented by Policy Type (Individual Policies, Group/Corporate Policies), Coverage Type (In-Patient Only, Comprehensive, and More), Distribution Channel (IFAs, Direct-To-Consumer, Bancassurance & Affinity Partnerships, and More), End User (Individuals & Families, Smes, and More), and Region. The Market Forecasts are Provided in Value (USD).

Phosphomannose isomerase (EC 5.3.1.8) (PMI) is the enzyme that catalyzesthe interconversion of mannose-6-phosphate and fructose-6-phosphate. Ineukaryotes, it is involved in the synthesis of GDP-mannose which is aconstituent of N- and O-linked glycans as well as GPI anchors. In prokaryotes,it is involved in a variety of pathways including capsular polysaccharidebiosynthesis and D-mannose metabolism.Three classes of PMI have been defined on the basis of sequence similarities. The first class comprises all known eukaryotic PMI as well as the enzymeencoded by the manA gene in enterobacteria such as Escherichia coli. Class IPMI's are proteins of about 42 to 50 Kd which bind a zinc ion essential fortheir activity.As signature patterns for class I PMI, we selected two conserved regions. Thefirst one is located in the N-terminal section of these proteins, the secondin the C-terminal half. Both patterns contain a residue involved in thebinding of the zinc ion.

Mannose-6-phosphate isomerase or phosphomannose isomerase ([ec:5.3.1.8]) (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N-and O-linked glycans and GPI anchors and in prokaryotes it participates in a variety of pathways, including capsular polysaccharide biosynthesis and D-mannose metabolism. PMI's belong to the cupin superfamily whose functions range from isomerase and epimerase activities involved in the modification of cell wall carbohydrates in bacteria and plants, to non-enzymatic storage proteins in plant seeds, and transcription factors linked to congenital baldness in mammals . Three classes of PMI have been defined .

Philip Morris International Inc. (PMI) is undertaking the expansion of the tobacco manufacturing facility in Bologna, Emilia-Romagna, Italy.The project involves the expansion of a tobacco manufacturing facility. It includes construction of a production unit, processing units, a storage unit, an administrative facility, and related infrastructure and the installation of machinery.Construction works are underway. Read More

Mannose-6-phosphate isomerase or phosphomannose isomerase ([ec:5.3.1.8]) (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N-and O-linked glycans and GPI anchors and in prokaryotes it participates in a variety of pathways, including capsular polysaccharide biosynthesis and D-mannose metabolism. PMI's belong to the cupin superfamily whose functions range from isomerase and epimerase activities involved in the modification of cell wall carbohydrates in bacteria and plants, to non-enzymatic storage proteins in plant seeds, and transcription factors linked to congenital baldness in mammals . Three classes of PMI have been defined .

Proteomic analyses of human tissues are sometimes conducted on autopsy samples. However, no comparative analysis between proteomic data derived from autopsy samples and fresh frozen samples has been undertaken, nor has there been an assessment of the post-mortem interval (PMI) influences on protein quantification. In the current study, 94 human left anterior descending (LAD) coronary artery were collected from deceased patients. Proteins were analysed using nanoflow liquid chromatography-tandem mass spectrometry. Data were processed with Proteome Discoverer and Mascot. The correlations between the protein abundances and the PMI were calculated. DAVID software was used for pathway and GO annotation enrichment. Among consistently quantified proteins, approximately 40% of the protein abundances exhibited significant correlations with PMI, most of which being inverse. Notably, smooth muscle cell markers displayed substantial reduction with prolonged PMI. Conversely, positive correlations with PMI were observed for immunoglobulins, coagulation factors, and complement factors, including coagulation factor XII, plasminogen, and lactotransferrin. Comparative analyses of sex differences between autopsy LAD samples and fresh-frozen LAD samples (n=65) showed no concordance in protein quantification. However, a robust correlation was observed within a sex comparison conducted between fresh-frozen carotid endarterectomies (CEA) from 2 different cohorts (n=104 and n=200). This study represents the first large-scale proteomics investigation into the influence of PMI on the protein composition of human vasculature. We observed significant correlations with PMI for nearly 40% of the consistently quantified proteins. Our findings underscore potential discrepancies in the quantitative accuracy of proteomics data derived from autopsy samples. Consequently, results obtained from post-mortem specimens may not be reproducible in fresh-frozen samples.

Mannose-6-phosphate isomerase or phosphomannose isomerase ([ec:5.3.1.8]) (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N-and O-linked glycans and GPI anchors and in prokaryotes it participates in a variety of pathways, including capsular polysaccharide biosynthesis and D-mannose metabolism. PMI's belong to the cupin superfamily whose functions range from isomerase and epimerase activities involved in the modification of cell wall carbohydrates in bacteria and plants, to non-enzymatic storage proteins in plant seeds, and transcription factors linked to congenital baldness in mammals . Three classes of PMI have been defined .

This enzyme is known to be bifunctional, as both mannose-6-phosphate isomerase ([ec:5.3.1.8]) (PMI) and mannose-1-phosphate guanylyltransferase ([ec:2.7.7.22]) in Pseudomonas aeruginosa , Xanthomonas campestris , and Acetobacter xylinus. The literature on the enzyme from Escherichia coli attributes mannose-6-phosphate isomerase activity to an adjacent gene, but the present sequence has not been shown to lack the activity. The PMI domain lies at the C-terminal.

Further hikes in duty in 2012 are believed to have further stimulated the nonduty paid sector with volumes at 3.11 billion pieces, equivalent to 19% of total sales. Another fall in 2009 pushed value down to €2,439 million, although price rises and a slight rise in volumes raised value by 11.4% in 2010 to €2,718 million and by 6.2% in 2012 to €2,714 million. Forecasts for 2013 predict a further, if more modest, 1.2% increase to €2,747 million Forecasts for 2013 suggest that JTI is making good progress at the expense of PMI with volumes up 4.2% in Q1 2013 compared to Q1 2012. ERC forecasts 34.4% for JTI by the end of 2013 with a reduced 35% for PMI. Read More

Colombia is one of the larger cigarette markets in South America, although it has long suffered from a contraband problem, which has impacted upon duty paid demand. Today, the market is contested between the two leading multinationals, Philip Morris International (PMI) and British American Tobacco (BAT), with PMI currently holding a slender lead over BAT. PMI operates through Philip Morris Colombia and its manufacturing arm, Coltabaco, which has a factory at Medellin. Read More