Between 1821 and 1921, the entire island of Ireland was a part of the United Kingdom of Great Britain and Ireland, after both islands were united by the Act of Union in 1800. This graph shows only the population of the six counties of Ireland that would go on to become Northern Ireland. The population was just under 1.4 million in 1821 and grew to 1.7 million in the next twenty years.

Between 1845 and 1849 the Great Famine devastated the overall population of Ireland, causing the deaths of approximately one million people, and causing a further million to emigrate. Although the famine affected the population of the west and south of Ireland much more severely than the north, the population of the six counties still fell by over 200,000 people between 1841 and 1851. The population then continued to fall, reaching it's lowest point in the 1890s where it was 1.2 million. The Northern Irish population then grows slowly until the mid to late 1900s, during which time the state of Northern Ireland was founded in 1921. The population the reaches over 1.54 million in the 1960s, before it falls again in the 1970s. This drop in population coincides with the outbreak and the most violent decade of the Troubles in Northern Ireland, which was a conflict that dominated Northern Irish daily life for decades. However, from 1981 onwards the population grows by 70,000 to 12,000 every ten years, surpassing it's pre-famine level in the 1990s.

The 2021 Northern Ireland Census marked the first time since records began where the Catholic share of the population was larger than the combined Protestant share. In 2021, over 42 percent of the population classified themselves as Catholic or from a Catholic background, in comparison with 37 percent classified as Protestant or from a Protestant background. Additionally, the share of the population with no religion (or those who did not answer) was 19 percent; larger than any individual Protestant denomination. This marks a significant shift in demographic and societal trends over the past century, as Protestants outnumbered Catholics by roughly 2:1 when Northern Ireland was established in the 1920s. Given the Catholic community's historic tendency to be in favor of a united Ireland, many look to the changing religious composition of the population when assessing the potential for Irish reunification. Religion's historical influence A major development in the history of British rule in ireland was the Plantation of Ulster in the 1600s, where much of the land in the north (historically the most rebellious region) was seized from Irish Catholics and given to Protestant settlers from Britain (predominantly Scots). This helped establish Protestant dominance in the north, created a large section of the population loyal to the British crown, and saw a distinct Ulster-Scots identity develop over time. In the 1920s, the republican movement won independence for 26 of Ireland's 32 counties, however, the six counties in Ulster with the largest Protestant populations remained part of the UK, as Northern Ireland. Following partition, structural inequalities between Northern Ireland's Protestant and Catholic communities meant that the Protestant population was generally wealthier, better educated, more politically empowered, and had better access to housing, among other advantages. In the 1960s, a civil rights movement then emerged for equal rights and status for both sides of the population, but this quickly turned violent and escalated into a the three-decade long conflict now known as the Troubles.

The Troubles was largely fought between nationalist/republican paramilitaries (mostly Catholic), unionist/loyalist paramilitaries (mostly Protestant), and British security forces (including the police). This is often described as a religious conflict, however it is more accurately described as an ethnic and political conflict, where the Catholic community generally favored Northern Ireland's reunification with the rest of the island, while the Protestant community wished to remain in the UK. Paramilitaries had a large amount of support from their respective communities in the early years of the Troubles, but this waned as the conflict progressed into the 1980s and 1990s. Demographic and societal trends influenced the religious composition of Northern Ireland's population in these decades, as the Catholic community had higher fertility rates than Protestant communities, while the growing secularism has coincided with a decline in those identifying as Protestant - the dip in those identifying as Catholic in the 1970s and 1980s was due to a protest and boycott of the Census. The Troubles came to an end in 1998, and divisions between both sides of the community have drastically fallen, although they have not disappeared completely.

At the beginning of the 1840s, life expectancy from birth in Ireland was just over 38 years. However, this figure would see a dramatic decline with the beginning of the Great Famine in 1845, and dropped below 21 years in the second half of the decade (in 1849 alone, life expectancy fell to just 14 years). The famine came as a result of a Europe-wide potato blight, which had a disproportionally devastating impact on the Irish population due to the dependency on potatoes (particularly in the south and east), and the prevalence of a single variety of potato on the island that allowed the blight to spread faster than in other areas of Europe. Additionally, authorities forcefully redirected much of the country's surplus grain to the British mainland, which exacerbated the situation. Within five years, mass starvation would contribute to the deaths of over one million people on the island, while a further one million would emigrate; this also created a legacy of emigration from Ireland, which saw the population continue to fall until the mid-1900s, and the total population of the island is still well below its pre-famine level of 8.5 million people.

Following the end of the Great Famine, life expectancy would begin to gradually increase in Ireland, as post-famine reforms would see improvements in the living standards of the country’s peasantry, most notably the Land Wars, a largely successful series of strikes, boycotts and protests aimed at reform of the country's agricultural land distribution, which began in the 1870s and lasted into the 20th century. As these reforms were implemented, life expectancy in Ireland would rise to more than fifty years by the turn of the century. While this rise would slow somewhat in the 1910s, due to the large number of Irish soldiers who fought in the First World War and the Spanish Flu pandemic, as well as the period of civil unrest leading up to the island's partition in 1921, life expectancy in Ireland would rise greatly in the 20th century. In the second half of the 20th century, Ireland's healthcare system and living standards developed similarly to the rest of Western Europe, and today, it is often ranks among the top countries globally in terms of human development, GDP and quality of healthcare. With these developments, the increase in life expectancy from birth in Ireland was relatively constant in the first century of independence, and in 2020 is estimated to be 82 years.