In 1800, the population of the region of present-day India was approximately 169 million. The population would grow gradually throughout the 19th century, rising to over 240 million by 1900. Population growth would begin to increase in the 1920s, as a result of falling mortality rates, due to improvements in health, sanitation and infrastructure. However, the population of India would see it’s largest rate of growth in the years following the country’s independence from the British Empire in 1948, where the population would rise from 358 million to over one billion by the turn of the century, making India the second country to pass the billion person milestone. While the rate of growth has slowed somewhat as India begins a demographics shift, the country’s population has continued to grow dramatically throughout the 21st century, and in 2020, India is estimated to have a population of just under 1.4 billion, well over a billion more people than one century previously. Today, approximately 18% of the Earth’s population lives in India, and it is estimated that India will overtake China to become the most populous country in the world within the next five years.

In 1498, Vasco da Gama became the first known European to sail to India by circumventing Africa, which ushered in a new age of European sea trade with Asia. Initially, Indian rulers were unimpressed and wary of the Portuguese, and Muslim traders in the region were hostile, but the Portuguese were able to assess what could be traded for exotic goods (mostly spices) and lucrative trade routes were established after subsequent journeys. Additionally, the Portuguese quickly learned that they had the technological advantage in conflict, and repelled attacks from their Muslim rivals. Fortified trading posts, known as factories, were then established along the African and Asian coasts to protect these trade routes, and these became the foundation upon which the Portuguese Empire (Europe's longest-lasting) was built.

Colonization and competition In 1494, the Treaty of Tordesillas saw Portugal and Spain draw a line through the Atlantic, with each crown laying claim to all non-Christian lands on their respective side. No other European power acknowledged these claims, but it would take almost a century for the British, Dutch, or French to begin establishing their own maritime empires; this meant that the Portuguese had a near-monopoly on the Indian spice trade for almost 100 years, and this was the century when their trade with Asia was most active. Portuguese traders not only did business with merchants in India, but they also explored further, and established trade routes with present-day China, Indonesia, and Japan, and even facilitated trade between these cultures. In the 1590s, the Dutch then followed the Portuguese model of empire building and quickly emerged as Portugal's biggest rival in Asia. VOC The Dutch and Portuguese were in conflict for over 60 years, across four continents, and the Asian and African conflicts are often referred to as the "Spice War". The Netherlands eventually usurped Portugal as the strongest European trading power in Asia by the mid-1600s. Most of the Dutch trade was done through the Dutch East India Company (VOC), which is often considered the most valuable company to have ever existed. In the 17th century, 56 percent of all ships that travelled from the given countries to Asia were Dutch, and the figure was over 44 percent in the following century. Such companies were not only trading enterprises, but also acted in the military and political interests of their respective crowns. The VOC went into decline in the mid-1700s, as the British Empire gained the upper hand in its rivalry with the Netherlands. The British East India Company then consolidated its power on the Indian subcontinent, and Dutch interests were largely centered in the East Indies (present-day Indonesia), which remained a Dutch colony until the Second World War. For France, its primary colonial power in Asia was in French Indochina, made up of present-day Cambodia, Laos, and Vietnam, although the seven European powers had trade connections all over Asia, and all competed or cooperated with one another at various points in these 300 years.

Life expectancy in India was 25.4 in the year 1800, and over the course of the next 220 years, it has increased to almost 70. Between 1800 and 1920, life expectancy in India remained in the mid to low twenties, with the largest declines coming in the 1870s and 1910s; this was because of the Great Famine of 1876-1878, and the Spanish Flu Pandemic of 1918-1919, both of which were responsible for the deaths of up to six and seventeen million Indians respectively; as well as the presence of other endemic diseases in the region, such as smallpox. From 1920 onwards, India's life expectancy has consistently increased, but it is still below the global average.