Between 1500 and 1800, London grew to be the largest city in Western Europe, with its population growing almost 22 times larger in this period. London would eventually overtake Constantinople as Europe's largest in the 1700s, before becoming the largest city in the world (ahead of Beijing) in the early-1800s.

The most populous cities in this period were the capitals of European empires, with Paris, Amsterdam, and Vienna growing to become the largest cities, alongside the likes of Lisbon and Madrid in Iberia, and Naples or Venice in Italy. Many of northwestern Europe's largest cities in 1500 would eventually be overtaken by others not shown here, such as the port cities of Hamburg, Marseilles or Rotterdam, or more industrial cities such as Berlin, Birmingham, and Munich.

In 1500, the largest city was Paris, with an estimated 225 thousand inhabitants, almost double the population of the second-largest city, Naples. As in 1330, Venice and Milan remain the third and fourth largest cities in Western Europe, however Genoa's population almost halved from 1330 until 1500, as it was struck heavily by the bubonic plague in the mid-1300s. In lists prior to this, the largest cities were generally in Spain and Italy, however, as time progressed, the largest populations could be found more often in Italy and France. The year 1500 is around the beginning of what we now consider modern history, a time that saw the birth of many European empires and inter-continental globalization.

It is only in the past two centuries where demographics and the development of human populations has emerged as a subject in its own right, as industrialization and improvements in medicine gave way to exponential growth of the world's population. There are very few known demographic studies conducted before the 1800s, which means that modern scholars have had to use a variety of documents from centuries gone by, along with archeological and anthropological studies, to try and gain a better understanding of the world's demographic development. Genealogical records One such method is the study of genealogical records from the past; luckily, there are many genealogies relating to European families that date back as far as medieval times. Unfortunately, however, all of these studies relate to families in the upper and elite classes; this is not entirely representative of the overall population as these families had a much higher standard of living and were less susceptible to famine or malnutrition than the average person (although elites were more likely to die during times of war). Nonetheless, there is much to be learned from this data. Impact of the Black Death In the centuries between 1200 and 1745, English male aristocrats who made it to their 21st birthday were generally expected to live to an age between 62 and 72 years old. The only century where life expectancy among this group was much lower was in the 1300s, where the Black Death caused life expectancy among adult English noblemen to drop to just 45 years. Experts assume that the pre-plague population of England was somewhere between four and seven million people in the thirteenth century, and just two million in the fourteenth century, meaning that Britain lost at least half of its population due to the plague. Although the plague only peaked in England for approximately eighteen months, between 1348 and 1350, it devastated the entire population, and further outbreaks in the following decades caused life expectancy in the decade to drop further. The bubonic plague did return to England sporadically until the mid-seventeenth century, although life expectancy among English male aristocrats rose again in the centuries following the worst outbreak, and even peaked at more than 71 years in the first half of the sixteenth century.

It is estimated that the cities of Cordova (modern-day Córdoba) and Palermo were the largest cities in Europe in 1050, and had between fifteen and twenty times the population of most other entries in this graph, Despite this the cities of Cordova (the capital city of the Umayyad caliphate, who controlled much of the Iberian peninsula from the seventh to eleventh centuries), and Palermo (another Arab-controlled capital in Southern Europe) were still the only cities in Western Europe with a population over one hundred thousand people, closely followed by Seville. It is also noteworthy to point out that the five largest cities on this list were importing trading cities, in modern day Spain or Italy, although the largest cities become more northern and western European in later lists (1200, 1330, 1500, 1650 and 1800). In 1050, todays largest Western European cities, London and Paris, had just twenty-five and twenty thousand inhabitants respectively.

The period of European history (and much of world history) between 500 and 1500 is today known as the 'Dark Ages'. Although the term 'Dark Ages' was originally applied to the lack of literature and arts, it has since been applied to the lack or scarcity of recorded information from this time. Because of these limitations, much information about this time is still being debated today.