This dataset includes summary physiology and MRI data used in a publication identifying sex differences in insular organization to an autonomic challenge, the hand grip. The protocol consistent of healthy participants performing a series of four 16-second hand grip maneuvers one minute part, with baseline and recovery periods. Continues fMRI whole-brain scans were collected at 2 s intervals, and concurrent pulse oximetry data were acquired. The data include the SaO2 levels and continuous heart rate derived from the pleth waveform. The files include pdf and MATLAB figures, and tables and results from a SAS dataset with statistical results from RMANOVA (see10.12688/f1000research.8252.1 for method). The MRI data with summary T1 files after DARTEL normalization in SPM12 are published in a related dataset in this dataverse (Macey, Paul, 2017, "Summary fMRI and physiology data from Valsalva maneuver in female and male healthy subjects", doi:10.7910/DVN/QOHNFE, Harvard Dataverse, V1), and those fMRI data include the preprocessing whole-brain images (motion-corrected, coregistered to T1, spatially normalized using T1 DARTEL parameters, smoothed 8mm FWHM). Full details will be included in the publication.

List of extracted features.

p-values of the body mass index among different groups.

Statistics of the experimental data set.

Time consumption of the original ICSS and Physio_ICSS.