This statistic depicts the share of the U.S. population who suffered from schizophrenia from 1990 to 2019. As of 2019, around 0.47 percent of the population had schizophrenia.

Sample: 69 patients and 74 matching controls. lC: local clustering; lL: local characteristic path length; lS: local small-worldness; lFCD: local degree. *One way ANOVA: PFWE < 0.05 cluster-level corrected. SPM8 model: one-way ANOVA with gender, age and motion covariates.

The coordinated dynamic interactions of large-scale brain circuits and networks have been associated with cognitive functions and behavior. Recent advances in network neuroscience have suggested that the anatomical organization of such networks puts fundamental constraints on the dynamical landscape of brain activity, i.e., the different states, or patterns of regional activation, and transition between states the brain can display. Specifically, it has been shown that densely connected, central regions control the transition between states that are “easily” reachable (in terms of expended energy), whereas weakly connected areas control transitions to states that are hard-to-reach. Changes in large-scale brain activity have been hypothesized to underlie many neurological and psychiatric disorders. Evidence has emerged that large-scale dysconnectivity might play a crucial role in the pathophysiology of schizophrenia, especially regarding cognitive symptoms. Therefore, an analysis of graph and control theoretic measures of large-scale brain connectivity in patients offers to give insight into the emergence of cognitive disturbances in the disorder. To investigate these potential differences between patients with schizophrenia (SCZ), patients with schizoaffective disorder (SCZaff) and matched healthy controls (HC), we used structural MRI data to assess the microstructural organization of white matter. We first calculate seven graph measures of integration, segregation, centrality and resilience and test for group differences. Second, we extend our analysis beyond these traditional measures and employ a simplified noise-free linear discrete-time and time-invariant network model to calculate two complementary measures of controllability. Average controllability, which identifies brain areas that can guide brain activity into different, easily reachable states with little input energy and modal controllability, which characterizes regions that can push the brain into difficult-to-reach states, i.e., states that require substantial input energy. We identified differences in standard network and controllability measures for both patient groups compared to HCs. We found a strong reduction of betweenness centrality for both patient groups and a strong reduction in average controllability for the SCZ group again in comparison to the HC group. Our findings of network level deficits might help to explain the many cognitive deficits associated with these disorders.

This statistic depicts the share of the population who suffered from schizophrenia worldwide from 1990 to 2019, by gender. As of 2019, around 0.28 percent of females and 0.32 percent of males had schizophrenia.

Graph and download economic data for Medical Services Expenditures by Disease: Mental Illness Price Index, Blended Account Basis (MNINEIPIBLEND) from 2000 to 2021 about mental health, disease, physicians, healthcare, medical, health, expenditures, services, price index, indexes, price, and USA.

In 2023, over 20 percent of Hispanics in the U.S. reported that they had any mental illness in the past year. This statistic shows the percentage of U.S. Hispanic or Latino adults with any mental illness in the past year from 2008 to 2023.

Graph and download economic data for Medical Services Expenditures per Capita by Disease: Mental Illness , MEPS Account Basis (MNINEIPCMEPS) from 2000 to 2021 about mental health, disease, physicians, healthcare, medical, health, expenditures, per capita, services, and USA.

Number of edges from each node.

BackgroundWorking memory (WM) and attention deficits are both important features of schizophrenia. WM is closely related to attention, for it acted as an important characteristic in activating and manipulating WM. However, the knowledge of neural mechanisms underlying the relationship between WM and attention deficits in schizophrenia is poorly investigated.MethodsGraph theory was used to examine the network topology at the whole-brain and large-scale network levels among 125 schizophrenia patients with different severity of attention deficits (65 mild attention deficits; 46 moderate attention deficits; and 14 severe attention deficits) and 53 healthy controls (HCs) during an N-back WM task. These analyses were repeated in the same participants during the resting state.ResultsIn the WM task, there were omnibus differences in small-worldness and normalized clustering coefficient at a whole-brain level and normalized characterized path length of the default-mode network (DMN) among all groups. Post hoc analysis further indicated that all patient groups showed increased small-worldness and normalized clustering coefficient of the whole brain compared with HCs, and schizophrenia with severe attention deficits showed increased normalized characterized path length of the DMN compared with schizophrenia with mild attention deficits and HCs. However, these observations were not persisted under the resting state. Further correlation analyses indicated that the increased normalized characterized path length of the DMN was correlated with more severe attentional deficits and poorer accuracy of the WM task.ConclusionOur research demonstrated that, compared with the schizophrenia patients with less attention deficits, disrupted integration of the DMN may more particularly underlie the WM deficits in schizophrenia patients with severe attention deficits.

Automated classification methods for disease diagnosis are currently in the limelight, especially for imaging data. Classification does not fully meet a clinician's needs, however: in order to combine the results of multiple tests and decide on a course of treatment, a clinician needs the likelihood of a given health condition rather than binary classification yielded by such methods. We illustrate how likelihoods can be derived step by step from first principles and approximations, and how they can be assessed and selected, using fMRI data from a publicly available data set containing schizophrenic and healthy control subjects, as a working example. We start from the basic assumption of partial exchangeability, and then the notion of sufficient statistics and the "method of translation" (Edgeworth, 1898) combined with conjugate priors. This method can be used to construct a likelihood that can be used to compare different data-reduction algorithms. Despite the simplifications and possibly unrealistic assumptions used to illustrate the method, we obtain classification results comparable to previous, more realistic studies about schizophrenia, whilst yielding likelihoods that can naturally be combined with the results of other diagnostic tests.

In 2023, it was estimated that nearly 32 percent of men aged 30 to 34 suffered from some mental illness, and 8.7 percent of those in this age group suffered from serious mental illness. This statistic shows the percentage of U.S. men with any or serious mental illness in the past year in 2023, by age.

In the United States, the prevalence of mental illness in the past year is more common among females than males and more common among the young than the old. As of 2023, some 26.4 percent of females reported some type of mental illness in the past year, compared to 19 percent of males. Common forms of mental illness include depression, anxiety disorders, and mood disorders. Depression Depression is one of the most common mental illnesses in the United States. Depression is defined by prolonged feelings of sadness, hopelessness, and despair leading to a loss of interest in activities once enjoyed, a loss of energy, trouble sleeping, and thoughts of death or suicide. It is estimated that around five percent of the U.S. population suffers from depression. Depression is more common among women with around six percent of women suffering from depression compared to four percent of men. Mental illness and substance abuse Data has shown that those who suffer from mental illness are more likely to suffer from substance abuse than those without mental illness. Those with mental illness are more likely to use illicit drugs such as heroin and cocaine, and to abuse prescription drugs than those without mental illness. As of 2023, around 7.9 percent of adults in the United States suffered from co-occuring mental illness and substance use disorder.

Number of edges from each node.

In 2023, it was estimated that 26.4 percent of women in the U.S. had some type of mental illness in the past year. This statistic shows the percentage of U.S. women who had any mental illness in the past year from 2008 to 2023.

Graph and download economic data for Real Medical Services Expenditures by Disease: Mental Illness , MEPS Account Basis (MNINEIREXMEPS) from 2000 to 2021 about mental health, disease, physicians, healthcare, medical, health, expenditures, services, real, and USA.

Background: Despite the importance of psychosis as a comorbidity of temporal lobe epilepsy (TLE), the underlying neural mechanisms are still unclear. We aimed to investigate abnormalities specific to psychosis in TLE, using diffusion MRI parameters and graph-theoretical network analysis.Material and Methods: We recruited 49 patients with TLE (20 with and 29 without interictal schizophrenia-like psychosis) and 42 age-/gender-matched healthy controls. We performed 3-tesla MRI scans including 3D T1-weighted imaging and diffusion tensor imaging in all participants. Among the three groups, fractional anisotropy (FA), mean diffusivity (MD), and global network metrics were compared by analyses of covariance. Regional connectivity strength was compared by network-based statistics.Results: Compared to controls, TLE patients showed significant temporal and extra-temporal changes in FA, and MD, which were more severe and widespread in patients with than without psychosis. We observed distinct differences between TLE patients with and without psychosis in the anterior thalamic radiation (ATR), inferior fronto-occipital fasciculus (IFOF), and inferior longitudinal fasciculus (ILF). Similarly, for network metrics, global, and local efficiency and increased path length were significantly reduced in TLE patients compared to controls, but with more severe changes in TLE with psychosis than without psychosis. Network-based statistics detected significant differences between TLE with and without psychosis mainly involving the left limbic and prefrontal areas.Conclusion: TLE patients with interictal schizophrenia-like psychosis showed more widespread and severe white matter impairment, involving the ATR, IFOF and ILF, as well as disrupted network connectivity, particularly in the left limbic and prefrontal cortex, than patients without psychosis.

This report presents findings from the third (wave 3) in a series of follow up reports to the 2017 Mental Health of Children and Young People (MHCYP) survey, conducted in 2022. The sample includes 2,866 of the children and young people who took part in the MHCYP 2017 survey. The mental health of children and young people aged 7 to 24 years living in England in 2022 is examined, as well as their household circumstances, and their experiences of education, employment and services and of life in their families and communities. Comparisons are made with 2017, 2020 (wave 1) and 2021 (wave 2), where possible, to monitor changes over time.

Correlations between number of edges (40 + 40 neighbors), using the directed similarity graph, and measures of variability and complexity from previous analyses.

Number of edges from each node. Directed similarity graph.

Additional file 2. Contrast maps.