Distribution of county characteristics by SES and HSS classes, 2010–2012 SEER 17 combined (N = 611).

NA- not assessed/availablelcSSc- limited cutaneous systemic sclerosisdcSSc- diffuse cutaneous systemic sclerosisSSc/PPM- Systemic sclerosis and polymyositis overlapACA- anticentromere antibodySCL-70- anti-SCL 70 antibodyRNA Pol- anti-RNA polymerase III antibody* SCL-70 not assessedDemographics, smoking history and SSc subtype and serology.

NA- not assessed/availableWT: wild typeTumor characteristics and prognosis.

ObjectiveGeographic and racial disparities may contribute to variation in the incidence and outcomes of HIV-associated cancers in the United States.MethodUsing the Surveillance, Epidemiology, and End Results (SEER) database, we analyzed Kaposi sarcoma (KS) incidence and survival by race and geographic region during the combined antiretroviral therapy era. Reported cases of KS in men from 2000 to 2013 were obtained from 17 SEER cancer registries. Overall and age-standardized KS incidence rates were calculated and stratified by race and geographic region. We evaluated incidence trends using joinpoint analyses and calculated adjusted hazard ratios (aHR) for overall and KS-specific mortality using multivariable Cox proportional hazards models.ResultsOf 4,455 KS cases identified in men younger than 55 years (median age 40 years), the annual percent change (APC) for KS incidence significantly decreased for white men between 2001 and 2013 (APC -4.52, p = 0.02). The APC for AA men demonstrated a non-significant decrease from 2000–2013 (APC -1.84, p = 0.09). Among AA men in the South, however, APC has significantly increased between 2000 and 2013 (+3.0, p = 0.03). In addition, compared with white men diagnosed with KS during the same time period, AA men were also more likely to die from all causes and KS cancer-specific causes (aHR 1.52, 95% CI 1.34–1.72, aHR 1.49, 95% CI 1.30–1.72 respectively).ConclusionAlthough overall KS incidence has decreased in the U.S., geographic and racial disparities in KS incidence and survival exist.

*Total lung capacity, in all other cases FVC and TLC were similarNSIP- non-specific interstitial pneumoniaUIP- usual interstitial pneumoniaFib nos- fibrosis not otherwise specifiedEMPHY- emphysemaNA- not assessed/availablePulmonary function testing and Computed Tomography findings.

Accumulated case number and age adjusted incidence rate (AAIR) of hypopharyngeal squamous carcinoma (HPSCC) during 2004–2019.

Multivariate analysis of factors associated survival in patients with distant metastatic hypopharyngeal squamous cell carcinoma.

Multivariate analysis of factors associated with survival in patients with early stage hypopharyngeal squamous cell carcinoma.

Clinicopathological characteristics of patients with HPSCC by stage diagnosed during 2004–2019.

Three- and five- year survival rates in patients with hypopharyngeal squamous cell carcinoma diagnosed during 2004–2019.

*HR = Hazard Ratio **CI = Confidence Interval.

Racial disparity of clinicopathological features in HPSCC patients diagnosed during 2004–2015.

Results of univariable analysis for both OS and CSS among newly diagnosed NSCLC patients aged ≥ 65 years in the SEER-17 database.

Subgroup analysis of both OS and CSS among patients aged ≥65 years with newly diagnosed stage III inoperable NSCLC treated with RT alone or RT + CT in the SEER-17 database.

Baseline characteristics of prostate cancer patients with bone metastases, 17 SEER registries, 2010-2021.

12, 36-, and 60-month cancer-specific and overall survival rates in prostate cancer patients with bone metastasis, 17 SEER registries, 2010–2021.

Introduction: Research on esophageal squamous cell carcinoma (ESCC) in Asian American (AsA) populations frequently aggregates data, thereby overlooking the considerable diversity inherent within this demographic. The aim of this study was to investigate the variations in ESCC characteristics and clinical outcomes among AsA. Methods: Patients diagnosed with ESCC were identified through the Surveillance, Epidemiology, and End Results (SEER) 17 database. The AsA cohort was categorized into specific subgroups: Chinese, Japanese, Filipino, Korean, Vietnamese, South Asian (Asian Indian or Pakistani), and other Asian. The Kaplan-Meier method was employed to estimate unadjusted overall survival (OS), while Cox proportional hazards models were utilized to assess adjusted OS. Results: A total of 9,252 patients were included, with the cohort comprising 1,100 Asian, 2,135 Black, 951 Hispanic, and 5,066 White individuals. AsA patients demonstrated the highest unadjusted OS (P < .001). The Vietnamese subgroup exhibited the highest proportion of male patients at 92.1%. South Asian patients showed the highest unadjusted OS among the distinct Asian subgroups, with survival rates of 56% at one year (95% CI 49–64), 31% at three years (95% CI 25–40), and 23% at five years (95% CI 17–32). After adjusting, only Chinese and South Asian patients displayed significantly improved OS compared to the White reference group (P < .05). Conclusion: Considerable disparities in ESCC characteristics and outcomes exist among AsA populations. Socioeconomic, genetic, and epigenetic factors may influence these differences. Further research is essential to clarify the mechanisms of this discrepancy.