West Virginia is currently the state with the highest drug overdose death rate in the United States, with 91 deaths per 100,000 population in 2022. Although West Virginia had the highest drug overdose death rate at that time, California was the state where the most people died from drug overdose. In 2022, around 10,952 people in California died from a drug overdose. The main perpetrator Opioids account for the majority of all drug overdose deaths in the United States. Opioids include illegal drugs such as heroin, legal prescription drugs like oxycodone, and illicitly manufactured synthetic drugs like fentanyl. The abuse of opioids has increased in recent years, leading to an increased number of drug overdose deaths. The death rate from heroin overdose hit an all-time high of 4.9 per 100,000 population in 2016 and 2017, but has decreased in recent years. Now, illicitly manufactured synthetic opioids such as fentanyl account for the majority of opioid overdose deaths in the United States. Opioid epidemic The sharp rise in overdose deaths from opioids have led many to declare the United States is currently experiencing an opioid epidemic or opioid crisis. The causes of this epidemic are complicated but involve a combination of a rise in dispensed prescriptions, irresponsible marketing from pharmaceutical companies, a lack of physician-patient communication, increased social acceptance of prescription drugs, and an increased supply of cheap and potent heroin on the streets.

West Virginia is currently the state with the highest drug overdose death rate in the United States, with 82 deaths per 100,000 population in 2023. Although West Virginia had the highest drug overdose death rate at that time, California was the state where the most people died from drug overdose. In 2023, around ****** people in California died from a drug overdose. The main perpetrator Opioids account for the majority of all drug overdose deaths in the United States. Opioids include illegal drugs such as heroin, legal prescription drugs like oxycodone, and illicitly manufactured synthetic drugs like fentanyl. The abuse of opioids has increased in recent years, leading to an increased number of drug overdose deaths. The death rate from heroin overdose hit an all-time high of *** per 100,000 population in 2016 and 2017, but has decreased in recent years. Now, illicitly manufactured synthetic opioids such as fentanyl account for the majority of opioid overdose deaths in the United States. Opioid epidemic The sharp rise in overdose deaths from opioids has led many to declare the United States is currently experiencing an opioid epidemic or opioid crisis. The causes of this epidemic are complicated but involve a combination of a rise in dispensed prescriptions, irresponsible marketing from pharmaceutical companies, a lack of physician-patient communication, increased social acceptance of prescription drugs, and an increased supply of cheap and potent heroin on the streets.

In 2023, around 72,776 people in the United States died from a drug overdose that involved fentanyl. This was the second-highest number of fentanyl overdose deaths ever recorded in the United States, and a significant increase from the number of deaths reported in 2019. Fentanyl overdoses are now the driving force behind the opioid epidemic, accounting for the majority of overdose deaths in the United States. What is fentanyl? Fentanyl is an extremely potent synthetic opioid similar to morphine, but more powerful. It is a prescription drug but is also manufactured illegally and is sometimes mixed with other illicit drugs such as heroin and cocaine, often without the user’s knowledge. The potency of fentanyl makes it very addictive and puts users at a high risk for overdose. Illegally manufactured fentanyl has become more prevalent in the United States in recent years, leading to a huge increase in drug overdose deaths. In 2022, the rate of drug overdose death involving fentanyl was 22.7 per 100,000 population, compared to a rate of just one per 100,000 population in the year 2013. Fentanyl overdoses by gender and race/ethnicity As of 2022, the rate of drug overdose deaths involving fentanyl in the United States is over two times higher among men than women. Rates of overdose death involving fentanyl were low for both men and women until around the year 2014 when they began to quickly increase, especially for men. In 2022, there were around 19,880 drug overdose deaths among women that involved fentanyl compared to 53,958 such deaths among men. At that time, the rate of fentanyl overdose deaths was highest among non-Hispanic American Indian or Alaska Natives and lowest among non-Hispanic Asians. However, from the years 2014 to 2018, non-Hispanic whites had the highest fentanyl overdose death rates.

In 2021/2022, the states with the highest share of people who had used cocaine in the past year were Colorado, Vermont, the District of Columbia, Rhode Island and Massachusetts. In Colorado, around 3.06 percent of the population were estimated to have used cocaine in the past year at that time, compared to the U.S. average of 1.95 percent. The states with the lowest past-year cocaine consumption rates were New Hampshire and Wyoming. Cocaine use in the United States As of 2022, cocaine was the second most used illicit drug in the United States, behind marijuana. At that time around 42.2 million people in the U.S. had used cocaine at least once in their lifetime. In comparison, around 29.5 million people reported using LSD in their lifetime and 22.1 million had used ecstasy. In 2022, almost 5.2 million people were estimated to have used cocaine in the past year. How many people in the U.S. die from cocaine every year? The number of drug poisoning deaths involving cocaine has increased significantly over the past couple decades. In 2021, there were around 24,486 overdose deaths involving cocaine, compared to just 3,800 in the year 1999. However, it is important to note that many overdose deaths involving cocaine also involve other drugs, namely opioids. The increase in overdose deaths involving cocaine is directly related to the ongoing opioid epidemic in the United States. Rates of overdose death involving cocaine are twice as high for men than women, but death rates for both men and women have increased in recent years.

Marijuana is by far the most used illicit drug in the United States, with over 61 million people using this drug in 2023. The second most used drug at that time was cocaine, followed by methamphetamine and ecstasy. The United States has had a complicated history with drugs, from fighting a “War on Drugs” starting in the 1970s, to seeing the legalisation of marijuana in many states, and experiencing an ongoing nationwide opioid overdose epidemic. Recreational marijuana Although marijuana is still illegal under federal law, 21 states have legalized the recreational use of marijuana. This legalization has opened a new and thriving market in these states. It is estimated that sales of legal cannabis will reach around 25 billion U.S. dollars by the year 2025. Although support for the legalization of marijuana has not always been strong, now around 68 percent of U.S. adults believe it should be made legal. The opioid epidemic The opioid epidemic describes a rise in overdose deaths in the U.S. due to prescription opioids, heroin, and illegally manufactured synthetic opioids such as fentanyl. The epidemic stems from misleading information from pharmaceutical companies concerning the dangers of opioids such as oxycontin, overprescribing of opioids from physicians, and an influx of easily accessible heroin and highly potent synthetic opioids. In 2022, there were around 81,806 deaths from opioid overdose in the United States.

It is estimated that around *** percent of the global population uses illicit drugs. Use of illicit drugs varies by country and region as countries enact their own laws regarding such substances. Access to illicit drugs also differs by country and region and culture plays a role in how acceptable drug use is. Global drug use Worldwide, cannabis is by far the most used illicit drug, followed by opioids and amphetamines. It is estimated that around *** million people worldwide consume illegal drugs and **** million could be considered addicts or problem drug users. Drug addiction and abuse can negatively impact relationships, increases the risk of a number of diseases, and can ultimately lead to death. Opioid epidemic in the U.S. The United States has a long and complicated history with illegal drugs, once going so far as to fight a “War on Drugs”. Today, the U.S. is experiencing what has been called an opioid epidemic. This has been characterized by an increase in overdose deaths from prescription opioids, heroin and, more recently, illegally manufactured synthetic opioids, such as fentanyl. In 2021, there were ****** opioid overdose deaths in the United States.

In 2023, it was estimated that over ** million people in the United States had used cocaine at some point in their life. The number of people in the United States who stated they had used cocaine in the past month has fluctuated over the past decade, but over *** million people reported they had used cocaine in the past month as of 2023. Cocaine use among teens The percentage of U.S. students in grades *, **, and ** that had used cocaine in their lifetime has gradually decreased since 1999. At that time, around *** percent of students stated they had used cocaine in their lifetime, while in 2021 just *** percent of students said so. Perhaps unsurprisingly, perceived availability of cocaine among **** graders has also decreased over the past couple decades, with about ** percent of **** graders stating cocaine was “fairly easy” or “very easy” to get in 2021, compared to almost ** percent who reported it was easy to get in 1990. The most common illicit drugs U.S. students in grades *, **, and ** reported having used in their lifetime were marijuana, inhalants, and hallucinogens such as LSD and mushrooms. Deaths from cocaine In 2020, there were ****** drug poisoning deaths involving cocaine in the United States. The number of overdose deaths involving cocaine has increased significantly over the past few years as part of the ongoing opioid epidemic. Although, it is possible to die of an overdose just from using cocaine, many overdose deaths in the U.S. that involved cocaine also involved the use of opioids. The rate of overdose deaths involving cocaine is almost ***** times higher among men than women, but both have seen increases in the rate of overdose death in recent years. Considering race and ethnicity, the rate of overdose deaths involving cocaine is by far highest among black, non-Hispanics and lowest among Asian/Pacific Islander, non-Hispanics.

Introduction

New York, NY – January 13, 2025 –  Global Transdermal Patch Market size is expected to be worth around US$ 12.5 Billion by 2033, from US$ 7.9 Billion in 2023, growing at a CAGR of 4.7% during the forecast period from 2024 to 2033. With a market share over 48.2%, North America held a strong lead in 2023, reaching US$ 3.8 Billion in revenue.

The increasing adoption of analgesic patches reflects a shift in pain management practices toward non-invasive and targeted approaches. By delivering painkillers through the skin in a controlled and sustained manner, these patches offer localized therapeutic benefits while minimizing systemic side effects often associated with oral medications. Their ease of use and extended wear time enhance patient compliance, making them a preferred option for managing chronic pain conditions.

Moreover, heightened awareness of the opioid crisis and a growing preference for alternative pain management solutions have significantly bolstered the demand for analgesic patches. As awareness of transdermal drug delivery's benefits expands, analgesic patches are becoming an integral component of modern pain management strategies.

Also it represents a dynamic segment of the pharmaceutical industry, specializing in the design, production, and distribution of drug-delivery patches applied to the skin. These patches provide a non-invasive and convenient alternative to conventional drug administration methods, enabling steady medication release directly into the bloodstream for controlled dosing and extended therapeutic effects.

Market growth is further driven by the rising incidence of chronic diseases such as hypertension, diabetes, and pain-related disorders, coupled with the global increase in the aging population. Technological advancements, including improved adhesives, optimized drug formulations, and innovative delivery mechanisms, are accelerating the adoption of transdermal patches. These innovations not only enhance the efficacy and safety of drug delivery but also contribute to the market's continuous evolution and expansion.

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Naloxone Market Outlook

The global Naloxone market size is projected to grow significantly from USD 1.1 billion in 2023 to an estimated USD 2.6 billion by 2032, reflecting a robust CAGR of 10.2% over the forecast period. This impressive growth is driven by increasing opioid overdose incidents worldwide and the rising awareness of the life-saving potential of Naloxone, an opioid antagonist that can rapidly reverse the effects of opioid overdose.

One of the primary growth factors for the Naloxone market is the alarming rise in opioid-related deaths, which has prompted various governments and health organizations to escalate their response strategies. For instance, the U.S. Food and Drug Administration (FDA) has approved multiple forms of Naloxone administration, including injectable and nasal sprays, making it more accessible to the wider population. Additionally, programs aimed at distributing Naloxone to high-risk individuals and communities have been significantly expanded, further driving the market growth.

Another critical factor contributing to the market expansion is the increasing involvement of non-profit organizations and community groups in providing Naloxone training and distribution. These initiatives are not limited to urban areas but are also penetrating rural and underserved regions, where opioid misuse and overdose rates are particularly high. The educational efforts to train individuals on the use of Naloxone have proven successful, as they have significantly increased the numbers of potential first responders who can administer the drug in emergencies.

Moreover, the regulatory environment supporting the availability of Naloxone has become more favorable over the years. Policies such as the Overdose Prevention Act and various government-funded programs have facilitated easier prescription and over-the-counter availability of Naloxone. This regulatory support is crucial in ensuring that individuals who are at higher risk of opioid overdose, such as chronic pain patients and illicit drug users, can readily access this life-saving medication.

Regionally, North America remains the dominant market for Naloxone, driven primarily by the severe opioid crisis in the United States and Canada. Europe and Asia Pacific are also witnessing an increase in opioid misuse and overdose cases, creating a rising demand for Naloxone. Efforts by international health organizations and local governments to combat the opioid epidemic are expected to spur market growth in these regions as well. The Middle East & Africa and Latin America, while currently lagging in Naloxone usage, are anticipated to see growth due to increasing awareness and improving healthcare infrastructure.

Product Type Analysis

The Naloxone market by product type can be segmented into Injectable, Nasal Spray, and Others. Injectable Naloxone has been a traditional form of administration and continues to hold a significant share of the market. This method is widely used in clinical settings and by emergency medical services (EMS) for its rapid action and reliability. The injectable form is particularly effective in severe overdose cases where immediate intervention is crucial. However, it requires proper training and technique, which can be a limiting factor for its broader use outside medical settings.

Nasal Spray Naloxone has gained considerable traction in recent years due to its ease of use and non-invasive nature. This product type is specifically designed for administration by non-medical personnel, including family members, bystanders, and first responders without medical training. The simplicity of the nasal spray has contributed to its widespread adoption and has been a game-changer in emergency opioid overdose situations. The expanding availability of nasal spray Naloxone over-the-counter in pharmacies has further propelled its growth.

Other forms of Naloxone, including auto-injectors and sublingual tablets, represent a smaller segment of the market but are growing in popularity. Auto-injectors, such as the FDA-approved Evzio, provide voice instructions to guide users through the injection process, making them user-friendly. These alternatives are particularly beneficial for individuals who might be intimidated by traditional syringe-based injections or nasal sprays. The diversification of product types ensures that Naloxone can be tailored to different needs and scenarios, enhancing its overall market penetration.

The market dynamics for each product type are influenced by various factors, including regulator

In 2021, it was estimated that around *** million people worldwide consumed illegal drugs such as cannabis, opioids, and cocaine. Furthermore, around **** million people were thought to be problem drug users or to have a drug use disorder. Although drug use varies from country to country, drug use remains a significant problem in many parts of the world. For example, the United States is currently experiencing an opioid epidemic, with drug overdose deaths reaching record levels over the past few years. What is the most used illicit drug worldwide? The most used illicit drug worldwide is cannabis, followed by opioids, and amphetamines. High estimates suggest that around *** percent of the global population consumed cannabis in the past year as of 2021. In comparison, around *** percent of people were thought to have consumed opioids in the past year, and less than *** percent were estimated to have used amphetamines. Drug use is generally more prevalent among men than women, but this distribution varies by drug. For example, around ** percent of cocaine users worldwide are men and ** percent are women, but women account for ** percent of amphetamine users. Cannabis uses In 2021, it was estimated that around *** million people worldwide consumed cannabis at least once in the past year. The highest number of past year cannabis users at that time was found in the Americas. This may be unsurprising since Canada and many U.S. states now allow the sale and use of recreational cannabis. The market for recreational cannabis is substantial in both countries. In the United States, sales of recreational cannabis reached **** billion U.S. dollars in 2021 and are expected to grow to some ** billion U.S. dollars by the year 2026. In 2020, there were thought to be around **** million adult consumers of cannabis in the United States, with this number expected to increase to just over *** million by 2025.

Snapshot img

Transdermal Patches Market Size 2024-2028

The transdermal patches market size is forecast to increase by USD 2.00 billion at a CAGR of 5.65% between 2023 and 2028. The market is experiencing significant growth due to the increasing demand for non-invasive drug delivery methods. This non-invasive approach offers several advantages, including improved patient compliance, consistent drug delivery, and reduced side effects. Another trend driving market growth is the development of microneedle patches, which enhance drug delivery efficiency by allowing drugs to penetrate deeper into the skin.

However, stringent regulatory approvals for transdermal drug delivery systems by government bodies pose a challenge to market growth. Regulatory agencies require extensive clinical trials and rigorous safety and efficacy testing, which can be time-consuming and costly. Despite these challenges, the market is expected to continue growing due to the numerous benefits offered by transdermal patches over traditional oral and injectable drug delivery methods.

Market Analysis

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Transdermal patches are non-invasive medication delivery systems that provide controlled dosing and prolonged therapeutic effects for various chronic diseases and pain-related conditions. These patches work by delivering medication through the skin directly into the bloodstream, bypassing the digestive system. This method offers several advantages over traditional injections, including reduced healthcare facility costs, improved patient compliance, and fewer medication failures. Technological developments in transdermal patches have led to the creation of electronic and mechanical patches, which offer enhanced features such as real-time monitoring and programmable dosing. Analgesic patches are a common application of transdermal technology, providing effective pain management for conditions such as arthritis and diabetic neuropathy.

The elderly population, who often suffer from multiple chronic diseases, is a significant market for transdermal patches. Chronic diseases such as diabetes, hypertension, and pain-related conditions are major drivers for the growth of the market. The opioid epidemic has also fueled interest in non-invasive pain management methods, further boosting demand for transdermal patches. Adhesives and drug formulations are critical components of transdermal patches, and advancements in these areas are expected to drive innovation in the market. The market for transdermal patches is expected to grow significantly in the coming years, offering opportunities for manufacturers and investors in this space.

Market Segmentation

The market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in 'USD billion' for the period 2024-2028, as well as historical data from 2018-2022 for the following segments.

Application

  Pain management
  Central nervous system disorders
  Hormonal application
  Cardiovascular diseases
  Others


End-user

  Homecare
  Hospitals and clinics


Geography

  North America

    US


  Europe

    Germany
    UK


  Asia

    China
    Japan


  Rest of World (ROW)

By Application Insights

The pain management segment is estimated to witness significant growth during the forecast period. Transdermal patches represent a non-invasive, painless method for medication administration, particularly effective in managing chronic pain conditions. These patches, which deliver analgesic drugs through the skin and into the bloodstream, offer several advantages over traditional injections. Technological developments have led to advancements in adhesive performance, permeability, and skin barriers, ensuring effective drug delivery and minimizing skin irritation. The market for transdermal patches is experiencing growth due to the increasing prevalence of chronic illnesses, such as arthritis, neuropathic pain, and heart disease. Moreover, the opioid epidemic has fueled the demand for alternative, non-addictive pain management techniques. The multi-layer drug-in-adhesive segment is a significant contributor to the market, with various drugs, including opioids, NSAIDs, lidocaine, and antiretroviral drugs for HIV infection, being administered through this technology.

Further, the use of transdermal patches is not limited to pain management; they are also employed in contraceptive applications and for delivering medications to specific body areas, such as the abdomen, buttock, and upper torso, for individuals with a BMI of 30 kg/m2 or higher. The convenience and efficacy of transdermal patches make them an attractive alternative to oral-dosage forms, offering a more consistent dose of medicine and reducing healthcare facility costs.

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The Pain management segment accounted for USD 1.76 billion in 20

As of August 2024, some 20 percent of Americans surveyed were of the opinion that opioids and fentanyl addiction is the number one public health threat in the U.S., a significant decrease from 24 percent in June 2024. Furthermore, obesity was viewed as a top public health issue by 19 percent of Americans in August 2024.
U.S. healthcare issues The United States has the highest healthcare spending globally. The majority of Americans considered rising healthcare costs as the most important healthcare problem facing the U.S. in January 2023. While COVID-19 and cancer were ranked second on the list. Due to unfortunate mass shooting incidents in the country, gun violence is typically related to homicide and is not considered a healthcare issue. Although the most popular method of suicide among Americans who attempted it was a gun or firearm, the link between gun access and suicide is frequently ignored as a public health crisis.

During 2023, there were a total of 8,606 deaths from opioid overdose in Canada, 2,648 of which occurred in the province of Ontario. This statistic shows the number of deaths from opioid overdose in Canada in 2023, by province. Opioid Use and Misuse Opioids are commonly prescribed as both short-term and long-term pain management strategies. Unfortunately, opioids are sometimes used problematically, including taking increased amounts, tampering with the route of administration, or using with the goal to improve mood, all of which can lead to addiction, overdose, and even death. In 2023, there were around 6,462 hospitalizations in Canada due to opioid poisoning. Opioid Crisis in Canada Among Canadian adults, the majority view the opioid issues of the country as a serious problem or a crisis. Moreover, many opioid deaths also involve the use of a stimulant, which adds to the polysubstance nature of the opioid crisis. Efforts against the opioid crisis in Canada are multi-faceted. One way is focused on reducing possible harm from using illicit opioid sources such as heroin or other street opioids through the use of opioid agonist treatment methods including methadone and naloxone.

Austria leads the world in physician density with **** practicing doctors per thousand population in 2022, highlighting significant disparities in healthcare access globally. This stark contrast becomes evident when comparing Austria to countries like India, South Africa, and Indonesia, which have less than * physician per 1,000 people. Life expectancy and healthcare access Interestingly, countries with higher physician densities often correlate with higher life expectancies. Switzerland, for instance, boasts both a high physician density of **** per 1,000 people and the highest life expectancy globally at **** years. This relationship underscores the potential impact of accessible healthcare on population health. However, exceptions exist, as evidenced by the United States, where life expectancy has decreased in recent years despite having **** physicians per 1,000 people. Factors such as the COVID-19 pandemic and the opioid epidemic have contributed to this decline. Healthcare expenditure and physician density While physician density is an important metric, it does not always directly correlate with healthcare spending. The United States, for example, has the highest per capita health expenditure among OECD countries, spending over ****** U.S. dollars per person in 2023. This is significantly higher than countries with greater physician densities like Austria and Germany. The U.S. also allocates the largest share of its GDP to healthcare, at **** percent. The United States is an outlier regarding the correlation between healthcare spending, resources and health outcomes.

This survey displays the share of people in Virginia about what they think is the most important health issue faced in their state, as of April 2022. As much as 38 percent of the survey respondents believed that drug use, the opioid epidemic, or substance abuse are the most important health issue being faced by the people of Virginia.