In 1800, the population of modern day area of South Africa was approximately 1.44 million. Like most of the continent, the population of South Africa increased gradually through most of the 19th century, reaching 4.71 million by the start of the 20th century. Beginning in the 20th century however, the population would begin to rise exponentially as industrialization, advances in medicine and health, and the spread of vaccinations allowed for lower child mortality rates and increased life expectancy among adults. The population of South Africa would continue to rise exponentially for almost a century, going from just under 5 million at the start of the 1900s to almost 45 million by 2000. However, since the early 2000s, South Africa’s population growth has slowed, the result of a significant decrease in fertility rates in the country in recent years. In 2020, South Africa is estimated to have a population of 59.31 million.

The world's population first reached one billion people in 1803, and reach eight billion in 2023, and will peak at almost 11 billion by the end of the century. Although it took thousands of years to reach one billion people, it did so at the beginning of a phenomenon known as the demographic transition; from this point onwards, population growth has skyrocketed, and since the 1960s the population has increased by one billion people every 12 to 15 years. The demographic transition sees a sharp drop in mortality due to factors such as vaccination, sanitation, and improved food supply; the population boom that follows is due to increased survival rates among children and higher life expectancy among the general population; and fertility then drops in response to this population growth. Regional differences The demographic transition is a global phenomenon, but it has taken place at different times across the world. The industrialized countries of Europe and North America were the first to go through this process, followed by some states in the Western Pacific. Latin America's population then began growing at the turn of the 20th century, but the most significant period of global population growth occurred as Asia progressed in the late-1900s. As of the early 21st century, almost two thirds of the world's population live in Asia, although this is set to change significantly in the coming decades. Future growth The growth of Africa's population, particularly in Sub-Saharan Africa, will have the largest impact on global demographics in this century. From 2000 to 2100, it is expected that Africa's population will have increased by a factor of almost five. It overtook Europe in size in the late 1990s, and overtook the Americas a decade later. In contrast to Africa, Europe's population is now in decline, as birth rates are consistently below death rates in many countries, especially in the south and east, resulting in natural population decline. Similarly, the population of the Americas and Asia are expected to go into decline in the second half of this century, and only Oceania's population will still be growing alongside Africa. By 2100, the world's population will have over three billion more than today, with the vast majority of this concentrated in Africa. Demographers predict that climate change is exacerbating many of the challenges that currently hinder progress in Africa, such as political and food instability; if Africa's transition is prolonged, then it may result in further population growth that would place a strain on the region's resources, however, curbing this growth earlier would alleviate some of the pressure created by climate change.

In 1870, the average life expectancy in South Africa was 33.5 years from birth. This life expectancy would remain largely unchanged until the late-1910s, where life expectancy would drop to as low as thirty years as a result of the 1918 Spanish Flu epidemic. In the 1930s, life expectancy in South Africa would begin to steadily rise, peaking at over 63 years in 1995, as industrialization and greater access to healthcare and vaccinations led to significantly reduced child mortality rates across the region. However, life expectancy experienced a sudden drop beginning after 1995, as the HIV/AIDS epidemic spread throughout the country, beginning in the early 1990s. As the epidemic spread through the country, life expectancy would fall by almost 10 years, bottoming out below 54 years in 2005. Life expectancy would begin to rise again beginning in the early 2010s however, as access to HIV counselling and treatments, such as antiretroviral therapy, became more widely available throughout the region. Life expectancy in the country is estimated to be almost 64 years from birth in 2020; a return to the pre-HIV figures of the early 1990s.