How do statistical regression results compare to intuitive, visually fitted results? Fitting lines by eye through a set of points has been explored since the 20th century. Common methods of fitting trends by eye involve maneuvering a string, black thread, or ruler until the fit is suitable, then drawing the line through the set of points. In 2015, the New York Times introduced an interactive feature, called “You Draw It,” where readers were asked to input their own assumptions about various metrics and compare how these assumptions relate to reality. In this article, we validate “You Draw It” as a method for graphical testing, comparing results to the less technological method used in Mosteller et al. and extending that study with formal statistical analysis methods. Results were consistent with those found in the previous study; when shown points following a linear trend, participants tended to fit the slope of the principal axis over the slope of the least-squares regression line. This trend was most prominent when shown data simulated with larger variances. This study reinforces the differences between intuitive visual model fitting and statistical model fitting, providing information about human perception as it relates to the use of statistical graphics. Supplementary materials for this article are available online.

Reconstruction maps of cryo-electron microscopy (cryo-EM) exhibit distortion when the cryo-EM dataset is incomplete, usually caused by unevenly distributed orientations. Prior efforts had been attempted to address this preferred orientation problem using tilt-collection strategy, modifications to grids or to air-water-interfaces. However, these approaches often require time-consuming experiments and the effect was always protein dependent. Here, we developed a procedure containing removing mis-aligned particles and an iterative reconstruction method based on signal-to-noise ratio of Fourier component to correct such distortion by recovering missing data using a purely computational algorithm. This procedure called Signal-to-Noise Ratio Iterative Reconstruction Method (SIRM) was applied on incomplete datasets of various proteins to fix distortion in cryo-EM maps and to a more isotropic resolution. In addition, SIRM provides a better reference map for further reconstruction refinements, resulting in an improved alignment, which ultimately improves map quality and benefits model building.

Laos Exports of other made textile articles, sets, worn clothing was US$5.79 Million during 2023, according to the United Nations COMTRADE database on international trade. Laos Exports of other made textile articles, sets, worn clothing - data, historical chart and statistics - was last updated on November of 2025.

Sweden Imports of Miscellanneous manufactured articles was US$446.38 Million during 2024, according to the United Nations COMTRADE database on international trade. Sweden Imports of Miscellanneous manufactured articles - data, historical chart and statistics - was last updated on December of 2025.

Bitcoin is the first implementation of a technology that has become known as a 'public permissionless' blockchain. Such systems allow public read/write access to an append-only blockchain database without the need for any mediating central authority. Instead they guarantee access, security and protocol conformity through an elegant combination of cryptographic assurances and game theoretic economic incentives. Not until the advent of the Bitcoin blockchain has such a trusted, transparent, comprehensive and granular data set of digital economic behaviours been available for public network analysis. In this article, by translating the cumbersome binary data structure of the Bitcoin blockchain into a high fidelity graph model, we demonstrate through various analyses the often overlooked social and econometric benefits of employing such a novel open data architecture. Specifically we show (a) how repeated patterns of transaction behaviours can be revealed to link user activity across t...

Additional file 1. 32 root disease categories from MONDO.

United States Imports of Articles of iron or steel was US$52.65 Billion during 2024, according to the United Nations COMTRADE database on international trade. United States Imports of Articles of iron or steel - data, historical chart and statistics - was last updated on December of 2025.

Denmark Exports of other articles of plastics to Kazakhstan was US$466.07 Thousand during 2024, according to the United Nations COMTRADE database on international trade. Denmark Exports of other articles of plastics to Kazakhstan - data, historical chart and statistics - was last updated on December of 2025.

Russia Exports of articles of iron or steel was US$3.97 Billion during 2021, according to the United Nations COMTRADE database on international trade. Russia Exports of articles of iron or steel - data, historical chart and statistics - was last updated on December of 2025.

Costa Rica Imports from Vietnam of Other Articles of Glass was US$2.29 Thousand during 2023, according to the United Nations COMTRADE database on international trade. Costa Rica Imports from Vietnam of Other Articles of Glass - data, historical chart and statistics - was last updated on November of 2025.

Vietnam Imports from United States of Articles of Natural Cork was US$621 during 2017, according to the United Nations COMTRADE database on international trade. Vietnam Imports from United States of Articles of Natural Cork - data, historical chart and statistics - was last updated on November of 2025.

United States Imports from Georgia of Other Articles of Plastics was US$1.07 Million during 2024, according to the United Nations COMTRADE database on international trade. United States Imports from Georgia of Other Articles of Plastics - data, historical chart and statistics - was last updated on November of 2025.

Egypt Exports of other made textile articles, sets, worn clothing was US$254.87 Million during 2024, according to the United Nations COMTRADE database on international trade. Egypt Exports of other made textile articles, sets, worn clothing - data, historical chart and statistics - was last updated on November of 2025.

Jordan Imports of Articles of iron or steel was US$222.67 Million during 2023, according to the United Nations COMTRADE database on international trade. Jordan Imports of Articles of iron or steel - data, historical chart and statistics - was last updated on December of 2025.

Honduras Imports from China of Articles of iron or steel was US$90.06 Million during 2024, according to the United Nations COMTRADE database on international trade. Honduras Imports from China of Articles of iron or steel - data, historical chart and statistics - was last updated on November of 2025.

United States Imports from Greenland of Miscellanneous manufactured articles was US$13.35 Thousand during 2013, according to the United Nations COMTRADE database on international trade. United States Imports from Greenland of Miscellanneous manufactured articles - data, historical chart and statistics - was last updated on December of 2025.

Cameroon Imports from Spain of Other Articles of Glass was US$1.59 Thousand during 2023, according to the United Nations COMTRADE database on international trade. Cameroon Imports from Spain of Other Articles of Glass - data, historical chart and statistics - was last updated on December of 2025.

Guatemala Exports of articles of iron or steel to Suriname was US$100 during 2023, according to the United Nations COMTRADE database on international trade. Guatemala Exports of articles of iron or steel to Suriname - data, historical chart and statistics - was last updated on November of 2025.

United States Exports of miscellanneous manufactured articles to Colombia was US$20.79 Million during 2024, according to the United Nations COMTRADE database on international trade. United States Exports of miscellanneous manufactured articles to Colombia - data, historical chart and statistics - was last updated on November of 2025.

United States Imports from Cameroon of Other Articles of Wood was US$2.55 Thousand during 2024, according to the United Nations COMTRADE database on international trade. United States Imports from Cameroon of Other Articles of Wood - data, historical chart and statistics - was last updated on November of 2025.