reallbunnyboo/syx dataset hosted on Hugging Face and contributed by the HF Datasets community

Global Industrial reported $171.2M in Stock for its fiscal quarter ending in June of 2025. Data for Global Industrial | SYX - Stock including historical, tables and charts were last updated by Trading Economics this last October in 2025.

SYntaXin 3 Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in positive regulation of defecation and regulation of muscle contraction. Located in plasma membrane. syx-3 encodes a syntaxin (t-SNARE) homologous to mammalian and Drosophila syntaxin 1; by homology, SYX-3 is a predicted plasma membrane protein that mediates fusion events between exocytic vesicles and the plasma membrane.

BackgroundRnd3 (RhoE) protein belongs to the unique branch of Rho family GTPases that has low intrinsic GTPase activity and consequently remains constitutively active [1], [2]. The current consensus is that Rnd1 and Rnd3 function as important antagonists of RhoA signaling primarily by activating the ubiquitous p190 RhoGAP [3], but not by inhibiting the ROCK family kinases.Methodology/Principal FindingsRnd3 is abundant in mouse embryonic stem (mES) cells and in an unbiased two-step affinity purification screen we identified a new Rnd3 target, termed synectin-binding RhoA exchange factor (Syx), by mass spectrometry. The Syx interaction with Rnd3 does not occur through the Syx DH domain but utilizes a region similar to the classic Raf1 Ras-binding domain (RBD), and most closely related to those in RGS12 and RGS14. We show that Syx behaves as a genuine effector of Rnd3 (and perhaps Rnd1), with binding characteristics similar to p190-RhoGAP. Morpholino-oligonucleotide knockdown of Syx in zebrafish at the one cell stage resulted in embryos with shortened anterior-posterior body axis: this phenotype was effectively rescued by introducing mouse Syx1b mRNA. A Rnd3-binding defective mutant of Syx1b mutated in the RBD (E164A/R165D) was more potent in rescuing the embryonic defects than wild-type Syx1b, showing that Rnd3 negatively regulates Syx activity in vivo.Conclusions/SignificanceThis study uncovers a well defined Rnd3 effector Syx which is widely expressed and directly impacts RhoA activation. Experiments conducted in vivo indicate that Rnd3 negatively regulates Syx, and that as a RhoA-GEF it plays a key role in early embryonic cell shape changes. Thus a connection to signaling via the planar cell polarity pathway is suggested.

Protein-Protein, Genetic, and Chemical Interactions for SYX-5 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: SYntaXin

SYntaXin 17 Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in synaptic vesicle. Orthologous to human STX17 (syntaxin 17). Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in autophagosome membrane; endomembrane system; and plasma membrane. Predicted to be part of SNARE complex. Is an ortholog of human STX17 (syntaxin 17).

Protein-Protein, Genetic, and Chemical Interactions for SYX-16 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: SYntaXin

Global Industrial reported $400K in Ordinary Share Capital for its fiscal quarter ending in March of 2025. Data for Global Industrial | SYX - Ordinary Share Capital including historical, tables and charts were last updated by Trading Economics this last October in 2025.

SYntaXin 5 Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; synaptic vesicle docking; and vesicle fusion. Predicted to be located in Golgi apparatus; membrane; and presynapse. Predicted to be part of SNARE complex. Predicted to be active in Golgi membrane. Is expressed in several structures, including anal depressor muscle; excretory gland cell; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). syx-5 is an ortholog of human STX5 (syntaxin 5); syx-5 is involved in apoptotic process, embryo development, hermaphrodite genitalia development, locomotion, nematode larval development, positive regulation of growth, receptor-mediated endocytosis, reproduction and secretion by cell; syx-5 is expressed in the pharynx, anal depressor muscle, nervous system, reproductive system, excretory gland cell, and the body wall musculature; at the sub-cellular level, SYX-5::GFP shows a punctate pattern in the epidermis that could correspond to the Golgi apparatus, in addition to a faint pattern highly reminiscent of adherens junctions.

SYntaXin 6 Predicted to enable SNAP receptor activity. Predicted to be involved in synaptic vesicle docking. Located in Golgi trans cisterna. Is expressed in several structures, including anal sphincter muscle; hypodermis; intestine; nervous system; and pharynx. Orthologous to several human genes including STX10 (syntaxin 10). Predicted to be involved in synaptic vesicle docking. Located in Golgi trans cisterna. Expressed in head. Is an ortholog of human STX10 (syntaxin 10).

Global Industrial reported $1.33B in Market Capitalization this October of 2025, considering the latest stock price and the number of outstanding shares.Data for Global Industrial | SYX - Market Capitalization including historical, tables and charts were last updated by Trading Economics this last October in 2025.

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Syntaxin 16 Enables SNAP receptor activity. Involved in Golgi vesicle transport. Located in Golgi trans cisterna; lysosome; and membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type 1B. Orthologous to human STX16 (syntaxin 16). Syntaxin 16 (Syx16) encodes a member of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family. It is localized to late Golgi compartments and is part of a trans-SNARE complex responsible for endosome-to-Golgi/trans Golgi network retrograde transport.

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Protein-Protein, Genetic, and Chemical Interactions for SYX-17 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: SYntaXin