30 datasets found
  1. e

    Tuberculosis data

    • data.europa.eu
    excel xlsx, html, pdf
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    European Centre for Disease Prevention and Control, Tuberculosis data [Dataset]. https://data.europa.eu/data/datasets/tuberculosis-data?locale=en
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    pdf, excel xlsx, htmlAvailable download formats
    Dataset authored and provided by
    European Centre for Disease Prevention and Control
    License

    http://data.europa.eu/eli/dec/2011/833/ojhttp://data.europa.eu/eli/dec/2011/833/oj

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Attribution-NonCommercial-NoDerivs 4.0 (CC BY-NC-ND 4.0)https://creativecommons.org/licenses/by-nc-nd/4.0/
    License information was derived automatically

    Description

    The dataset provides surveillance and disease data for tuberculosis.

  2. A

    CDC WONDER: Online Tuberculosis Information System (OTIS)

    • data.amerigeoss.org
    • data.virginia.gov
    • +5more
    query tool
    Updated Jul 26, 2019
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    United States[old] (2019). CDC WONDER: Online Tuberculosis Information System (OTIS) [Dataset]. https://data.amerigeoss.org/sr/dataset/cdc-wonder-online-tuberculosis-information-system-otis-2e0f5
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    query toolAvailable download formats
    Dataset updated
    Jul 26, 2019
    Dataset provided by
    United States[old]
    Description

    The Online Tuberculosis Information System (OTIS) on CDC WONDER contains information on verified tuberculosis (TB) cases reported to the Centers for Disease Control and Prevention (CDC) by state health departments, the District of Columbia and Puerto Rico since 1993. These data were extracted from the CDC national TB surveillance system. OTIS reports case counts, incidence rates, population counts, percentage of cases that completed therapy within 1 year of diagnosis, and percentage of cases tested for drug susceptibility. Data for 22 variables are included in the data set, including: age groups, race / ethnicity, sex, vital status, year reported, state, metropolitan area, several patient risk factors, directly observed therapy, disease verification criteria and multi-drug resistant TB. Each year these data are updated with an additional year of cases plus revisions to cases reported in previous years. OTIS is produced by the U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), National Center for HIV/AIDS, viral Hepatitis, STD and TB Prevention (NCHHSTP).

  3. o

    County Hwy Tb Cross Street Data in Richland Center, WI

    • ownerly.com
    Updated Jan 18, 2022
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    Ownerly (2022). County Hwy Tb Cross Street Data in Richland Center, WI [Dataset]. https://www.ownerly.com/wi/richland-center/county-hwy-tb-home-details
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    Dataset updated
    Jan 18, 2022
    Dataset authored and provided by
    Ownerly
    Area covered
    Wisconsin, Richland Center, County Highway Tb
    Description

    This dataset provides information about the number of properties, residents, and average property values for County Hwy Tb cross streets in Richland Center, WI.

  4. Tuberculosis prevalence (2015)

    • hub.arcgis.com
    • esri-ea.hub.arcgis.com
    Updated Aug 8, 2016
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    Esri Eastern Africa Mapping and Application Portal (2016). Tuberculosis prevalence (2015) [Dataset]. https://hub.arcgis.com/datasets/Esri-EA::tuberculosis-prevalence-2015/data
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    Dataset updated
    Aug 8, 2016
    Dataset provided by
    Esrihttp://esri.com/
    Authors
    Esri Eastern Africa Mapping and Application Portal
    Area covered
    Description

    The number of cases of tuberculosis (all forms) in a population at a given point in time (the middle of the calendar year), expressed as the rate per 100 000 population. Estimates include cases of TB in people with HIV.Tuberculosis is considered as one of the three pandemics of low- and middle- income countries.

  5. a

    Indicator 3.3.2 Tuberculosis incidence per 100,000 population.

    • sdg-en-psaqatar.opendata.arcgis.com
    • hub.arcgis.com
    Updated Dec 5, 2024
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    National Planning Council (2024). Indicator 3.3.2 Tuberculosis incidence per 100,000 population. [Dataset]. https://sdg-en-psaqatar.opendata.arcgis.com/items/76e023ddae9c435990f047f2a855391b
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    Dataset updated
    Dec 5, 2024
    Dataset authored and provided by
    National Planning Council
    Description

    Indicator 3.3.2Tuberculosis incidence per 100,000 population.Methodology:Incidence rate=(Number of new and relapse TB cases / Mid-year population) * 100 000.Data Source:Ministry of Public Health - Accounts of the National Planning Council.

  6. NNDSS - Table II. Tuberculosis

    • data.cdc.gov
    • healthdata.gov
    • +1more
    Updated Oct 11, 2019
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    Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (2019). NNDSS - Table II. Tuberculosis [Dataset]. https://data.cdc.gov/NNDSS/NNDSS-Table-II-Tuberculosis/5avu-ff58
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    application/rdfxml, csv, application/rssxml, tsv, xml, kml, application/geo+json, kmzAvailable download formats
    Dataset updated
    Oct 11, 2019
    Dataset provided by
    National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
    Authors
    Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
    Description

    NNDSS - Table II. Tuberculosis - 2019. This Table includes total number of cases reported in the United States, by region and by states, in accordance with the current method of displaying WONDER data. Data on United States will exclude counts from US territories. Footnote: C.N.M.I.: Commonwealth of Northern Mariana Islands. U: Unavailable. -: No reported cases. N: Not reportable. NN: Not Nationally Notifiable Cum: Cumulative year-to-date counts. Min: Minimum. Max: Maximum. * Case counts for reporting year 2018 and 2019 are provisional and subject to change. For further information on interpretation of these data, see http://wwwn.cdc.gov/nndss/document/ProvisionalNationaNotifiableDiseasesSurveillanceData20100927.pdf † Data for TB are displayed quarterly.

  7. g

    SDG 3.3.2, Tuberculosis Incidences per 100000 Population, Administrative...

    • irelandsdg.geohive.ie
    • ga.geohive.ie
    • +2more
    Updated Nov 7, 2017
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    Sustainable Development Goals, Ireland (2017). SDG 3.3.2, Tuberculosis Incidences per 100000 Population, Administrative County, 2014, Ireland, HPSC, CSO & Tailte Éireann [Dataset]. https://irelandsdg.geohive.ie/datasets/30b89e906ec94426baa3e3fdeb56079b
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    Dataset updated
    Nov 7, 2017
    Dataset authored and provided by
    Sustainable Development Goals, Ireland
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Area covered
    Description

    This feature layer represents Sustainable Development Goal indicator 3.3.2 'Tuberculosis Incidents per 100000 Population' for Ireland. The layer was created using National TB Surveillance data, 2014 produced by the Health Protection Surveillance Centre and pre 2014 Administrative County boundary data (more info) produced by Tailte Éireann. In 2015 UN countries adopted a set of 17 goals to end poverty, protect the planet and ensure prosperity for all as part of a new sustainable development agenda. Each goal has specific targets to help achieve the goals set out in the agenda by 2030. Governments are committed to establishing national frameworks for the achievement of the 17 Goals and to review progress using accessible quality data. With these goals in mind the Central Statistics Office (CSO) and Tailte Éireann are working together to link geography and statistics to produce indicators that help communicate and monitor Ireland’s performance in relation to achieving the 17 sustainable development goals.The indicator displayed supports the efforts to achieve goal number 3 which aims to ensure healthy lives and promote well-being for all at all ages.

  8. g

    Inspire data set BPL “Construction plan city center- An der Stadtbahn 3. TB...

    • gimi9.com
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    Inspire data set BPL “Construction plan city center- An der Stadtbahn 3. TB Wohnen” [Dataset]. https://gimi9.com/dataset/eu_aee61f29-fce1-4b30-a3f9-5a66295152ba
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    License

    CC0 1.0 Universal Public Domain Dedicationhttps://creativecommons.org/publicdomain/zero/1.0/
    License information was derived automatically

    Description

    According to INSPIRE transformed development plan “Construction plan city center- An der Stadtbahn 3. TB Wohnen” of the city of Gaggenau based on an XPlanung dataset in version 5.0.

  9. A

    GEO logo white tb 1500 1

    • data.amerigeoss.org
    • sdgs.amerigeoss.org
    • +3more
    Updated Feb 26, 2019
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    AmeriGEOSS (2019). GEO logo white tb 1500 1 [Dataset]. https://data.amerigeoss.org/tr/dataset/geo-logo-white-tb-1500-12
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    arcgis geoservices rest api, htmlAvailable download formats
    Dataset updated
    Feb 26, 2019
    Dataset provided by
    AmeriGEOSS
    Description

    This is the GEO Logo - Note it is transparent so you won't be able to see a thumbnail!!!!!


    GEO Logo

  10. f

    Data from: S1 Data -

    • plos.figshare.com
    bin
    Updated May 21, 2024
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    Kedija Hayre; Mihiretu Kumie Takele; Dagim Jirata Birri (2024). S1 Data - [Dataset]. http://doi.org/10.1371/journal.pone.0303797.s001
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    binAvailable download formats
    Dataset updated
    May 21, 2024
    Dataset provided by
    PLOS ONE
    Authors
    Kedija Hayre; Mihiretu Kumie Takele; Dagim Jirata Birri
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    BackgroundTuberculosis (TB) is a global public health problem. Evaluation of TB treatment outcome enables health institutions to measure and improve the effectiveness of TB control programs. This study aimed to assess treatment outcomes of tuberculosis and identify associated factors among TB patients registered at Alemgena Health Center, Oromia, Ethiopia.MethodA retrospective study was conducted; Secondary data were collected from medical records of 1010 TB patients treated at Alemgena Health Center between September 2012 and August 2018, inclusively. Logistic regression was used to identify factors associated with TB treatment outcomes. P-value less than 0.05 was considered statistically significant.ResultsThe proportion of males and females was almost equal. Among the patients 64.7% were in the age group 15–34, 98% were new cases, 31.2% were smear positive, 13% were HIV positive and 40.3% had extra-pulmonary tuberculosis. 94.2% of the patients had successful treatment outcome, with 26.9% cured and 67.3% treatment completed, whereas 5.8% had unsuccessful treatment outcomes, of whom 4.2% died and 1.5% defaulted. Death rate was higher among patients older than 44 years (10.4%) than among children (0%). In bivariate logistic regression analysis, treatment success rate was 3.582 (95% CI 1.958–6.554, p-value = .000) times higher in the age group 44 and below compared to the age group 45 and above.ConclusionTreatment success rate exceeded the one targeted by WHO. Age was found to be associated with treatment outcome. Success rate has to be improved for TB patients in the age group greater than 45 years of age.

  11. T

    Taiwan CREI: Office Rent Concession Index: Taipei City Grade B (TB)

    • ceicdata.com
    Updated Feb 15, 2025
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    Taiwan CREI: Office Rent Concession Index: Taipei City Grade B (TB) [Dataset]. https://www.ceicdata.com/en/taiwan/office-rent-index-and-vacancy-rate-taiwan-real-estate-research-center-cathay-real-estate-development-company-ltd/crei-office-rent-concession-index-taipei-city-grade-b-tb
    Explore at:
    Dataset updated
    Feb 15, 2025
    Dataset provided by
    CEICdata.com
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Time period covered
    Mar 1, 2008 - Dec 1, 2010
    Area covered
    Taiwan
    Variables measured
    Rent
    Description

    Taiwan CREI: Office Rent Concession Index: Taipei City Grade B (TB) data was reported at 90.000 2006-2008=100 in Dec 2010. This records a decrease from the previous number of 92.000 2006-2008=100 for Sep 2010. Taiwan CREI: Office Rent Concession Index: Taipei City Grade B (TB) data is updated quarterly, averaging 97.000 2006-2008=100 from Mar 2008 (Median) to Dec 2010, with 12 observations. The data reached an all-time high of 102.000 2006-2008=100 in Dec 2008 and a record low of 90.000 2006-2008=100 in Dec 2010. Taiwan CREI: Office Rent Concession Index: Taipei City Grade B (TB) data remains active status in CEIC and is reported by Taiwan Real Estate Research Center. The data is categorized under Global Database’s Taiwan – Table TW.EB027: Office Rent Index and Vacancy Rate: Taiwan Real Estate Research Center, Cathay Real Estate Development Company Ltd.

  12. g

    Inspire data set BPL “Construction plan city center- An der Stadtbahn 4. TB...

    • gimi9.com
    + more versions
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    Inspire data set BPL “Construction plan city center- An der Stadtbahn 4. TB Wohnen” [Dataset]. https://gimi9.com/dataset/eu_2581a48c-18a9-48c7-9f90-5eab720efe28
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    License

    CC0 1.0 Universal Public Domain Dedicationhttps://creativecommons.org/publicdomain/zero/1.0/
    License information was derived automatically

    Description

    According to INSPIRE transformed development plan “Construction plan city center- An der Stadtbahn 4. TB Wohnen” of the city of Gaggenau based on an XPlanung dataset in version 5.0.

  13. d

    Meteorological Archival Facility.

    • datadiscoverystudio.org
    • data.wu.ac.at
    pdf
    Updated Mar 8, 2017
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    (2017). Meteorological Archival Facility. [Dataset]. http://datadiscoverystudio.org/geoportal/rest/metadata/item/a5359e08cc5c47b0aea277f3f66284ba/html
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    pdfAvailable download formats
    Dataset updated
    Mar 8, 2017
    Description

    description: FUNCTION: The Bergen Data Center (BDC) provides data archival capability for meteorological and oceanographic data.DESCRIPTION: The BDC operates as a resource for researchers, visiting scientists, and collaborators to access meteorological and oceanographic data. From its initial capacity of 31 TB in 1998, the BDC has grown to its present capacity of 271 TB. It accomodates diverse research requirements, providing archiving of critical data.INSTRUMENTATION: The facility includes a server, SAN switch, tape library, and tape drives. The server, tape library, and tape drives are linked together by Cisco Systems MDS 9216 SAN switch and Cisco Systems MDS 9509 SAN director. The Dell PowerEdge 2850 with the RedHat Enterprise Linux operating system runs Veritas Netbackup Enterprise software for backup, archiving, and tape library management. The tape library has 678 tape slots and 6 tape drives each having a direct connection to the SAN. BDC has a data transfer rate of 1.5 TB per hour. The total online tape storage capacity is 271 TB.; abstract: FUNCTION: The Bergen Data Center (BDC) provides data archival capability for meteorological and oceanographic data.DESCRIPTION: The BDC operates as a resource for researchers, visiting scientists, and collaborators to access meteorological and oceanographic data. From its initial capacity of 31 TB in 1998, the BDC has grown to its present capacity of 271 TB. It accomodates diverse research requirements, providing archiving of critical data.INSTRUMENTATION: The facility includes a server, SAN switch, tape library, and tape drives. The server, tape library, and tape drives are linked together by Cisco Systems MDS 9216 SAN switch and Cisco Systems MDS 9509 SAN director. The Dell PowerEdge 2850 with the RedHat Enterprise Linux operating system runs Veritas Netbackup Enterprise software for backup, archiving, and tape library management. The tape library has 678 tape slots and 6 tape drives each having a direct connection to the SAN. BDC has a data transfer rate of 1.5 TB per hour. The total online tape storage capacity is 271 TB.

  14. T

    Taiwan CREI: Office Listing Rent Index: TB: Dunbei & Minsheng Road

    • ceicdata.com
    + more versions
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    CEICdata.com, Taiwan CREI: Office Listing Rent Index: TB: Dunbei & Minsheng Road [Dataset]. https://www.ceicdata.com/en/taiwan/office-rent-index-and-vacancy-rate-taiwan-real-estate-research-center-cathay-real-estate-development-company-ltd/crei-office-listing-rent-index-tb-dunbei--minsheng-road
    Explore at:
    Dataset provided by
    CEICdata.com
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Time period covered
    Dec 1, 2008 - Dec 1, 2010
    Area covered
    Taiwan
    Variables measured
    Rent
    Description

    Taiwan CREI: Office Listing Rent Index: TB: Dunbei & Minsheng Road data was reported at 97.000 2006-2008=100 in Dec 2010. This records a decrease from the previous number of 98.000 2006-2008=100 for Sep 2010. Taiwan CREI: Office Listing Rent Index: TB: Dunbei & Minsheng Road data is updated quarterly, averaging 101.000 2006-2008=100 from Dec 2008 (Median) to Dec 2010, with 9 observations. The data reached an all-time high of 104.000 2006-2008=100 in Mar 2009 and a record low of 97.000 2006-2008=100 in Dec 2010. Taiwan CREI: Office Listing Rent Index: TB: Dunbei & Minsheng Road data remains active status in CEIC and is reported by Taiwan Real Estate Research Center. The data is categorized under Global Database’s Taiwan – Table TW.EB027: Office Rent Index and Vacancy Rate: Taiwan Real Estate Research Center, Cathay Real Estate Development Company Ltd.

  15. f

    FGD for TB suspected patients.

    • plos.figshare.com
    xls
    Updated Jun 1, 2023
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    Sujan Babu Marahatta; Rajesh Kumar Yadav; Deena Giri; Sarina Lama; Komal Raj Rijal; Shiva Raj Mishra; Ashish Shrestha; Pramod Raj Bhattrai; Roshan Kumar Mahato; Bipin Adhikari (2023). FGD for TB suspected patients. [Dataset]. http://doi.org/10.1371/journal.pone.0227293.t006
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    xlsAvailable download formats
    Dataset updated
    Jun 1, 2023
    Dataset provided by
    PLOS ONE
    Authors
    Sujan Babu Marahatta; Rajesh Kumar Yadav; Deena Giri; Sarina Lama; Komal Raj Rijal; Shiva Raj Mishra; Ashish Shrestha; Pramod Raj Bhattrai; Roshan Kumar Mahato; Bipin Adhikari
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    FGD for TB suspected patients.

  16. T

    Taiwan CREI: Office Rent Concession Index: TB: Minsheng & Jianguo Road

    • ceicdata.com
    + more versions
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    CEICdata.com, Taiwan CREI: Office Rent Concession Index: TB: Minsheng & Jianguo Road [Dataset]. https://www.ceicdata.com/en/taiwan/office-rent-index-and-vacancy-rate-taiwan-real-estate-research-center-cathay-real-estate-development-company-ltd/crei-office-rent-concession-index-tb-minsheng--jianguo-road
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    Dataset provided by
    CEICdata.com
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Time period covered
    Dec 1, 2008 - Dec 1, 2010
    Area covered
    Taiwan
    Variables measured
    Rent
    Description

    Taiwan CREI: Office Rent Concession Index: TB: Minsheng & Jianguo Road data was reported at 81.000 2006-2008=100 in Dec 2010. This stayed constant from the previous number of 81.000 2006-2008=100 for Sep 2010. Taiwan CREI: Office Rent Concession Index: TB: Minsheng & Jianguo Road data is updated quarterly, averaging 87.000 2006-2008=100 from Dec 2008 (Median) to Dec 2010, with 9 observations. The data reached an all-time high of 104.000 2006-2008=100 in Dec 2008 and a record low of 81.000 2006-2008=100 in Dec 2010. Taiwan CREI: Office Rent Concession Index: TB: Minsheng & Jianguo Road data remains active status in CEIC and is reported by Taiwan Real Estate Research Center. The data is categorized under Global Database’s Taiwan – Table TW.EB027: Office Rent Index and Vacancy Rate: Taiwan Real Estate Research Center, Cathay Real Estate Development Company Ltd.

  17. f

    Data from: S1 Dataset -

    • plos.figshare.com
    xlsx
    Updated Feb 12, 2025
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    Lukundo Siame; Gift C. Chama; Sepiso K. Masenga (2025). S1 Dataset - [Dataset]. http://doi.org/10.1371/journal.pone.0312570.s002
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    xlsxAvailable download formats
    Dataset updated
    Feb 12, 2025
    Dataset provided by
    PLOS ONE
    Authors
    Lukundo Siame; Gift C. Chama; Sepiso K. Masenga
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    BackgroundTuberculosis (TB) remains a significant public health challenge, particularly among vulnerable populations like children. This is especially true in Sub-Saharan Africa, where the burden of TB in children is substantial. Zambia ranks 21st among the top 30 high TB endemic countries globally. While studies have explored TB in adults in Zambia, the prevalence and associated factors in children are not well documented. This study aimed to determine the prevalence and sociodemographic, and clinical factors associated with active TB disease in hospitalized children under the age of 15 years at Livingstone University Teaching Hospital (LUTH), the largest referral center in Zambia’s Southern Province.MethodsThis retrospective cross-sectional study of 700 pediatric patients under 15 years old, utilized programmatic data from the Pediatrics Department at LUTH. A systematic sampling method was used to select participants from medical records. Data on demographics, medical conditions, anthropometric measurements, and blood tests were collected. Data analysis included descriptive statistics, chi-square tests, and multivariable logistic regression to identify factors associated with TB.ResultsThe median age was 24 months (interquartile range (IQR): 11, 60) and majority were male (56.7%, n = 397/700). Most participants were from urban areas (59.9%, n = 419/700), and 9.2% (n = 62/675) were living with HIV. Malnutrition and comorbidities were present in a significant portion of the participants (19.0% and 25.1%, respectively). The prevalence of active TB cases was 9.4% (n = 66/700) among hospitalized children. Persons living with HIV (Adjusted odds ratio (AOR) of 6.30; 95% confidence interval (CI) of 2.85, 13.89, p< 0.001), and those who were malnourished (AOR: 10.38, 95% CI: 4.78, 22.55, p< 0.001) had a significantly higher likelihood of developing active TB disease.ConclusionThis study revealed a prevalence 9.4% active TB among hospitalized children under 15 years at LUTH. HIV status and malnutrition emerged as significant factors associated with active TB disease. These findings emphasize the need for pediatric TB control strategies that prioritize addressing associated factors to effectively reduce the burden of tuberculosis in Zambian children.

  18. T

    Taiwan CREI: Office Rent Concession Index: TB: Nanjing & Guangfu Road

    • ceicdata.com
    + more versions
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    CEICdata.com, Taiwan CREI: Office Rent Concession Index: TB: Nanjing & Guangfu Road [Dataset]. https://www.ceicdata.com/en/taiwan/office-rent-index-and-vacancy-rate-taiwan-real-estate-research-center-cathay-real-estate-development-company-ltd/crei-office-rent-concession-index-tb-nanjing--guangfu-road
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    Dataset provided by
    CEICdata.com
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Time period covered
    Dec 1, 2008 - Dec 1, 2010
    Area covered
    Taiwan
    Variables measured
    Rent
    Description

    Taiwan CREI: Office Rent Concession Index: TB: Nanjing & Guangfu Road data was reported at 98.000 2006-2008=100 in Dec 2010. This stayed constant from the previous number of 98.000 2006-2008=100 for Sep 2010. Taiwan CREI: Office Rent Concession Index: TB: Nanjing & Guangfu Road data is updated quarterly, averaging 98.000 2006-2008=100 from Dec 2008 (Median) to Dec 2010, with 9 observations. The data reached an all-time high of 114.000 2006-2008=100 in Sep 2009 and a record low of 96.000 2006-2008=100 in Dec 2009. Taiwan CREI: Office Rent Concession Index: TB: Nanjing & Guangfu Road data remains active status in CEIC and is reported by Taiwan Real Estate Research Center. The data is categorized under Global Database’s Taiwan – Table TW.EB027: Office Rent Index and Vacancy Rate: Taiwan Real Estate Research Center, Cathay Real Estate Development Company Ltd.

  19. f

    DataSheet_1_Classification of tuberculosis-related programmed cell...

    • frontiersin.figshare.com
    zip
    Updated Jun 2, 2023
    + more versions
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    Jie Shen; Chao Zhao; Hong Zhang; Peipei Zhou; Zhenpeng Li (2023). DataSheet_1_Classification of tuberculosis-related programmed cell death-related patient subgroups and associated immune cell profiling.zip [Dataset]. http://doi.org/10.3389/fimmu.2023.1159713.s001
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    zipAvailable download formats
    Dataset updated
    Jun 2, 2023
    Dataset provided by
    Frontiers
    Authors
    Jie Shen; Chao Zhao; Hong Zhang; Peipei Zhou; Zhenpeng Li
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    BackgroundTuberculosis (TB) is the deadliest communicable disease in the world with the exception of the ongoing COVID-19 pandemic. Programmed cell death (PCD) patterns play key roles in the development and progression of many disease states such that they may offer value as effective biomarkers or therapeutic targets that can aid in identifying and treating TB patients.Materials and methodsThe Gene Expression Omnibus (GEO) was used to gather TB-related datasets after which immune cell profiles in these data were analyzed to examine the potential TB-related loss of immune homeostasis. Profiling of differentially expressed PCD-related genes was performed, after which candidate hub PCD-associated genes were selected via a machine learning approach. TB patients were then stratified into two subsets based on the expression of PCD-related genes via consensus clustering. The potential roles of these PCD-associated genes in other TB-related diseases were further examined.ResultsIn total, 14 PCD-related differentially expressed genes (DEGs) were identified and highly expressed in TB patient samples and significantly correlated with the abundance of many immune cell types. Machine learning algorithms enabled the selection of seven hub PCD-related genes that were used to establish PCD-associated patient subgroups, followed by the validation of these subgroups in independent datasets. These findings, together with GSVA results, indicated that immune-related pathways were significantly enriched in TB patients exhibiting high levels of PCD-related gene expression, whereas metabolic pathways were significantly enriched in the other patient group. Single cell RNA-seq (scRNA-seq) further highlighted significant differences in the immune status of these different TB patient samples. Furthermore, we used CMap to predict five potential drugs for TB-related diseases.ConclusionThese results highlight clear enrichment of PCD-related gene expression in TB patients and suggest that this PCD activity is closely associated with immune cell abundance. This thus indicates that PCD may play a role in TB progression through the induction or dysregulation of an immune response. These findings provide a foundation for further research aimed at clarifying the molecular drivers of TB, the selection of appropriate diagnostic biomarkers, and the design of novel therapeutic interventions aimed at treating this deadly infectious disease.

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    Parameters considered in the TB vaccine clinical trial centre directory:...

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    xls
    Updated Oct 28, 2024
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    Parameters considered in the TB vaccine clinical trial centre directory: Centre characteristics, type of disease targets, intervention expertise and capacity, TB vaccine. [Dataset]. https://plos.figshare.com/articles/dataset/Parameters_considered_in_the_TB_vaccine_clinical_trial_centre_directory_Centre_characteristics_type_of_disease_targets_intervention_expertise_and_capacity_TB_vaccine_/27317614
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    Dataset updated
    Oct 28, 2024
    Dataset provided by
    PLOS ONE
    Authors
    Puck T. Pelzer; Marit Holleman; Michelle E. H. Helinski; Ana Lucia Weinberg; Joeri Buis; Pauline Beattie; Thomas Nyirenda; Job van Rest; Gerald Voss
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    Parameters considered in the TB vaccine clinical trial centre directory: Centre characteristics, type of disease targets, intervention expertise and capacity, TB vaccine.

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European Centre for Disease Prevention and Control, Tuberculosis data [Dataset]. https://data.europa.eu/data/datasets/tuberculosis-data?locale=en

Tuberculosis data

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pdf, excel xlsx, htmlAvailable download formats
Dataset authored and provided by
European Centre for Disease Prevention and Control
License

http://data.europa.eu/eli/dec/2011/833/ojhttp://data.europa.eu/eli/dec/2011/833/oj

Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
License information was derived automatically

Attribution-NonCommercial-NoDerivs 4.0 (CC BY-NC-ND 4.0)https://creativecommons.org/licenses/by-nc-nd/4.0/
License information was derived automatically

Description

The dataset provides surveillance and disease data for tuberculosis.

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