In 2022, there were 565 reported deaths due to tuberculosis, a significant decrease from 5,217 deaths in 1970. This statistic depicts the number of deaths due to tuberculosis in the United States from 1960 to 2022. Tuberculosis Disease Of all infectious diseases, tuberculosis (TB) remains one of the most deadly worldwide. TB is a contagious lung disease caused by bacteria and passed through the air from an infected person to others. It often remains dormant for a few years before presenting as an active case in about five percent of latent cases. Common symptoms include coughing, including coughing up blood, and unexplained weight loss as the infection begins to spread throughout the body. Without antibiotic treatment, about one third of those with an active infection will die within two years and another third within five years. At-risk Populations Although the death rate for TB in the United States and other developed countries has remained relatively low over the past thirty years, other countries are more heavily burdened by this disease. The regions of Africa and South-East Asia have the highest number of tuberculosis deaths worldwide. In 2022, there were around 632 thousand deaths due to tuberculosis in South-East Asia, compared to just 35 thousand in the Americas.

In 2023, there were around 1.25 million deaths due to tuberculosis worldwide. This statistic shows the number of tuberculosis deaths worldwide from 2010 to 2023.

In 2023, there were around 15.5 deaths due to tuberculosis per 100,000 population worldwide. In comparison, the tuberculosis mortality rate in the year 2010 was 28.4 per 100,000 population. This statistic shows the mortality rate of tuberculosis worldwide from 2010 to 2023.

The leading causes of death in the United States have changed significantly from the year 1900 to the present. Leading causes of death in 1900, such as tuberculosis, gastrointestinal infections, and diphtheria have seen huge decreases in death rates and are no longer among the leading causes of death in the United States. However, other diseases such as heart disease and cancer have seen increased death rates. Vaccinations One major factor contributing to the decrease in death rates for many diseases since the year 1900 is the introduction of vaccinations. The decrease seen in the rates of death due to pneumonia and influenza is a prime example of this. In 1900, pneumonia and influenza were the leading causes of death, with around *** deaths per 100,000 population. However, in 2023 pneumonia and influenza were not even among the ten leading causes of death. Cancer One disease that has seen a large increase in death rates since 1900 is cancer. Cancer currently accounts for almost ** percent of all deaths in the United States, with death rates among men higher than those for women. The deadliest form of cancer for both men and women is cancer of the lung and bronchus. Some of the most common avoidable risk factors for cancer include smoking, drinking alcohol, sun exposure, and obesity.

We collected county-level cumulative COVID-19 confirmed cases and death from Mar 25 to Nov 12, 2020, across the contiguous United States from USAFacts (usafacts.org). We considered Mar 25 to Jun 3 as the “1st wave”, Jun 4 to Sep 2 as the “2nd wave”, and Sep 3 to Nov 12 as the “3rd wave” of COVID-19. For the 2nd and 3rd waves, we analyzed the targeted counties in the sunbelt region (including AL, AZ, AR, CA, FL, GA, KS, LA, MS, NV, NM, NC, OK, SC, TX, TN, and UT states) and great plains region (including IA, IL, IN, KS, MI, MO, MN, ND, NE, OH, SD, and WI states), respectively. MIR, as a proxy for survival rate, is calculated by dividing the number of confirmed deaths in each county by the confirmed cases in the same county at the same time-period multiplied by 100. MIR ranges from 0%-100%, 100% indicating the worst situation where all confirmed cases have died.

Thirty-eight potential risk factors (covariates), including county-level MR of comorbidities & disorders, demographics & social factors, and environmental factors, were retrieved from the University of Washington Global Health Data Exchange (http://ghdx.healthdata.org/us-data). Comorbidities and disorders include CVD, cardiomyopathy and myocarditis and myocarditis, hypertensive heart disease, peripheral vascular disease, atrial fibrillation, cerebrovascular disease, diabetes, hepatitis, HIV/AIDS, tuberculosis (TB), lower respiratory infection, interstitial lung disease and pulmonary sarcoidosis, asthma, COPD, ischemia, mesothelioma, tracheal cancer, leukemia, pancreatic cancer, rheumatic disease, drug use disorder, and alcohol use disorder. Demographics & social factors include age, female African American%, female white American%, male African American%, male white American%, Asian%, smokers%, unemployed%, income rate, food insecurity, fair/poor health, and uninsured%. Environmental factors include county population density, air quality index (AQI), temperature, and PM. A descriptive table, including all potential risk factors, is provided in Table S1).

Tuberculosis is one of the deadliest communicable diseases worldwide, causing around *** million deaths per year. Communicable diseases, also known as infectious diseases, are spread from person to person either directly or indirectly, such as through an insect bite or ingesting contaminated food or water. Some of the deadliest communicable diseases include HIV/AIDS, malaria, hepatitis C, cholera, and measles. Tuberculosis Tuberculosis is an infectious disease that affects the lungs. Tuberculosis disproportionately impacts the poorer, less developed countries of the world, such as in Africa and Southeast Asia. India reports the highest number of deaths from tuberculosis worldwide. HIV/AIDS Although deaths from HIV/AIDS have decreased over the last few decades, there were still around ******* AIDS-related deaths in 2023. Like many other communicable diseases, HIV/AIDS impacts developing regions more than the developed world. By far, the highest number of AIDS deaths come from Africa and Asia Pacific. Advancements in HIV treatment now allow those infected to live long and relatively normal lives, but access to treatment varies greatly.

The data shows the statistics of different item-wise reports at the facility on a cumulative yearly basis in different states up to the sub-district level of the year 2020-21.it included: 1) Ante Natal Care (ANC) - Antenatal care (ANC) is a means to identify high-risk pregnancies and educate women so that they might experience healthier delivery and outcomes. 2) Deliveries - The delivery of the baby by the pregnant women 3) Number of Caesarean (C-Section) deliveries - Caesarean delivery (C-section) is used to deliver a baby through surgical incisions made in the abdomen and uterus. 4) Pregnancy outcome & details of new-born - The records kept of the pregnancy outcome along with the details of new-born 5) Complicated Pregnancies - The different pregnancies that were not normal and had complications 6) Post Natal Care (PNC) - Postnatal care is defined as care given to the mother and her new-born baby immediately after the birth of the placenta and for the first six weeks of life 7) Reproductive Tract Infections/Sexually Transmitted Infections (RTI/STI) Cases - The records of reproductive tract infections along with the records of the sexually transmitted cases 8) Family Planning - The different methods used by families to keep the track of family 9) CHILD IMMUNISATION - The records of child immunisation which are records of vaccination 10) Number of cases of Childhood Diseases (0-5 years) - The records of the number of cases of childhood diseases within the age of 5 years old 11) NVBDCP - The National Vector Borne Disease Control Programme (NVBDCP) is one of the most comprehensive and multi-faceted public health activities in the country and concerned with the prevention and control of vector-borne diseases namely Malaria, Filariasis, Kala-azar, Dengue and Japanese Encephalitis (JE). 12) Adolescent Health - The record of the conditions of adolescent health 13 ) Directly Observed Treatment, Short-course (DOTS) - Directly observed treatment, short-course (DOTS, also known as TB-DOTS) is the name given to the tuberculosis (TB) control strategy recommended by the World Health Organization 14) Patient Services - Patient Services means those which vary with the number of personnel; professional and para-professional skills of the personnel; specialized equipment, and reflect the intensity of the medical and psycho-social needs of the patients. 15) Laboratory Testing - A medical procedure that involves testing a sample of blood, urine, or other substance from the body. Laboratory tests can help determine a diagnosis, plan treatment, check to see if treatment is working, or monitor the disease over time. 16) Details of deaths reported with probable causes - The reports of deaths recorded with possible causes are given in a detail 17) Vaccines - The reports of vaccines which are recorded 18) Syringes - It is the number of syringes that are used and recorded 19) Rashtriya Bal Swasthaya Karyakram (RBSK) - Rashtriya Bal Swasthya Karyakram (RBSK) is an important initiative aiming at early identification and early intervention for children from birth to 18 years to cover 4 'D's viz. Defects at birth, Deficiencies, Diseases, Development delays including disability. 20) Coverage under WIFS JUNIOR - The coverage of the Weekly Iron Folic Acid Supplementation Programme for children six to one 21) Maternal Death Reviews (MDR) - A maternal death review is the cross-checking of how the mother died. It provides a rare opportunity for a group of health staff and community members to learn from a tragic – and often preventable. 22) Janani Shishu Suraksha Karyakaram (JSSK)- It is an initiative to provide completely free and cashless services to pregnant women including normal deliveries and caesarean operations. It entitles all pregnant women delivering in public health institutions to absolutely free and no expense delivery, including caesarean section.

According to preliminary data between January and October 2024, *** percent of deaths in the Philippines were caused by respiratory tuberculosis diseases. Deaths from such illnesses gradually declined, with its lowest share recorded in 2021. However, from that year onwards, the share of deaths from this illness slowly increased.

In 2018, the total estimated TB-HIV mortality rate in India was reported to be ************ cases. Since 2000, the rate of total TB-HIV related mortality has gradually declined. The highest incidence was seen in 2001 with *** thousand reported cases.

In 2023, there were approximately 821,200 tuberculosis cases reported in Indonesia, indicating a significant increase compared to the previous year. Tuberculosis is more prevalent among Indonesian men than women.