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This statistic shows the number of packs of TGI Friday's frozen hot snacks eaten within one month in the United States in 2020. The data has been calculated by Statista based on the U.S. Census data and Simmons National Consumer Survey (NHCS). According to this statistic, **** million Americans consumed * packs or more in 2020.

The top ten target genes of transcription factor AHR predicted by KGE-TGI model.

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Protein-Protein, Genetic, and Chemical Interactions for TGI (Drosophila melanogaster) curated by BioGRID (https://thebiogrid.org); DEFINITION: Tondu-domain-containing Growth Inhibitor

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Infections early in life can have enduring effects on an organism’s development and immunity. In this study, we show that this equally applies to developing “superorganisms” – incipient social insect colonies. When we exposed newly mated Lasius niger ant queens to a low pathogen dose, their colonies grew more slowly than controls before winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation survival improved when the ratio of pupae to workers was small. Queens that reared fewer pupae before worker emergence exhibited lower pathogen levels, indicating that high brood rearing efforts interfere with the ability of the queen’s immune system to suppress pathogen proliferation. Early-life queen pathogen-exposure also improved the immunocompetence of her worker offspring, as demonstrated by challenging the workers to the same pathogen a year later. Transgenerational transfer of the queen’s pathogen experience to her workforce can hence durably reduce the disease susceptibility of the whole superorganism.

Methods All experimental procedures are described in the main manuscript text or supplemental material. Data collectors: Barbara Casillas-PÈrez, Christopher D. Pull, Elisabeth Naderlinger

Tondu-domain-containing Growth Inhibitor Enables DNA-binding transcription factor binding activity and transcription coactivator binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Orthologous to human VGLL4 (vestigial like family member 4). Tondu-domain-containing Growth Inhibitor (Tgi) encodes a protein that interacts with both components of the sd-yki transcriptional complex to inhibit its activity and thus restrict tissue growth.

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Protein-Protein, Genetic, and Chemical Interactions for Vissers JHA (2020):Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi. curated by BioGRID (https://thebiogrid.org); ABSTRACT: The Hippo pathway is an evolutionarily conserved signaling network that regulates organ size, cell fate, and tumorigenesis. In the context of organ size control, the pathway incorporates a large variety of cellular cues, such as cell polarity and adhesion, into an integrated transcriptional response. The central Hippo signaling effector is the transcriptional coactivator Yorkie, which controls gene expression in partnership with different transcription factors, most notably Scalloped. When it is not activated by Yorkie, Scalloped can act as a repressor of transcription, at least in part due to its interaction with the corepressor protein Tgi. The mechanism by which Tgi represses transcription is incompletely understood, and therefore we sought to identify proteins that potentially operate together with Tgi. Using an affinity purification and mass-spectrometry approach we identified Pits and CtBP as Tgi-interacting proteins, both of which have been linked to transcriptional repression. Both Pits and CtBP were required for Tgi to suppress the growth of the Drosophila melanogaster eye and CtBP loss suppressed the undergrowth of yorkie mutant eye tissue. Furthermore, as reported previously for Tgi, overexpression of Pits repressed transcription of Hippo pathway target genes. These findings suggest that Tgi might operate together with Pits and CtBP to repress transcription of genes that normally promote tissue growth. The human orthologs of Tgi, CtBP, and Pits (VGLL4, CTBP2, and IRF2BP2) have previously been shown to physically and functionally interact to control transcription, implying that the mechanism by which these proteins control transcriptional repression is conserved throughout evolution.

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Prediction performance of KGE-TGI model using different datasets in 5-fold cross validation.

Prediction performance of KGE-TGI with different embedding size.

Prediction performance of KGE-TGI in K-fold cross-validation.

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Triumph reported $357.32M in Stock for its fiscal quarter ending in March of 2025. Data for Triumph | TGI - Stock including historical, tables and charts were last updated by Trading Economics this last December in 2025.