It is estimated that the largest cities in Western Europe in 1330 were Paris and Granada. At this time, Paris was the seat of power in northern France, while Granada had become the largest multicultural city in southern Spain, controlled by the Muslim, Nasrid Kingdom during Spain's Reconquista period. The next three largest cities were Venice, Genoa and Milan, all in northern Italy, renowned as important trading cities during the middle ages. In October 1347, the first wave of the Black Death had arrived in Sicily and then began spreading throughout Europe, decimating the population.

It is estimated that the cities of Cordova (modern-day Córdoba) and Palermo were the largest cities in Europe in 1050, and had between fifteen and twenty times the population of most other entries in this graph, Despite this the cities of Cordova (the capital city of the Umayyad caliphate, who controlled much of the Iberian peninsula from the seventh to eleventh centuries), and Palermo (another Arab-controlled capital in Southern Europe) were still the only cities in Western Europe with a population over one hundred thousand people, closely followed by Seville. It is also noteworthy to point out that the five largest cities on this list were importing trading cities, in modern day Spain or Italy, although the largest cities become more northern and western European in later lists (1200, 1330, 1500, 1650 and 1800). In 1050, todays largest Western European cities, London and Paris, had just twenty-five and twenty thousand inhabitants respectively.

The period of European history (and much of world history) between 500 and 1500 is today known as the 'Dark Ages'. Although the term 'Dark Ages' was originally applied to the lack of literature and arts, it has since been applied to the lack or scarcity of recorded information from this time. Because of these limitations, much information about this time is still being debated today.

Throughout the early modern period, the largest city in Italy was Naples. The middle ages saw many metropolitan areas along the Mediterranean grow to become the largest in Europe, as they developed into meeting ports for merchants travelling between the three continents. Italy, throughout this time, was not a unified country, but rather a collection of smaller states that had many cultural similarities, and political control of these cities regularly shifted over the given period. Across this time, the population of each city generally grew between each century, but a series of plague outbreaks in the 1600s devastated the populations of Italy's metropolitan areas, which can be observed here. Naples At the beginning of the 1500s, the Kingdom of Naples was taken under the control of the Spanish crown, where its capital grew to become the largest city in the newly-expanding Spanish Empire. Prosperity then grew in the 16th and 17th centuries, before the city's international importance declined in the 18th century. There is also a noticeable dip in Naples' population size between 1600 and 1700, due to an outbreak of plague in 1656 that almost halved the population. Today, Naples is just the third largest city in Italy, behind Rome and Milan. Rome Over 2,000 years ago, Rome became the first city in the world to have a population of more than one million people, and in 2021, it was Italy's largest city with a population of 2.8 million; however it did go through a period of great decline in the middle ages. After the Fall of the Western Roman Empire in 476CE, Rome's population dropped rapidly, below 100,000 inhabitants in 500CE. 1,000 years later, Rome was an important city in Europe as it was the seat of the Catholic Church, and it had a powerful banking sector, but its population was just 55,000 people as it did not have the same appeal for merchants or migrants held by the other port cities. A series of reforms by the Papacy in the late-1500s then saw significant improvements to infrastructure, housing, and sanitation, and living standards rose greatly. Over the following centuries, the Papacy consolidated its power in the center of the Italian peninsula, which brought stability to the region, and the city of Rome became a cultural center. Across this period, Rome's population grew almost three times larger, which was the highest level of growth of these cities.

In the year 1500, the share of Western Europe's population living in urban areas was just six percent, but this rose to 31 percent by the end of the 19th century. Despite this drastic change, development was quite slow between 1500 and 1800, and it was not until the industrial revolution when there was a spike in urbanization. As Britain was the first region to undergo the industrial revolution, from around the 1760s until the 1840s, these areas were the most urbanized in Europe by 1890. The Low Countries Prior to the 19th century, Belgium and the Netherlands had been the most urbanized regions due to the legacy of their proto-industrial areas in the medieval period, and then the growth of their port cities during the Netherlands' empirical expansion (Belgium was a part of the Netherlands until the 1830s). Belgium was also quick to industrialize in the 1800s, and saw faster development than its larger, more economically powerful neighbors, France and Germany. Least-urban areas Ireland was the only Western European region with virtually no urbanization in the 16th and 17th century, but the industrial growth of Belfast and Dublin (then major port cities of the British Empire) saw this change by the late-1800s. The region of Scandinavia was the least-urbanized area in Western Europe by 1890, but it saw rapid economic growth in Europe during the first half of the following century.

The Black Death was the largest and deadliest pandemic of Yersinia pestis recorded in human history, and likely the most infamous individual pandemic ever documented. The plague originated in the Eurasian Steppes, before moving with Mongol hordes to the Black Sea, where it was then brought by Italian merchants to the Mediterranean. From here, the Black Death then spread to almost all corners of Europe, the Middle East, and North Africa. While it was never endemic to these regions, it was constantly re-introduced via trade routes from Asia (such as the Silk Road), and plague was present in Western Europe until the seventeenth century, and the other regions until the nineteenth century. Impact on Europe In Europe, the major port cities and metropolitan areas were hit the hardest. The plague spread through south-western Europe, following the arrival of Italian galleys in Sicily, Genoa, Venice, and Marseilles, at the beginning of 1347. It is claimed that Venice, Florence, and Siena lost up to two thirds of their total population during epidemic's peak, while London, which was hit in 1348, is said to have lost at least half of its population. The plague then made its way around the west of Europe, and arrived in Germany and Scandinavia in 1348, before travelling along the Baltic coast to Russia by 1351 (although data relating to the death tolls east of Germany is scarce). Some areas of Europe remained untouched by the plague for decades; for example, plague did not arrive in Iceland until 1402, however it swept across the island with devastating effect, causing the population to drop from 120,000 to 40,000 within two years. Reliability While the Black Death affected three continents, there is little recorded evidence of its impact outside of Southern or Western Europe. In Europe, however, many sources conflict and contrast with one another, often giving death tolls exceeding the estimated population at the time (such as London, where the death toll is said to be three times larger than the total population). Therefore, the precise death tolls remain uncertain, and any figures given should be treated tentatively.

It is estimated that Europe had an urbanization rate of approximately 8.5 percent in the year 1800. The Netherlands and Belgium were some of the most heavily urbanized regions, due the growth of port cities such as Rotterdam and Antwerp during Netherlands' empirical expansion, and the legacy of urbanization in the region, which stems from its wool and craft industries in medieval times. Additionally, the decline of their agricultural sectors and smaller territories contributed to a lower rural population. Scotland and England had also become more urban throughout the British Empire's growth, although the agricultural revolution of the previous two centuries, along with the first industrial revolution, then led to more rapid urbanization during the 19th century. In contrast, there was a large imbalance between the east and west of the continent; the two largest empires, Austria and Russia, had the lowest levels of urbanization in Europe in 1800, due to their vast territories, lower maritime presence, and lack of industrial development.