TOXLINE was the National Library of Medicine (NLM) bibliographic database for toxicology, a varied science encompassing many disciplines. TOXLINE records provide bibliographic information covering the biochemical, pharmacological, physiological, and toxicological effects of drugs and other chemicals. TOXLINE references were drawn from various sources organized into component subfiles. This version of TOXLINE is no longer updated. Updated TOXLINE content is available in PubMed or by searching PubMed using the search string: tox [sb] .

TOXNET is a group of databases hosted by the National Library of Medicine containing factual information related to the toxicity and other hazards of chemicals. They are structured around chemical records.

 There are four basic groupings of TOXNET databases. Within each of these
 groupings are one or more databases. The first grouping is Toxicology Data
 including factual information on toxicity and other hazards of chemicals. The
 databases included in Toxicology Databases are the following four - Hazardous
 Substances Data Bank (HSDB) providing broad scope in human and animal toxicity,
 safety and handling, environmental fate, and more. Scientifically
 peer-reviewed; the Integrated Risk Information System (IRIS) providing Data
 from the Environmental Protection Agency (EPA) in support of human health risk
 assessment. It, focuses on identifying hazards and assessing the connection
 between dose and response; Chemical Carcinogenesis Research Information System
 (CCRIS) providing carcinogenicity, mutagenicity, tumor promotion, and tumor
 inhibition data provided by the National Cancer Institute (NCI) and GENE-TOX
 providing peer-reviewed mutagenicity test data from the EPA.

 The second grouping is Toxicology Literature. These TOXNET databases contain
 bibliographic information with citations to the scientific literature. You can
 use this information to locate the article in a journal. Many provide
 hyperlinks to Medical Subject Headings (MESH) and other keywords. The
 databases included in Toxicology Literature are the following three - TOXLINE,
 providing an extensive array of references to literature on biochemical,
 pharmacological, physiological, and toxicological effects of drugs and other
 chemicals; Environmental Mutagen Information Center (EMIC) providing current
 and older literature on agents tested for genotoxic activity and Developmental
 and Reproductive Toxicology (DART) and Environmental Teratology Information
 Center (ETIC) providing current and older literature on developmental and
 reproductive toxicology.

 The third grouping is the Toxic Release Information which includes just The
 Toxics Release Inventory (TRI) database created by the Environmental Protection
 Agency and contains data on the estimated quantities of chemicals released to
 the environment or transferred off-site for waste treatment. TRI also holds
 information related to source reduction and recycling. Data for the most recent
 and two prior reporting years is currently available. This particular TRI
 database includes the years 1995 to 1999.

 The fourth grouping is Chemical Information. Chemicals are identified in a
 number of ways, including by name and structural diagram. Using a dictionary or
 a thesaurus can help you find information for a particular substance. SIS
 maintains several chemical online resources to help you determine the identity
 of a substance and point you to files or resources of interest. There are three
 databases within this grouping. The first is ChemIDplus providing Numerous
 chemical synonyms, structures, regulatory list information, and links to other
 databases containing information about the chemicals; HSDB Structures providing
 2D and 3D structural information on the HSDB chemicals and NCI-3D providing 2D
 and 3Dstructural information on compounds tested for anti-tumor activity
 compiled by the National Cancer Institute.

 The TOXNET Basic Search screens are intuitive and straightforward. Most screens
 (except for the TRI database) allow you to place all query information in a
 single input box. For example, you may be looking for a chemical name, a
 particular author, a CAS Registry Number, or any type of concept term. You may
 enter any combination of these into the single input box. In some databases,
 you may also limit your search by author, title or dates.

Toxicology data file of the National Library of Medicine''s (NLM) Toxicology Data Network (TOXNET). It is a scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). It contains over 9,000 chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primary journals, current awareness tools, NCI reports, and other special sources. Test results have been reviewed by experts in carcinogenesis and mutagenesis. CCRIS is easily accessible and free of charge. Users can search by chemical or other name, chemical name fragment, Chemical Abstracts Service Registry Number (RN), and/or subject terms. Search results can easily be viewed, printed or downloaded. Search results are displayed in relevancy ranked order. Users may select to display any combination of data from the following broad groupings: (a) Carcinogenicity Studies (b) Tumor Promotion Studies (c) Mutagenicity Studies (d) Tumor Inhibition Studies Users can easily conduct their CCRIS search strategy against other databases: Hazardous Substances Data Bank, Integrated Risk Information System, GENE-TOX, TOXLINE, and ChemIDplus.