From the mid-19th century until today, life expectancy at birth in the United States has roughly doubled, from 39.4 years in 1850 to 79.6 years in 2025. It is estimated that life expectancy in the U.S. began its upward trajectory in the 1880s, largely driven by the decline in infant and child mortality through factors such as vaccination programs, antibiotics, and other healthcare advancements. Improved food security and access to clean water, as well as general increases in living standards (such as better housing, education, and increased safety) also contributed to a rise in life expectancy across all age brackets. There were notable dips in life expectancy; with an eight year drop during the American Civil War in the 1860s, a seven year drop during the Spanish Flu empidemic in 1918, and a 2.5 year drop during the Covid-19 pandemic. There were also notable plateaus (and minor decreases) not due to major historical events, such as that of the 2010s, which has been attributed to a combination of factors such as unhealthy lifestyles, poor access to healthcare, poverty, and increased suicide rates, among others. However, despite the rate of progress slowing since the 1950s, most decades do see a general increase in the long term, and current UN projections predict that life expectancy at birth in the U.S. will increase by another nine years before the end of the century.

A global phenomenon, known as the demographic transition, has seen life expectancy from birth increase rapidly over the past two centuries. In pre-industrial societies, the average life expectancy was around 24 years, and it is believed that this was the case throughout most of history, and in all regions. The demographic transition then began in the industrial societies of Europe, North America, and the West Pacific around the turn of the 19th century, and life expectancy rose accordingly. Latin America was the next region to follow, before Africa and most Asian populations saw their life expectancy rise throughout the 20th century.

Life expectancy in the United Kingdom was below 39 years in the year 1765, and over the course of the next two and a half centuries, it is expected to have increased by more than double, to 81.1 by the year 2020. Although life expectancy has generally increased throughout the UK's history, there were several times where the rate deviated from its previous trajectory. These changes were the result of smallpox epidemics in the late eighteenth and early nineteenth centuries, new sanitary and medical advancements throughout time (such as compulsory vaccination), and the First world War and Spanish Flu epidemic in the 1910s.

Life expectancy in Russia was 29.6 in the year 1845, and over the course of the next 175 years, it is expected to have increased to 72.3 years by 2020. Generally speaking, Russian life expectancy has increased over this 175 year period, however events such as the World Wars, Russian Revolution and a series of famines caused fluctuations before the mid-twentieth century, where the rate fluctuated sporadically. Between 1945 and 1950, Russian life expectancy more than doubled in this five year period, and it then proceeded to increase until the 1970s, when it then began to fall again. Between 1970 and 2005, the number fell from 68.5 to 65, before it then grew again in more recent years.

Life expectancy in India was 25.4 in the year 1800, and over the course of the next 220 years, it has increased to almost 70. Between 1800 and 1920, life expectancy in India remained in the mid to low twenties, with the largest declines coming in the 1870s and 1910s; this was because of the Great Famine of 1876-1878, and the Spanish Flu Pandemic of 1918-1919, both of which were responsible for the deaths of up to six and seventeen million Indians respectively; as well as the presence of other endemic diseases in the region, such as smallpox. From 1920 onwards, India's life expectancy has consistently increased, but it is still below the global average.

Life expectancy in Canada was just below forty in the year 1800, and over the course of the next 220 years, it is expected to have increased by more than double to 82.2 by the year 2020. Throughout this time, life expectancy in Canada progressed at a steady rate, with the most noticeable changes coming during the interwar period, where the rate of increase was affected by the Spanish Flu epidemic and both World Wars.

The child mortality rate in the United States, for children under the age of five, was 462.9 deaths per thousand births in 1800. This means that for every thousand babies born in 1800, over 46 percent did not make it to their fifth birthday. Over the course of the next 220 years, this number has dropped drastically, and the rate has dropped to its lowest point ever in 2020 where it is just seven deaths per thousand births. Although the child mortality rate has decreased greatly over this 220 year period, there were two occasions where it increased; in the 1870s, as a result of the fourth cholera pandemic, smallpox outbreaks, and yellow fever, and in the late 1910s, due to the Spanish Flu pandemic.