In 2021, the leading causes of death in lower-middle income countries worldwide were COVID-19, ischemic heart disease, and stroke. That year, COVID-19 resulted in around 3.94 million deaths in lower-middle income countries, over a million more deaths than ischemic heart disease, the second leading cause of death for countries in this income group. This statistic displays the number of deaths for the leading causes of death in lower-middle income countries in 2021.

In 2021, the leading causes of death in lower-middle income countries worldwide were COVID-19, ischemic heart disease, and stroke. That year, the death rate for COVID-19 in lower-middle income countries was around 131 per 100,000 population. This statistic displays the rates of death for the leading causes of death in lower-middle income countries in 2021.