Analysis of ‘🎗️ Cancer Rates by U.S. State’ provided by Analyst-2 (analyst-2.ai), based on source dataset retrieved from https://www.kaggle.com/yamqwe/cancer-rates-by-u-s-statee on 13 February 2022.

--- Dataset description provided by original source is as follows ---

About this dataset

In the following maps, the U.S. states are divided into groups based on the rates at which people developed or died from cancer in 2013, the most recent year for which incidence data are available.

The rates are the numbers out of 100,000 people who developed or died from cancer each year.

Incidence Rates by State
The number of people who get cancer is called cancer incidence. In the United States, the rate of getting cancer varies from state to state.

• *Rates are per 100,000 and are age-adjusted to the 2000 U.S. standard population.

• ‡Rates are not shown if the state did not meet USCS publication criteria or if the state did not submit data to CDC.

• †Source: U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2013 Incidence and Mortality Web-based Report. Atlanta (GA): Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute; 2016. Available at: http://www.cdc.gov/uscs.

Death Rates by State
Rates of dying from cancer also vary from state to state.

• *Rates are per 100,000 and are age-adjusted to the 2000 U.S. standard population.

• †Source: U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2013 Incidence and Mortality Web-based Report. Atlanta (GA): Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute; 2016. Available at: http://www.cdc.gov/uscs.

Source: https://www.cdc.gov/cancer/dcpc/data/state.htm

This dataset was created by Adam Helsinger and contains around 100 samples along with Range, Rate, technical information and other features such as: - Range - Rate - and more.

How to use this dataset

• Analyze Range in relation to Rate
• Study the influence of Range on Rate
• More datasets

Acknowledgements

If you use this dataset in your research, please credit Adam Helsinger

Start A New Notebook!

--- Original source retains full ownership of the source dataset ---

The number of new cases, age-standardized rates and average age at diagnosis of cancers diagnosed annually from 1992 to the most recent diagnosis year available. Included are all invasive cancers and in situ bladder cancer with cases defined using the Surveillance, Epidemiology and End Results (SEER) Groups for Primary Site based on the World Health Organization International Classification of Diseases for Oncology, Third Edition (ICD-O-3). Cancer incidence rates are age-standardized using the direct method and the final 2011 Canadian postcensal population structure. Random rounding of case counts to the nearest multiple of 5 is used to prevent inappropriate disclosure of health-related information.

Cancer Mortality & Incidence Rates: (Country LVL)

Investigating Cancer Trends over time

By Data Exercises [source]

About this dataset

This dataset is a comprehensive collection of data from county-level cancer mortality and incidence rates in the United States between 2000-2014. This data provides an unprecedented level of detail into cancer cases, deaths, and trends at a local level. The included columns include County, FIPS, age-adjusted death rate, average death rate per year, recent trend (2) in death rates, recent 5-year trend (2) in death rates and average annual count for each county. This dataset can be used to provide deep insight into the patterns and effects of cancer on communities as well as help inform policy decisions related to mitigating risk factors or increasing preventive measures such as screenings. With this comprehensive set of records from across the United States over 15 years, you will be able to make informed decisions regarding individual patient care or policy development within your own community!

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For more datasets, click here.

Featured Notebooks

• 🚨 Your notebook can be here! 🚨!

How to use the dataset

This dataset provides comprehensive US county-level cancer mortality and incidence rates from 2000 to 2014. It includes the mortality and incidence rate for each county, as well as whether the county met the objective of 45.5 deaths per 100,000 people. It also provides information on recent trends in death rates and average annual counts of cases over the five year period studied.

This dataset can be extremely useful to researchers looking to study trends in cancer death rates across counties. By using this data, researchers will be able to gain valuable insight into how different counties are performing in terms of providing treatment and prevention services for cancer patients and whether preventative measures and healthcare access are having an effect on reducing cancer mortality rates over time. This data can also be used to inform policy makers about counties needing more target prevention efforts or additional resources for providing better healthcare access within at risk communities.

When using this dataset, it is important to pay close attention to any qualitative columns such as “Recent Trend” or “Recent 5-Year Trend (2)” that may provide insights into long term changes that may not be readily apparent when using quantitative variables such as age-adjusted death rate or average deaths per year over shorter periods of time like one year or five years respectively. Additionally, when studying differences between different counties it is important to take note of any standard FIPS code differences that may indicate that data was collected by a different source with a difference methodology than what was used in other areas studied

Research Ideas

• Using this dataset, we can identify patterns in cancer mortality and incidence rates that are statistically significant to create treatment regimens or preventive measures specifically targeting those areas.
• This data can be useful for policymakers to target areas with elevated cancer mortality and incidence rates so they can allocate financial resources to these areas more efficiently.
• This dataset can be used to investigate which factors (such as pollution levels, access to medical care, genetic make up) may have an influence on the cancer mortality and incidence rates in different US counties

Acknowledgements

If you use this dataset in your research, please credit the original authors. Data Source

License

License: Dataset copyright by authors - You are free to: - Share - copy and redistribute the material in any medium or format for any purpose, even commercially. - Adapt - remix, transform, and build upon the material for any purpose, even commercially. - You must: - Give appropriate credit - Provide a link to the license, and indicate if changes were made. - ShareAlike - You must distribute your contributions under the same license as the original. - Keep intact - all notices that refer to this license, including copyright notices.

Columns

File: death .csv | Column name | Description | |:-------------------------------------------|:-------------------------------------------------------------------...

India IN: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Female data was reported at 19.800 NA in 2016. This records a decrease from the previous number of 20.000 NA for 2015. India IN: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Female data is updated yearly, averaging 21.200 NA from Dec 2000 (Median) to 2016, with 5 observations. The data reached an all-time high of 23.400 NA in 2000 and a record low of 19.800 NA in 2016. India IN: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Female data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s India – Table IN.World Bank.WDI: Health Statistics. Mortality from CVD, cancer, diabetes or CRD is the percent of 30-year-old-people who would die before their 70th birthday from any of cardiovascular disease, cancer, diabetes, or chronic respiratory disease, assuming that s/he would experience current mortality rates at every age and s/he would not die from any other cause of death (e.g., injuries or HIV/AIDS).; ; World Health Organization, Global Health Observatory Data Repository (http://apps.who.int/ghodata/).; Weighted average;

Do you know further standard populations?

If you know any further standard populations worth integrating in this dataset, please let me know in the discussion part. I would be happy to integrate further data to make this dataset more useful for everybody.

German "Federal Health Monitoring System" about 'standard populations':

"Standard populations are "artificial populations" with fictitious age structures, that are used in age standardization as uniform basis for the calculation of comparable measures for the respective reference population(s).

Use: Age standardizations based on a standard population are often used at cancer registries to compare morbidity or mortality rates. If there are different age structures in populations of different regions or in a population in one region over time, the comparability of their mortality or morbidity rates is only limited. For interregional or inter-temporal comparisons, therefore, an age standardization is necessary. For this purpose the age structure of a reference population, the so-called standard population, is assumed for the study population. The age specific mortality or morbidity rates of the study population are weighted according to the age structure of the standard population. Selection of a standard population:

Which standard population is used for comparison basically, does not matter. It is important, however, that

1. the demographic structure of the standard population is not too dissimilar to that of the reference population and
2. the comparable rates refer to the same standard."

Aim of this dataset

The aim of this dataset is to provide a variety of the most commonly used 'standard populations'.

Currently, two files with 22 standard populations are provided: - standard_populations_20_age_groups.csv - 20 age groups: '0', '01-04', '05-09', '10-14', '15-19', '20-24', '25-29', '30-34', '35-39', '40-44', '45-49', '50-54', '55-59', '60-64', '65-69', '70-74', '75-79', '80-84', '85-89', '90+' - 7 standard populations: 'Standard population Germany 2011', 'Standard population Germany 1987', 'Standard population of Europe 2013', 'Standard population Old Laender 1987', 'Standard population New Laender 1987', 'New standard population of Europe', 'World standard population' - source: German Federal Health Monitoring System

• standard_populations_19_age_groups.csv
  • 19 age groups: '0', '01-04', '05-09', '10-14', '15-19', '20-24', '25-29', '30-34', '35-39', '40-44', '45-49', '50-54', '55-59', '60-64', '65-69', '70-74', '75-79', '80-84', '85+'
  • 15 standard populations: '1940 U.S. Std Million', '1950 U.S. Std Million', '1960 U.S. Std Million', '1970 U.S. Std Million', '1980 U.S. Std Million', '1990 U.S. Std Million', '1991 Canadian Std Million', '1996 Canadian Std Million', '2000 U.S. Std Million', '2000 U.S. Std Population (Census P25-1130)', '2011 Canadian Standard Population', 'European (EU-27 plus EFTA 2011-2030) Std Million', 'European (Scandinavian 1960) Std Million', 'World (Segi 1960) Std Million', 'World (WHO 2000-2025) Std Million'
  • source: National Institutes of Health, National Cancer Institute, Surveillance, Epidemiology, and End Results Program

Terms of use

No restrictions are known to the author. Standard populations are published by different organisations for public usage.

Kenya KE: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data was reported at 13.400 % in 2016. This records an increase from the previous number of 13.300 % for 2015. Kenya KE: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data is updated yearly, averaging 13.400 % from Dec 2000 (Median) to 2016, with 5 observations. The data reached an all-time high of 17.300 % in 2000 and a record low of 13.300 % in 2015. Kenya KE: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s Kenya – Table KE.World Bank: Health Statistics. Mortality from CVD, cancer, diabetes or CRD is the percent of 30-year-old-people who would die before their 70th birthday from any of cardiovascular disease, cancer, diabetes, or chronic respiratory disease, assuming that s/he would experience current mortality rates at every age and s/he would not die from any other cause of death (e.g., injuries or HIV/AIDS).; ; World Health Organization, Global Health Observatory Data Repository (http://apps.who.int/ghodata/).; Weighted Average;

BackgroundWe aim to evaluate the global, regional, and national burden of Uterine Cancer (UC) from 1990 to 2019.MethodsWe gathered UC data across 204 countries and regions for the period 1990-2019, utilizing the Global Burden of Disease Database (GBD) 2019 public dataset. Joinpoint regression analysis was employed to pinpoint the year of the most significant changes in global trends. To project the UC trajectory from 2020 to 2044, we applied the Nordpred analysis, extrapolating based on the average trend observed in the data. Furthermore, the Bayesian Age-Period-Cohort (BAPC) model with integrated nested Laplace approximations was implemented to confirm the stability of the Nordpred analysis predictions.ResultsGlobally, the age-standardized rate (ASR) of incidence for UC has increased from 1990 to 2019 with an Average Annual Percentage Change (AAPC) of 0.50%. The ASR for death has declined within the same period (AAPC: -0.8%). An increase in the ASR of incidence was observed across all Socio-demographic Index (SDI) regions, particularly in High SDI regions (AAPC: 1.12%), while the ASR for death decreased in all but the Low SDI regions. Over the past 30 years, the highest incidence rate was observed in individuals aged 55-59 (AAPC: 0.76%). Among 204 countries and regions, there was an increase in the ASR of incidence in 165 countries and an increase in the ASR of deaths in 77 countries. Our projections suggest that both the incidence and death rates for UC are likely to continue their decline from 2020 to 2044.ConclusionsUC has significantly impacted global health negatively, with its influence stemming from a range of factors including geographical location, age-related and racial disparities, and SDI.

Nigeria NG: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Male data was reported at 20.900 NA in 2016. This records an increase from the previous number of 20.800 NA for 2015. Nigeria NG: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Male data is updated yearly, averaging 21.000 NA from Dec 2000 (Median) to 2016, with 5 observations. The data reached an all-time high of 22.600 NA in 2000 and a record low of 20.800 NA in 2015. Nigeria NG: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Male data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s Nigeria – Table NG.World Bank.WDI: Health Statistics. Mortality from CVD, cancer, diabetes or CRD is the percent of 30-year-old-people who would die before their 70th birthday from any of cardiovascular disease, cancer, diabetes, or chronic respiratory disease, assuming that s/he would experience current mortality rates at every age and s/he would not die from any other cause of death (e.g., injuries or HIV/AIDS).; ; World Health Organization, Global Health Observatory Data Repository (http://apps.who.int/ghodata/).; Weighted average;

Nigeria NG: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data was reported at 22.500 % in 2016. This stayed constant from the previous number of 22.500 % for 2015. Nigeria NG: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data is updated yearly, averaging 22.900 % from Dec 2000 (Median) to 2016, with 5 observations. The data reached an all-time high of 25.500 % in 2000 and a record low of 22.500 % in 2016. Nigeria NG: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s Nigeria – Table NG.World Bank: Health Statistics. Mortality from CVD, cancer, diabetes or CRD is the percent of 30-year-old-people who would die before their 70th birthday from any of cardiovascular disease, cancer, diabetes, or chronic respiratory disease, assuming that s/he would experience current mortality rates at every age and s/he would not die from any other cause of death (e.g., injuries or HIV/AIDS).; ; World Health Organization, Global Health Observatory Data Repository (http://apps.who.int/ghodata/).; Weighted Average;

This csv reports melanoma registration rates, per 100,000 population, by age. Age is grouped in 5 year segments (eg 0–4 years old, 5–9 years old). New Zealand and Australia have the world’s highest rates of melanoma, the most serious type of skin cancer. Melanoma is mainly caused by exposure to ultraviolet (UV) light, usually from the sun. New Zealand has naturally high UV levels, especially during summer.
The risk of developing melanoma is affected by factors such as skin colour and type, family history, and the amount of sun exposure. Melanoma can affect people at any age, but the chance of developing a melanoma increases with age. We report on age-standardised rates of melanoma to account for the increasing proportion of older people in our population. Our data on melanoma registrations come from the New Zealand Cancer Registry and the Ministry of Health's Mortality Collection. The passing of the Cancer Registry Act 1993 and Cancer Registry Regulations 1994 led to significant improvements in data quality and coverage (Ministry of Health, 2013). A sharp increase in registrations after 1993 is likely to have been related to these legislative and regulatory changes; for this reason we have only analysed data from 1996. 2014–15 data are provisional and subject to change. More information on this dataset and how it relates to our environmental reporting indicators and topics can be found in the attached data quality pdf.

Saudi Arabia SA: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data was reported at 16.400 % in 2016. This records a decrease from the previous number of 16.500 % for 2015. Saudi Arabia SA: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data is updated yearly, averaging 17.900 % from Dec 2000 (Median) to 2016, with 5 observations. The data reached an all-time high of 18.900 % in 2000 and a record low of 16.400 % in 2016. Saudi Arabia SA: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s Saudi Arabia – Table SA.World Bank: Health Statistics. Mortality from CVD, cancer, diabetes or CRD is the percent of 30-year-old-people who would die before their 70th birthday from any of cardiovascular disease, cancer, diabetes, or chronic respiratory disease, assuming that s/he would experience current mortality rates at every age and s/he would not die from any other cause of death (e.g., injuries or HIV/AIDS).; ; World Health Organization, Global Health Observatory Data Repository (http://apps.who.int/ghodata/).; Weighted Average;

[Notes: *Statistically significant difference (p = 0.005) between positive serology group (n = 47) and clinical criteria only group (n = 124) with respect to the patient characteristic (Chi-square test)].

Context

There's a story behind every dataset and here's your opportunity to share yours.

Content

What's inside is more than just rows and columns. Make it easy for others to get started by describing how you acquired the data and what time period it represents, too. Welcome to our regular closed dataset based weekend hackathon. In this weekend hackathon, we are challenging all the machinehackers to predict the melanoma tumor size based on various attributes. Melanomas present in many different shapes, sizes, and colors. That’s why it’s tricky to provide a comprehensive set of warning signs. Melanoma, also known as malignant melanoma, is a type of skin cancer that develops from the pigment-producing cells known as melanocytes. The primary cause of melanoma is ultraviolet light (UV) exposure in those with low levels of the skin pigment melanin. The UV light may be from the sun or other sources, such as tanning devices.

Melanoma is the most dangerous type of skin cancer. Globally, in 2012, it newly occurred in 232,000 people. In 2015, there were 3.1 million people with active disease, which resulted in 59,800 deaths. Australia and New Zealand have the highest rates of melanoma in the world. There are also high rates in Northern Europe and North America, while it is less common in Asia, Africa, and Latin America. In the United States melanoma occurs about 1.6 times more often in men than women.

Data Description:

Train.csv - 9146 rows x 9 columns
Test.csv - 36584 rows x 8 columns
Sample Submission - Acceptable submission format 

Attributes Description:

mass_npea: the mass of the area understudy for melanoma tumor
size_npear: the size of the area understudy for melanoma tumor
malign_ratio: ration of normal to malign surface understudy
damage_size: unrecoverable area of skin damaged by the tumor
exposed_area: total area exposed to the tumor
std_dev_malign: standard deviation of malign skin measurements
err_malign: error in malign skin measurements
malign_penalty: penalty applied due to measurement error in the lab
damage_ratio: the ratio of damage to total spread on the skin
tumor_size: size of melanoma_tumor

Acknowledgements

We wouldn't be here without the help of others. If you owe any attributions or thanks, include them here along with any citations of past research.

Inspiration

Your data will be in front of the world's largest data science community. What questions do you want to see answered?

Context

In the shadows of the Covid-19 pandemic, there is another global health crisis that has gone largely unnoticed. This is the Noncommunicable Disease (NCD) pandemic.

The WHO website describes NCDs as follows:

Noncommunicable diseases (NCDs), also known as chronic diseases, tend to be of long duration and are the result of a combination of genetic, physiological, environmental and behaviours factors.

The main types of NCDs are cardiovascular diseases (like heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructive pulmonary disease and asthma) and diabetes.

NCDs disproportionately affect people in low- and middle-income countries where more than three quarters of global NCD deaths – 32million – occur.

Key facts:

• Noncommunicable diseases (NCDs) kill 41 million people each year, equivalent to 71% of all deaths globally.
• Each year, 15 million people die from a NCD between the ages of 30 and 69 years; over 85% of these "premature" deaths occur in low- and middle-income > * countries.
• Cardiovascular diseases account for most NCD deaths, or 17.9 million people annually, followed by cancers (9.0 million), respiratory diseases (3.9million), and diabetes (1.6 million).
• These 4 groups of diseases account for over 80% of all premature NCD deaths.
• Tobacco use, physical inactivity, the harmful use of alcohol and unhealthy diets all increase the risk of dying from a NCD.
• Detection, screening and treatment of NCDs, as well as palliative care, are key components of the response to NCDs.

Content

This data repository consists of 3 CSV files: WHO-cause-of-death-by-NCD.csv is the main dataset, which provides the percentage of deaths caused by NCDs out of all causes of death, for each nation globally. Metadata_Country.csv and Metadata_Indicator.csv provide additional metadata which is helpful for interpreting the main CSV.

The data collected spans a period from 2000 to 2016. The main CSV has columns for every year from 1960 to 2019. It is advisable to drop all redundant columns where no data was collected.

Furthermore, it is advisable to merge Metadata_Country.csv with the main CSV as it provides valuable additional information, particularly on the economic situation of each nation.

Acknowledgements

This dataset has been extracted from The World Bank 'Cause of death, by non-communicable diseases (% of total)' Dataset, derived based on the data from WHO's Global Health Estimates. It is freely provided under a Creative Commons Attribution 4.0 International License (CC BY 4.0), with the additional terms as stated on the World Bank website: World Bank Terms of Use for Datasets.

Inspiration

I would be interested to see some good data wrangling (dropping redundant columns), as well as kernels interpreting additional information in 'SpecialNotes' column in Metadata_country.csv

It would also be great to see what different factors influence NCDs: most of all, the geopolitical factors. Would be great to see some choropleth visualisations to get an idea of which regions are most affected by NCDs.

Aim: We aimed to estimate the disease burden and risk factors attributable to ovarian cancer, and epidemiological trends at global, regional, and national levels.Methods: We described ovarian cancer data on incidence, mortality, and disability-adjusted life-years as well as age-standardized rates from 1990 to 2017 from the Global Health Data Exchange database. We also estimated the risk factors attributable to ovarian cancer deaths and disability-adjusted life-years. Measures were stratified by region, country, age, and socio-demographic index. The estimated annual percentage changes and age-standardized rates were calculated to evaluate temporal trends.Results: Globally, ovarian cancer incident, death cases, and disability-adjusted life-years increased by 88.01, 84.20, and 78.00%, respectively. However, all the corresponding age-standardized rates showed downward trends with an estimated annual percentage change of −0.10 (−0.03 to 0.16), −0.33 (−0.38 to −0.27), and −0.38 (−0.32 to 0.25), respectively. South and East Asia and Western Europe carried the heaviest disease burden. The highest incidence, deaths, and disability-adjusted life-years were mainly in people aged 50–69 years from 1990 to 2017. High fasting plasma glucose level was the greatest contributor in age-standardized disability-adjusted life-years rate globally as well as in all socio-demographic index quintiles and most Global Disease Burden regions. Other important factors were high body mass index and occupational exposure to asbestos.Conclusion: Our study provides valuable information on patterns and trends of disease burden and risk factors attributable to ovarian cancer across age, socio-demographic index, region, and country, which may help improve the rational allocation of health resources as well as inform health policies.

BackgroundEsophageal cancer remains one of the deadliest cancers globally, highlighting significant health challenges and socioeconomic disparities. This study aims to measure its global burden, assess disparities by sex, age, and region, and evaluate health inequalities, with projections to 2050. The goal is to provide evidence to guide resource allocation and reduce the disease burden.MethodsUsing data from the Global Burden of Disease (GBD) 2021 study, we analyzed trends in prevalence, incidence, mortality, and Disability-Adjusted Life Years (DALYs) across sexes, age groups, and 204 countries and territories. Age-standardized rates (ASR) were calculated to account for population age structures. Trends over time were assessed using the estimated annual percentage change (EAPC). Health inequalities were evaluated using the Slope Index of Inequality (SII) and Concentration Index (CI). Future burdens were projected using Bayesian Age-Period-Cohort (BAPC) models.ResultsFrom 1990 to 2021, esophageal cancer cases increased: prevalence from 551.62 to 1004.2 thousand, incidence from 354.73 to 576.53 thousand, mortality from 356.26 to 538.6 thousand, and DALYs from 9753.57 to 12999.26 thousand. However, age-standardized rates declined: prevalence from 13.34 to 11.47, incidence from 8.86 to 6.65, mortality from 9.02 to 6.25, and DALYs from 235.32 to 148.56 per 100,000 people. The burden rises sharply after age 40, with males and low-SDI regions experiencing higher burdens. Health inequalities widened, with the SII for prevalence increasing from 2.52 to 5.67, and for deaths from 1.45 to 2.94. West Africa, North Europe, and North America saw rising prevalence rates, while East Asia showed a declining trend. A decreasing trend is observed in most countries and regions worldwide, particularly in East Asia, with projections suggesting a continued decline in the future.ConclusionAlthough projections indicate a decreasing trend, health inequalities have intensified. Regions such as West Africa, North Europe, and North America are experiencing rising prevalence. To address these disparities, targeted interventions, enhanced healthcare access, and preventive measures in high-burden areas are essential to reduce the global burden and advance health equity.

BackgroundBrain and central nervous system (CNS) cancers remain a significant contributor to mortality worldwide. This study aims to provide the latest assessment of the prevalence, incidence, mortality, and disability-adjusted life years (DALY) rates of brain and CNS cancers from 1990 to 2021 at the global, regional, and national levels, stratified by sex, age, and the Sociodemographic Index (SDI).MethodsData from the Global Burden of Disease (GBD) database were used to analyze the age-standardized prevalence (ASPR), incidence (ASIR), mortality (ASDR), and DALY rates of brain and CNS cancers. Joinpoint regression was employed to calculate the annual percent change (APC), and a log-transformed linear regression model was used to estimate the average annual percent change (EAPC) for trend analysis. The data were stratified by sex, 20 age groups, 21 GBD regions, 204 countries/territories, and five SDI quintiles.ResultsIn 2021, there were an estimated 975,279.16 (95% UI, 857,199.67–1,096,203.50) global cases of brain and CNS cancers. The ASPR was 12.01 (95% UI, 10.54–13.52) per 100,000 population; the ASIR was 4.28 (95% UI, 3.71–4.88) per 100,000; the ASDR was 3.06 (95% UI, 2.62–3.50) per 100,000; and the age-standardized DALY rate was 49.58 (95% UI, 28.22–69.92) per 100,000. By SDI regions, the High SDI region showed the highest ASPR and ASIR, the High-Middle SDI region had the highest ASDR and age-standardized DALY rates, and the Low SDI region reported the lowest rates. Geographically, the High-income Asia Pacific region recorded the highest ASPR, Western Europe the highest ASIR, and Central Europe the highest ASDR and age-standardized DALY rates. Overall, in most regions globally, ASIR, ASDR, and age-standardized DALY rates among males increased with age and exceeded those of females. In high-SDI regions, the burden of brain and CNS cancers was predominantly in older adults, whereas in low-SDI regions, the burden among children was pronounced.ConclusionThe global burden of brain and CNS cancers is highest in High and High-Middle SDI regions, with a particularly severe burden in children in Low SDI regions. A comprehensive understanding of the epidemiology of brain and CNS cancers is crucial for strengthening disease prevention and control efforts worldwide.

The last row shows the variation between these crude rates and those shown in Fig 1.

Ivory Coast CI: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Male data was reported at 28.200 NA in 2016. This records a decrease from the previous number of 28.500 NA for 2015. Ivory Coast CI: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Male data is updated yearly, averaging 27.700 NA from Dec 2000 (Median) to 2016, with 5 observations. The data reached an all-time high of 28.500 NA in 2015 and a record low of 25.200 NA in 2000. Ivory Coast CI: Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70: Male data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s Ivory Coast – Table CI.World Bank.WDI: Health Statistics. Mortality from CVD, cancer, diabetes or CRD is the percent of 30-year-old-people who would die before their 70th birthday from any of cardiovascular disease, cancer, diabetes, or chronic respiratory disease, assuming that s/he would experience current mortality rates at every age and s/he would not die from any other cause of death (e.g., injuries or HIV/AIDS).; ; World Health Organization, Global Health Observatory Data Repository (http://apps.who.int/ghodata/).; Weighted average;

Malaysia Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data was reported at 17.200 % in 2016. This records a decrease from the previous number of 17.300 % for 2015. Malaysia Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data is updated yearly, averaging 18.200 % from Dec 2000 (Median) to 2016, with 5 observations. The data reached an all-time high of 20.300 % in 2000 and a record low of 17.200 % in 2016. Malaysia Mortality from CVD, Cancer, Diabetes or CRD between Exact Ages 30 and 70 data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s Malaysia – Table MY.World Bank.WDI: Health Statistics. Mortality from CVD, cancer, diabetes or CRD is the percent of 30-year-old-people who would die before their 70th birthday from any of cardiovascular disease, cancer, diabetes, or chronic respiratory disease, assuming that s/he would experience current mortality rates at every age and s/he would not die from any other cause of death (e.g., injuries or HIV/AIDS).; ; World Health Organization, Global Health Observatory Data Repository (http://apps.who.int/ghodata/).; Weighted average;