In 2023, the Americas reported the highest number of dengue cases worldwide. By December 11, the region had recorded over four million cases. Within the Americas, the countries most affected by dengue are located in the Central and Southern region.

it was estimated that in 2018 there were around 2.3 million people worldwide living with Sjögren’s syndrome. This number is predicted to increase to 2.5 million by the year 2027. Sjögren’s syndrome is an autoimmune disease that predominately impacts women.

Global Malaria Cases Reported by Country, 2023 Discover more data with ReportLinker!

Additional File 1: Supplementary tables S1-S10. Table S1. Number of incident cases and incidence rate of drug use disorders in the US in 1990 and 2021, and the temporal trends from 1990 to 2021. Table S2. Number of prevalent cases and prevalence rate of drug use disorders in the US in 1990 and 2021, and the temporal trends from 1990 to 2021. Table S3. Number of death cases and mortality rate of drug use disorders in the US in 1990 and 2021, and the temporal trends from 1990 to 2021. Table S4. Number of DALYs cases and DALYs rate of drug use disorders in the US in 1990 and 2021, and the temporal trends from 1990 to 2021. Table S5. Number of incident cases and incidence rate of global drug use disorders in 1990 and 2021, and the temporal trends from 1990 to 2021. Table S6. Number of prevalent cases and prevalence rate of global drug use disorders in 1990 and 2021, and the temporal trends from 1990 to 2021. Table S7. Number of death cases and mortality rate of global drug use disorders in 1990 and 2021, and the temporal trends from 1990 to 2021. Table S8. Number of DALYs cases and DALYs rate of global drug use disorders in 1990 and 2021, and the temporal trends from 1990 to 2021. Table S9. Prediction number of drug use disorders-related burden from 2022 to 2035 in the US. Table S10. Number and rate of drug use disorders burden by state, sex, and type in the US in 2021, and the temporal trends from 1990 to 2021.

Global Hospital Discharges for Infectious and Parasitic Diseases Cases by Country, 2023 Discover more data with ReportLinker!

BackgroundFlavivirus pose a continued threat to global health, yet their worldwide burden and trends remain poorly quantified. We aimed to evaluate the global, regional, and national incidence of three common flavivirus infections (Dengue, yellow fever, and Zika) from 2011 to 2021.MethodsData on the number and rate of incidence for the three common flavivirus infection in 204 countries and territories were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. The estimated annual percent change (EAPC) was calculated to quantify the temporal trend during 2011–2016, 2016–2019, and 2019–2021, respectively.ResultsIn 2021, an estimated 59,220,428 individuals were infected globally, comprising 58,964,185 cases of dengue, 86,509 cases of yellow fever, and 169,734 cases of Zika virus infection. The age-standardized incidence rate (ASIR) of the three common flavivirus infections increased by an annual average of 5.08% (95% CI 4.12 to 6.05) globally from 2011 to 2016, whereas decreased by an annual average of −8.37% (95% CI −12.46 to −4.08) per year between 2016 to 2019. The ASIR remained stable during 2019–2021, with an average change of 0.69% (95% CI −0.96 to 2.37) per year globally for the three common flavivirus infections. Regionally, the burden of the three common flavivirus infections was primarily concentrated in those regions with middle income, such as South Asia, Southeast Asia, and Tropical Latin America. Additionally, at the country level, there was an inverted “U” relationship between the SDI level and the ASI. Notably, an increase in the average age of infected cases has been observed worldwide, particularly in higher-income regions.ConclusionFlavivirus infections are an expanding public health concern worldwide, with considerable regional and demographic variation in the incidence. Policymakers and healthcare providers must stay vigilant regarding the impact of COVID-19 and other environmental factors on the risk of flavivirus infection and be prepared for potential future outbreaks.

BackgroundThis study aimed to examine the evolving trends in the global burden of low back pain (LBP) from 1990 to 2021 and predicted disease burden until 2035.Materials and methodsLBP-related data were obtained from the Global Health Data Exchange (GHDx) query tool. All estimates and their 95% uncertainty intervals (UIs) were generated using DisMod-MR 2.1, a Bayesian meta-regression tool in Global Burden of Disease, Injury, and Risk Factor Study (GBD) 2021. Data processing and visualization were conducted using The R Programming Language software version 4.3.2 and Joinpoint 4.7.ResultsIn 2021, approximately 628.8 million people worldwide were affected by LBP, with approximately 266.9 million new incident cases and age-standardized incidence rate (ASIR) of 3176.6 per 100,000. Compared with 1990, although the ASIR and age-standardized disability-adjusted life years rate (ASDALYsR) decreased, absolute numbers increased significantly. Projections for 2035 reveal a continued decline in ASIR and ASDALYsR for LBP. The LBP burden varied by the sociodemographic index quintile and GBD region, with the highest ASIR and ASDALYsR observed in Central Europe and the greatest decrease in East Asia. Globally, women bear a higher burden of LBP than men, with middle-aged populations experiencing the heaviest burden. Occupational ergonomic factors, high body mass index, and smoking remain the primary risk factors for LBP, with occupational ergonomic factors contributing the most to the overall burden.ConclusionDespite a projected decline in incidence, the global burden of LBP persists, exhibiting significant regional and gender disparities. To mitigate its future burden, precise and effective prevention and control strategies targeting high-risk factors are imperative.

In 2023, the share of cloud cyberattacks targeting organizations worldwide reached **** percent, up from the **** percent recorded in 2022. The increase had been consistent since 2021, when the share of cloud-based cyberattacks was around six percent.

Global Hospital Discharges for Crohn's Disease and Ulcerative Colitis Cases by Country, 2023 Discover more data with ReportLinker!

TD: Incidence of Tuberculosis: per 100,000 People data was reported at 140.000 Ratio in 2022. This stayed constant from the previous number of 140.000 Ratio for 2021. TD: Incidence of Tuberculosis: per 100,000 People data is updated yearly, averaging 147.000 Ratio from Dec 2000 (Median) to 2022, with 23 observations. The data reached an all-time high of 152.000 Ratio in 2003 and a record low of 140.000 Ratio in 2022. TD: Incidence of Tuberculosis: per 100,000 People data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s Chad – Table TD.World Bank.WDI: Social: Health Statistics. Incidence of tuberculosis is the estimated number of new and relapse tuberculosis cases arising in a given year, expressed as the rate per 100,000 population. All forms of TB are included, including cases in people living with HIV. Estimates for all years are recalculated as new information becomes available and techniques are refined, so they may differ from those published previously.;World Health Organization, Global Tuberculosis Report.;Weighted average;Aggregate data by groups are computed based on the groupings for the World Bank fiscal year in which the data was released by the World Health Organization. This is the Sustainable Development Goal indicator 3.3.2[https://unstats.un.org/sdgs/metadata/].

BackgroundNeonatal infections, especially neonatal sepsis, are one of the major causes of incidence and mortality in pediatrics. However, the global burden of neonatal sepsis and other neonatal infections (NSNIs) remains unclear.MethodsFrom the 2019 global disease burden study, we collected annual incident cases, deaths, age-standardized incidence rates (ASIRs), and age-standardized deaths rates (ASDRs) of NSNIs in the past 30 years. Analysis indicators included the percentage of relative changes in incident cases and deaths, and the estimated annual percentage changes (EAPCs) of ASIRs and ASDRs. Correlations were assessed between the EAPCs of ASIRs and ASDRs and social evaluation indicators, including sociodemographic index (SDI) and universal health coverage index (UHCI).ResultsGlobally, the number of incident cases of NSNIs grew by 12.79% per year, and the number of deaths dropped by 12.93% per year. During this period, global ASIR of NSNIs increased by 46% annually on average, while ASDR decreased by 53% annually on average. The ASIR and ASDR of female NSNIs were consistently lower than that of male NSNIs. The EAPC of female ASIR was 0.61, nearly twice that of male ASIR, and female ASIR was growing rapidly. The same declining trends of ASDR were noted in males and females. The ASIR of NSNIs in high-SDI regions grew by an average of 14% annually from 1990 to 2019. Except for high-SDI regions, the ASIRs of other 4 SDI regions maintained a rising trend at a high level, and were improved in the past 10 years. The ASDRs of all 5 SDI regions generally showed a downward trend. The region with the highest ASIR of NSNIs was Andean Latin America, and Western Sub-Saharan Africa had the highest mortality. We found a negative correlation between EAPCs of ASDRs and UHCI in 2019.ConclusionThe global health situation was still not optimal. The incidence of NSNIs remained high, and continues to rise. The mortality of NSNIs has decreased, especially in the countries/territories with high UHCI. Therefore, it is crucial to improve the overall awareness and management of NSNIs, and take interventions for NSNIs worldwide.

In 2019, the number of incident cases of Down syndrome worldwide was around ******. At that time, South Asia had the highest number of new Down Syndrome cases worldwide. This statistic shows the number of incidence cases of Down syndrome worldwide in 1990 and 2019, by region.

A curated database of legal cases where generative AI produced hallucinated citations submitted in court filings.

BackgroundIntracerebral hemorrhage (ICH) remains a leading contributor to mortality and long-term disability worldwide. This study aims to report global trends in the incidence, mortality and disability-adjusted life years (DALYs) of ICH among youths and young adults from 1990 to 2021.MethodsThis study analyzed ICH incidence, mortality, and DALYs in youth and young adults aged 15–39 years using data from the Global Burden of Disease (GBD) database. Rates for incidence, mortality, and DALYs were calculated per 100,000 population with 95% uncertainty intervals (UIs). Data from 204 countries and territories were stratified by age, sex, and location. Temporal trends were assessed through Joinpoint regression models to compute annual percent change (APC) and log-transformed linear regression models to estimate the average annual percentage change (EAPC).ResultsGlobally, the incidence of ICH among youths and young adults in 2021 was 246938.25 (95% UI, 192258.36–303133.32), with 85038.37 deaths (95% UI, 76818.49–93855.53), and 5385247.12 DALYs (95% UI, 4884623.97–5910984.71). From 1990 to 2021, the incidence decreased by −0.4% (95% UI, −6.14 to 5.54%), mortality by −4.62% (95% UI, −14.24 to 6.74%), and DALYs by −5.08% (95% UI, −13.98 to 5.38%). The incidence rate declined from 11.31 (95% UI, 8.56, 14.27) per 100,000 individuals in 1990 to 8.30 (95% UI, 6.46, 10.19) per 100,000 individuals in 2021, an overall decrease of −26.62% (95% UI, −30.85 to −22.24). Among the five Sociodemographic Index (SDI) regions, the highest EAPCs were observed in the high SDI regions for incidence (−1.63%; 95% CI, −1.74 to −1.52), mortality (−1.79%; 95% CI, −2.01 to −1.58), and DALYs (−1.67%; 95% UI, −1.84 to −1.50). At the national level, China had the highest number of ICH cases globally in 2021, with 49364.51 cases (95% UI, 37242.00–62918.59). The main risk factors for ICH-related mortality and DALYs globally are hypertension, air pollution, and tobacco use.ConclusionThe global incidence, mortality, and DALYs of ICH among youths and young adults are generally on a declining trend. The main risk factors are hypertension, air pollution, and tobacco use. A thorough understanding of the epidemiology of ICH in youths and young adults is crucial for developing timely and effective intervention measures.

Background and objectiveMultiple myeloma (MM) is the second most common haematologic malignancy. This study aimed to assess the global burden of multiple myeloma across 204 countries and territories from 1990 to 2021.MethodsThe data for this study were obtained from the Global Burden of Disease (GBD) 2021 dataset, which provides comprehensive information on the global and regional burden of 369 diseases, injuries, and 88 risk factors across 204 countries and territories from 1990 to 2021. We analyzed the incidence, mortality, disability-adjusted life years (DALYs), and disease-related risk factors of MM from 1990 to 2021. Age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALYs rate (ASDR) were calculated and analyzed. We also analyzed trends over time by gender and age, and assessed the impact of socio-demographic index (SDI) on disease burden. In addition, the global burden of MM from 2021 to 2035 was predicted by a Bayesian age-period-cohort (BAPC) model.ResultsIn 2021, there were 148,755 cases of MM globally. From 1990 to 2021, the global ASIR, ASMR, and ASDR increased (EAPC = 0.48, 0.09 and 0.06, respectively). In general, the ASIR, ASMR, and ASDR of MM and SDI levels are positive correlated, as regions with higher SDI levels normally have higher ASIR, ASMR, and ASDR. The incidence and mortality rates were higher in males than in females in all age groups, and increased with age before 90 years. We projected that the ASIR, ASMR, and ASDR of MM would obviously increase over the next dozen years through BAPC model.ConclusionThe findings in this study offer valuable insights into the global distribution and magnitude of the MM burden, which may be instructive for better making public health policy and reasonably allocating medical source.

MDS: COVID-19: Confirmed Cases: To Date: Northeast data was reported at 7,630,138.000 Person in 03 May 2025. This records an increase from the previous number of 7,629,902.000 Person for 02 May 2025. MDS: COVID-19: Confirmed Cases: To Date: Northeast data is updated daily, averaging 6,887,752.000 Person from Feb 2020 (Median) to 03 May 2025, with 1895 observations. The data reached an all-time high of 7,630,138.000 Person in 03 May 2025 and a record low of 0.000 Person in 05 Mar 2020. MDS: COVID-19: Confirmed Cases: To Date: Northeast data remains active status in CEIC and is reported by Ministry of Health. The data is categorized under High Frequency Database’s Disease Outbreaks – Table BR.HLA001: Disease Outbreaks: COVID-19: Confirmed Cases. Current day data is released daily between 6PM and 7PM Brazil Time. Weekend data are updated following Monday morning, Hong Kong Time.

MDS: COVID-19: Confirmed Cases: To Date: Central West data was reported at 4,610,386.000 Person in 03 May 2025. This records an increase from the previous number of 4,610,224.000 Person for 02 May 2025. MDS: COVID-19: Confirmed Cases: To Date: Central West data is updated daily, averaging 3,953,610.000 Person from Feb 2020 (Median) to 03 May 2025, with 1895 observations. The data reached an all-time high of 4,610,386.000 Person in 03 May 2025 and a record low of 0.000 Person in 06 Mar 2020. MDS: COVID-19: Confirmed Cases: To Date: Central West data remains active status in CEIC and is reported by Ministry of Health. The data is categorized under High Frequency Database’s Disease Outbreaks – Table BR.HLA001: Disease Outbreaks: COVID-19: Confirmed Cases. Current day data is released daily between 6PM and 7PM Brazil Time. Weekend data are updated following Monday morning, Hong Kong Time.

Regression analysis of Malaria incidence and other individual cancer mortality. (XLS 55Â kb)

MDS: COVID-19: Confirmed Cases: To Date: North: Roraima data was reported at 192,172.000 Person in 26 Apr 2025. This records an increase from the previous number of 192,161.000 Person for 25 Apr 2025. MDS: COVID-19: Confirmed Cases: To Date: North: Roraima data is updated daily, averaging 175,009.000 Person from Feb 2020 (Median) to 26 Apr 2025, with 1888 observations. The data reached an all-time high of 192,172.000 Person in 26 Apr 2025 and a record low of 0.000 Person in 21 Mar 2020. MDS: COVID-19: Confirmed Cases: To Date: North: Roraima data remains active status in CEIC and is reported by Ministry of Health. The data is categorized under High Frequency Database’s Disease Outbreaks – Table BR.HLA001: Disease Outbreaks: COVID-19: Confirmed Cases. Current day data is released daily between 6PM and 7PM Brazil Time. Weekend data are updated following Monday morning, Hong Kong Time.

ObjectivesHip dislocation is a critical clinical emergency that demands immediate intervention to prevent complications such as avascular necrosis, nerve damage, and long-term joint dysfunction. As population demographics evolve—with aging populations and increasing urbanization—and injury patterns shift due to factors such as road traffic accidents, sports-related injuries, and occupational hazards, the need to update our understanding of the epidemiology of hip dislocation becomes ever more pressing. These changes highlight the importance of identifying high-risk groups and tailoring preventive and therapeutic strategies accordingly. This study leverages comprehensive data from the Global Burden of Disease (GBD) 2021 to analyze the latest trends, disease burden, and population-specific patterns of hip dislocation. This analysis aims to produce evidence-based insights that inform clinical practice, guide public health policies, and promote efficient resource allocation. The findings will also help predict future trends, enabling proactive measures to mitigate the impact of hip dislocation on global health.MethodsData from the GBD 2021 was utilized to calculate the estimated annual percentage change in hip dislocation metrics. A comprehensive analysis of population patterns was conducted, focusing specifically on region, age and gender distributions. Key measures included crude and age-standardized incidence rates, crude and age-standardized Years Lived with Disability (YLDs) rates, and absolute case numbers and corresponding 95% uncertainty intervals (UIs). The estimated annual percentage change (EAPC) and corresponding 95% confidence intervals (CIs) were calculated, with positive EAPC values indicating an increasing trend and negative values indicating a decreasing trend. Socio-Demographic Index (SDI) was cross-analyzed with other study indicators to examine potential correlations. Bayesian Age-Period-Cohort models, implemented through the BAPC R package, were used to project changes in the disease burden of hip dislocation by 2030.ResultsFrom 1990 to 2021, the incidence rate and YLDs rate of hip dislocation decreased, while the number of cases and YLDs number increased. The disease burden is relatively high among the youth (15–24) and the older population (50+). In SDI-stratified analyses, incidence gaps narrowed across all quintiles, yet low-SDI regions still bore a comparatively higher residual disability burden by 2020. Males have consistently faced a heavier burden than females. High-energy trauma, particularly falls, warrants special attention in the older population. The total number of hip dislocation cases will increase, while the corresponding rate declines. Men will still bear a substantial disease burden of hip dislocation by 2030.ConclusionThe disease burden of hip dislocation remains a significant public health challenge. Data-driven analysis is pivotal for guiding clinical practice, shaping public health policies, and ensuring optimal allocation of healthcare resources. Strategic efforts are needed to address the persisting burden, particularly among high-risk demographic groups.