![]() (1, Atelectasis; 2, Cardiomegaly; 3, Effusion; 4, Infiltration; 5, Mass; 6, Nodule; 7, Pneumonia; 8, Pneumothorax; 9, Consolidation; 10, Edema; 11, Emphysema; 12, Fibrosis; 13, Pleural_Thickening; 14 Hernia) ### Background & Motivation: Chest X-ray exam is one of the most frequent and cost-effective medical imaging examination. However clinical diagnosis of chest X-ray can be challenging, and sometimes believed to be harder than diagnosis via chest CT imaging. Even some promising work have been reported in the past, and especially in recent deep learning work on Tuberculosis (TB) classification. To achieve clinically relevant computer-aided detection and diagnosis (CAD) in real world medical sites on all data settings of chest X-rays is still very difficult, if not impossible when only several thousands of images are employed for study. This is evident from [2] where the performance deep neural networks for thorax disease recognition is severely