Saved datasets
Last updated
Download format
Croissant
Croissant is a format for Machine Learning datasets
Learn more about this at mlcommons.org/croissant.
Usage rights
License from data provider
Please review the applicable license to make sure your contemplated use is permitted.
Topic
Provider
Free
Cost to access
Described as free to access or have a license that allows redistribution.
28 datasets found
  1. Data from: The Double Reduction of Cyclic Sulfonamides for the Synthesis of...

    • acs.figshare.com
    • figshare.com
    txt
    Updated Jun 6, 2023
  2. P

    Parallel Drive Axel Report

    • datainsightsmarket.com
    doc, pdf, ppt
    Updated Mar 17, 2025
  3. T

    Truck Differential Report

    • datainsightsmarket.com
    doc, pdf, ppt
    Updated Feb 9, 2025
  4. f

    Table_5_High-Resolution Linkage Map With Allele Dosage Allows the...

    • frontiersin.figshare.com
    xlsx
    Updated Jun 15, 2023
    + more versions
  5. P

    Parallel Drive Axel Report

    • datainsightsmarket.com
    doc, pdf, ppt
    Updated Mar 17, 2025
  6. j

    Data from: CO2 Electrochemical Reduction with Zn-Al Layered Double...

    • jstagedata.jst.go.jp
    • repository.uantwerpen.be
    jpeg
    Updated Sep 15, 2023
  7. m

    Automotive Tandem Axle Sales Market Size, Scope And Forecast Report

    • marketresearchintellect.com
    Updated Mar 20, 2024
  8. d

    Data from: Dual dimensionality reduction reveals independent encoding of...

    • datadryad.org
    • data.niaid.nih.gov
    • +1more
    zip
    Updated Mar 6, 2016
  9. d

    Data from: Meiosis at three loci in autotetraploids: Probabilities of gamete...

    • search.dataone.org
    • datadryad.org
    Updated Nov 29, 2023
  10. w

    Global Marine Reduction Gears Market Research Report: By Vessel Type...

    • wiseguyreports.com
    Updated Sep 24, 2024
  11. o

    Assessing the Prevalence of Socially Undesirable Opinions: The Use of the...

    • osf.io
    Updated Oct 15, 2021
  12. Data from: Intramolecular Reductive Double Cyclization of...

    • figshare.com
    txt
    Updated Jun 4, 2023
  13. Dataset from A Randomized, Double-blind Study of Safety and Reduction in...

    • data.niaid.nih.gov
    Updated Feb 22, 2025
    + more versions
  14. f

    Variance reduction results.

    • plos.figshare.com
    xls
    Updated Mar 14, 2024
    + more versions
  15. f

    The results of stability test.

    • plos.figshare.com
    xls
    Updated Dec 11, 2024
    + more versions
  16. Data from: Layered Halide Double Perovskites: Dimensional Reduction of...

    • acs.figshare.com
    • figshare.com
    txt
    Updated Jun 3, 2023
  17. Source Data File and SI Dataset 1 File for Manuscript "Probing the Effects...

    • figshare.com
    xlsx
    Updated May 30, 2023
  18. f

    Descriptive statistical analysis of variables.

    • plos.figshare.com
    xls
    Updated Jun 21, 2023
    + more versions
  19. f

    Data from: Complexities of the Reaction Mechanisms of CC Double Bond...

    • figshare.com
    • acs.figshare.com
    zip
    Updated May 31, 2023
  20. Data from: Computational Evaluation of Electrocatalytic Nitrogen Reduction...

    • figshare.com
    • acs.figshare.com
    txt
    Updated May 30, 2023
Share
FacebookFacebook
TwitterTwitter
Email
Click to copy link
Link copied
Close
Cite
Paul Evans (2023). The Double Reduction of Cyclic Sulfonamides for the Synthesis of (4S-Phenylpyrrolidin-2R-yl)methanol and 2S-Methyl-4S-phenylpyrrolidine [Dataset]. http://doi.org/10.1021/jo062189o.s002
Organization logo

Data from: The Double Reduction of Cyclic Sulfonamides for the Synthesis of (4S-Phenylpyrrolidin-2R-yl)methanol and 2S-Methyl-4S-phenylpyrrolidine

Related Article
Explore at:
13 scholarly articles cite this dataset (View in Google Scholar)
txtAvailable download formats
Dataset updated
Jun 6, 2023
Dataset provided by
ACS Publications
Authors
Paul Evans
License

Attribution-NonCommercial 4.0 (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/
License information was derived automatically

Description

The synthesis of (4S-phenylpyrrolidin-2R-yl)methanol and 2S-methyl-4S-phenylpyrrolidine has been achieved via the double reduction of their cyclic sulfonamide precursors which themselves were prepared following the stereoselective intramolecular Heck reaction of a chiral pool derived 2,5-dihydropyrrole. We have recently described a process whereby cyclic aryl sulfonamides, such as 2, are reductively ring-opened to furnish amino products in which the aryl group is incorporated in the final compound. (Evans, P.; McCabe, T.; Morgan, B. S.; Reau, S. Org. Lett. 2005, 7, 43.) The precursors for this reaction were assembled using an intramolecular Heck reaction followed by reduction of the alkene. Overall, this sequence represents an efficient means to construct molecules of this type in which the aryl sulfonyl moiety acts as both an N-protecting group and as an aryl donor. Use of Benkeser's stronger reducing conditions enables molecules such as 4 to be prepared in which both the sulfonamide functional group and the aromaticity of the aryl substituent have been destroyed.

Search
Clear search
Close search
Google apps
Main menu